Results 31 to 40 of about 49,541 (265)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
EntropyA new methodology is introduced to solve classical Boolean problems as Hamiltonians, using the quantum approximate optimization algorithm (QAOA). This methodology is termed the “Boolean-Hamiltonians Transform for QAOA” (BHT-QAOA). Because a great deal of
Ali Al-Bayaty, Marek Perkowski
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
High-Performance Placement for VLSI Logic Synthesis
AlgorithmsLogic synthesis is a critical stage in the VLSI design flow. Logic synthesis methods without considering physical information would result in inferior solutions with timing violations and fail to meet high-performance design requirements.
Zhifeng Lin +3 more
doaj +1 more source
An Improved iMemComp OR Gate and its Applications in Logic Circuits
IEEE Journal of the Electron Devices Society, 2020 The iMemComp (Intelligent memristive computing) gates are a family of logic gates based on the RRAM (Resistive Random Access Memory) devices. It has potential advantage for the design of high-performance logic circuits, because the iMemComp NAND, AND ...
Feng Wei, Xiaole Cui, Xiaoxin Cui
doaj +1 more source
Smart minterm ordering and accumulation approach for insignificant function minimization
Ain Shams Engineering Journal, 2021 Previously finding prime implicants based on off-cubes was explored as an approach to minimize insignificant logic functions which include minterms both easy and difficult to cover.
Fatih Başçiftçi, Hakan Akar
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
An RTL-Based General Synthesis Methodology for Device-Independent Ternary Logic Circuits
IEEE AccessTernary logic circuits are considered a high-potential alternative that can continue the technological advance of binary logic. Current studies in ternary logic focus on two aspects: One focuses on designing specific ternary circuits (such as adders ...
Hanmok Park +3 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Planar Solid‐State Nanopores Toward Scalable Nanofluidic Integration Based on CMOS Technology
Advanced Engineering Materials, EarlyView.We present a scalable silicon‐based fabrication strategy for planar solid‐state nanopores to enable their integration with complex nanofluidic systems. Prototype devices demonstrate normal voltage‐current characteristics, good noise performance, and appreciable streaming currents. Our CMOS‐compatible fabrication process offers precise geometric control
Ngan Hoang Pham +7 more
wiley +1 more source