Results 31 to 40 of about 3,188,296 (245)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

High-Performance Placement for VLSI Logic Synthesis

open access: yesAlgorithms
Logic synthesis is a critical stage in the VLSI design flow. Logic synthesis methods without considering physical information would result in inferior solutions with timing violations and fail to meet high-performance design requirements.
Zhifeng Lin   +3 more
doaj   +1 more source

Optimization on the Complementation Procedure Towards Efficient Implementation of the Index Generation Function

open access: yesInternational Journal of Applied Mathematics and Computer Science, 2018
In the era of big data, solutions are desired that would be capable of efficient data reduction. This paper presents a summary of research on an algorithm for complementation of a Boolean function which is fundamental for logic synthesis and data mining.
Borowik Grzegorz
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

An RTL-Based General Synthesis Methodology for Device-Independent Ternary Logic Circuits

open access: yesIEEE Access
Ternary logic circuits are considered a high-potential alternative that can continue the technological advance of binary logic. Current studies in ternary logic focus on two aspects: One focuses on designing specific ternary circuits (such as adders ...
Hanmok Park   +3 more
doaj   +1 more source

Carbon Dots-Based Logic Gates

open access: yesNanomaterials, 2021
Carbon dots (CDs)-based logic gates are smart nanoprobes that can respond to various analytes such as metal cations, anions, amino acids, pesticides, antioxidants, etc.
Shweta Pawar   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

open access: yesFEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court   +3 more
wiley   +1 more source

Heuristic Synthesis of Reversible Logic – A Comparative Study

open access: yesAdvances in Electrical and Electronic Engineering, 2014
Reversible logic circuits have been historically motivated by theoretical research in low-power, and recently attracted interest as components of the quantum algorithm, optical computing and nanotechnology.
Chua Shin Cheng, Ashutosh Kumar Singh
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

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