Results 31 to 40 of about 72,001 (287)

Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions [PDF]

, 2005
Lipid levels in plasma strongly influence the risk for coronary heart disease. To localise and subsequently identify genes affecting lipid levels, we performed four genome-wide linkage scans followed by combined linkage/association analysis. Genome-scans
A Hamsten, AR Tall, Bastiaan T Heijmans, C Jurinke, CJ Etzel, DA Tregouet, Daniëlle Posthuma, DC Crawford, DC Rao, DL Rainwater, Dorret I Boomsma, E Lander, G Imperatore, G. Assmann, GP Vogler, GR Abecasis, GR Abecasis, GR Abecasis, H Coon, H Coon, H Knoblauch, HC van Houwelingen, Hein Putter, Henk Jan van der Wijk, J Blangero, J Lebrec, JC Cohen, JK Pritchard, JM Peacock, John B Whitfield, L Almasy, L Ose, L Peltonen, M Beekman, M Beekman, M Beekman, M Beekman, M Falchi, Marian Beekman, N Tahri-Daizadeh, Nancy L Pedersen, NE Morton, Nicholas G Martin, Nico Lakenberg, NJ Risch, P Eline Slagboom, P Libby, P Pajukanta, PC Sham, R DerSimonian, SM Fullerton, TI Pollin, Y Bossé   +52 more
core   +2 more sources

A comparison of different linkage statistics in small to moderate sized pedigrees with complex diseases

BMC Research Notes, 2012
Background In the last years GWA studies have successfully identified common SNPs associated with complex diseases. However, most of the variants found this way account for only a small portion of the trait variance.
Flaquer Antònia, Strauch Konstantin
doaj   +1 more source

Biallelic and Genome Wide Association Mapping of Germanium Tolerant Loci in Rice (Oryza sativa L.) [PDF]

, 2015
Funding: This project was partially funded by a Biotechnology and Biological Sciences Research Council (BBSRC) grant (BB/J003336/1) awarded to AHP. The work was also supported by a self-funded studentship (PT).
Douglas, Alex, Norton, Gareth J., Price, Adam H., Talukdar, Partha   +3 more
core   +3 more sources

Interval Mapping Using Nonparametric Accelerated Failure Time Cure Model [PDF]

Journal of Statistical Theory and Applications (JSTA), 2013
Many important problems in evolutionary biology begin with observations of phenotypic variation. Suppose time to an event-data are used to map quantitative trait loci (QTL) and underlying population is a mixture of susceptible and non-susceptible ...
Devrim Bilgili, Nader Ebrahimi
doaj   +1 more source

Genetic linkage mapping and QTL identification for salinity tolerance in Indian mustard (Brassica juncea L. Czern and Coss.) using SSR markers

Oil Crop Science, 2023
Soil salinity is one of the major environmental constraints that limits crop yield and nearly 7% of the total area worldwide is affected by salinity. Salinity-induced oxidative stress causes membrane damage during germination and seedling growth.
Rekha Patel, Sumit Jangra, Ram Avtar, Neelam R. Yadav, Ram C. Yadav   +4 more
doaj   +1 more source

Mapping QTLs for mineral accumulation and shoot dry biomass under different Zn nutritional conditions in Chinese cabbage ( Brassica rapa L. ssp. pekinensis ) [PDF]

, 2008
Chinese cabbage (Brassica rapa L. ssp. pekinensis) is one of the most important vegetables in China. Genetic dissection of leaf mineral accumulation and tolerance to Zn stress is important for the improvement of the nutritional quality of Chinese cabbage
Aarts, M.G.M., Koornneef, M., Li, X., Li, Y., Song, X., Sun, R., Wang, X.W., Wu, J., Yuan, Y.X., Zhang, X.W., Zhao, J.   +10 more
core   +2 more sources

A combined linkage and exome sequencing analysis for electrocardiogram parameters in the Erasmus Rucphen Family study

Frontiers in Genetics, 2016
Electrocardiogram (ECG) measurements play a key role in the diagnosis and prediction of cardiac arrhythmias and sudden cardiac death. ECG parameters, such as the PR, QRS, and QT intervals, are known to be heritable and genome-wide association studies ...
Claudia Tamar Silva, Claudia Tamar Silva, Claudia Tamar Silva, Irina Zorkoltseva, Najaf Amin, Ayse Demirkan, Ayse Demirkan, Elisabeth Maria van Leeuwen, Jan Kors, Marten van den Berg, Bruno Stricker, Bruno Stricker, Bruno Stricker, André Uitterlinden, Anatoly Kirichenko, Jacqueline C.M. Witteman, Rob Willemsen, Ben Oostra, Ben Oostra, Tatiana Axenovich, Cornelia Marja Van Duijn, Cornelia Marja Van Duijn, Aaron Isaacs, Aaron Isaacs   +23 more
doaj   +1 more source

Comment: Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies

, 2011
Comment on "Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies" [arXiv:1102.2774]Comment: Published in at http://dx.doi.org/10.1214/08-STS244A the Statistical Science (http://www.imstat.org/sts ...
Lo, Shaw-Hwa, Zheng, Tian
core   +1 more source

The Genetic Basis of Mutation Rate Variation in Yeast. [PDF]

, 2018
Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis ...
Bloom, Joshua S, Gou, Liangke, Kruglyak, Leonid   +2 more
core   +1 more source

Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Québec Family Study

Journal of Lipid Research, 2004
A genome-wide linkage study was performed to identify chromosomal regions harboring genes influencing lipid and lipoprotein levels. Linkage analyses were conducted for four quantitative lipoprotein/lipid traits, i.e., total cholesterol, triglyceride, HDL-
Y. Bossé, Y.C. Chagnon, J-P. Després, T. Rice, D.C. Rao, C. Bouchard, L. Pérusse, M-C. Vohl   +7 more
doaj   +1 more source