Results 51 to 60 of about 72,001 (287)

Prognostic values of SOFA score, qSOFA score, and LODS score for patients with sepsis

Annals of Palliative Medicine, 2020
Sepsis continues to carry a high rate of mortality, which makes effective and simple evaluation methods for predicting the prognosis of septic patients especially important. In this study, we retrospectively analyzed the relationships between three scoring systems including Sequential Organ Failure Assessment (SOFA) score, Quick SOFA (qSOFA) score, and
Yonglin, Li, Chunjiang, Yan, Ziyan, Gan, Xiaotu, Xi, Zhanpeng, Tan, Jun, Li, Guowei, Li   +6 more
openaire   +2 more sources

Medical Fabrics with Non‐Antibiotic, Supramolecular Antimicrobial Coatings: A Preventive Approach to Combat Biofilm Formation and Bacterial Dissemination

Advanced Healthcare Materials, EarlyView.
The study presents an antibiotic‐free strategy using medical fabrics coated with supramolecular assemblies of polyarginine and hyaluronic acid. These coatings showed strong antimicrobial and anti‐biofilm activity in vitro and in vivo, achieving major bacterial load reductions, including against MRSA.
Adjara Diarrassouba, Abdessalem Rekiki, Cécile Loubière, Sabine Kuchler‐Bopp, Lauriane Petit, Cynthia Calligaro, Derry Mercer, Aurore Gaudin, Naomi Canourgues, Emilie Adicéam, Benoit Beitz, Jeremy Welsch, Annabelle Vigué, Markus j. Kettel, Michael Karl, Chloé Guilbaud‐Chéreau, Philippe Lavalle, Nihal Engin Vrana, Skander Hathroubi   +18 more
wiley   +1 more source

Allele-Sharing Models: LOD Scores and Accurate Linkage Tests [PDF]

The American Journal of Human Genetics, 1997
Starting with a test statistic for linkage analysis based on allele sharing, we propose an associated one-parameter model. Under general missing-data patterns, this model allows exact calculation of likelihood ratios and LOD scores and has been implemented by a simple modification of existing software.
Kong, Augustine, Cox, Nancy J.
openaire   +2 more sources

Genome-Wide Association and Linkage Analysis of Quantitative Traits: Comparison pf Likelihood-Ratio Test and Conditional Score Statistic [PDF]

, 2009
Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype.
Dupuis, Josée, Hendricks, Audrey E, Zhu, Yanyan   +2 more
core   +1 more source

Electrically Readable Lateral Flow Assay Using Organic Transistors for Diagnostic Applications

Advanced Materials, EarlyView.
Electrolyte‐gated organic field‐effect transistors (EGOFETs) are integrated with lateral flow (LF) paper fluidics to create a reusable, portable, and low‐cost point‐of‐care (PoC) diagnostic test. The devices are validated for Human Immunoglobulin G detection, achieving high sensitivity (0.1 fm), selectivity, and reproducibility with rapid results in 20–
María Jesús Ortiz‐Aguayo, Carme Martínez‐Domingo, Diego Gutiérrez, Dean Kos, Marta Mas‐Torrent   +4 more
wiley   +1 more source

Identification of a novel locus for triglyceride on chromosome 1p31-32 in families with premature CAD and MI*

Journal of Lipid Research, 2008
An increased plasma triglyceride (TG) level is associated with coronary artery disease (CAD) and myocardial infarction (MI) and is a key characteristic of the metabolic syndrome.
Sara Bretschger Seidelmann, Lin Li, Gong-Qing Shen, Eric J. Topol, Qing Kenneth Wang   +4 more
doaj   +1 more source

A genetic locus for adolescent idiopathic scoliosis linked to chromosome 19p13.3 [PDF]

, 2002
Adolescent idiopathic scoliosis (ALS) is one of the most common orthopedic disorders, affecting up to 4% of schoolchildren worldwide. We studied seven unrelated multiplex families of southern Chinese descent with AIS, consisting of 25 affected members. A
Chan, TK, Chan, V, Fong, GCY, Lee, MK, Lu, DDS, Luk, KDK, Wong, MS, Yip, B   +7 more
core   +1 more source

Label‐Free SERS Fingerprinting of Neuroprotein Conformational Dynamics in Human Saliva

Advanced Materials, EarlyView.
Galvanic molecular entrapment (GME) is a label‐free method for detecting and quantifying neuroprotein conformational states. This technique enables direct surface binding and in situ hotspot generation around molecules, effectively overcoming challenges related to target localization and mismatched hotspot geometries.
Muhammad Shalahuddin Al Ja'farawy, Jun‐Yeong Yang, Chaewon Mun, Seunghun Lee, Chul Bum Cho, Yoo Hyun Um, Min‐Young Lee, Sung‐Gyu Park, Dong‐Ho Kim, Seung Ho Yang, Ho Sang Jung   +10 more
wiley   +1 more source

Handling linkage disequilibrium in qualitative trait linkage analysis using dense SNPs: a two-step strategy

BMC Genetics, 2009
Background In affected sibling pair linkage analysis, the presence of linkage disequilibrium (LD) has been shown to lead to overestimation of the number of alleles shared identity-by-descent (IBD) among sibling pairs when parents are ungenotyped.
Dupuis Josée, Cho Kelly
doaj   +1 more source

Comparison of empirical strategies to maximize GENEHUNTER lod scores [PDF]

Genetic Epidemiology, 1999
AbstractWe compare four strategies for finding the settings of genetic parameters that maximize the lod scores reported in GENEHUNTER 1.2. The four strategies are iterated complete factorial designs, iterated orthogonal Latin hypercubes, evolutionary operation, and numerical optimization.
C H, Chen, S J, Finch, N R, Mendell, D, Gordon   +3 more
openaire   +2 more sources