Results 21 to 30 of about 6,876,355 (238)

The effect of adding inhaled corticosteroids to tiotropium and long-acting beta(2)-agonists for chronic obstructive pulmonary disease (Review) [PDF]

, 2011
BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropiumare commonly used, either on their own or in combination, for managing persistent symptoms of chronic obstructive pulmonary disease ...
Christopher J Cates, Karner, C, Cates, CJ, Charlotta Karner   +3 more
core   +1 more source

Combination therapy with indacaterol and glycopyrronium bromide in the management of COPD: an update on the evidence for efficacy and safety

Therapeutic Advances in Respiratory Disease, 2015
The international guidelines on chronic obstructive pulmonary disease (COPD) recommend inhaled bronchodilators for maintenance treatment of the disease. These drugs include β2-agonists and muscarinic antagonists, which are both available as short-acting ...
Erminia Ridolo, Marcello Montagni, Gian Galeazzo Riario-Sforza, Marco Baroni, Cristoforo Incorvaia   +4 more
doaj   +1 more source

The effect of glycopyrronium and indacaterol, as monotherapy and in combination, on the methacholine dose-response curve of mild asthmatics: a randomized three-way crossover study

Respiratory Research, 2017
Background Methacholine dose-response curves illustrate pharmacologic bronchoprotection against methacholine-induced airway hyperresponsiveness and can be used to quantitate changes in airway sensitivity (position), reactivity (slope), and maximal ...
Christianne M. Blais, Beth E. Davis, Donald W. Cockcroft   +2 more
doaj   +1 more source

Clinical Use of β2-adrenergic Receptor Agonists Based on Their Intrinsic Efficacy

Allergology International, 2005
Clinical choice of β2-adrenergic receptor agonists (β2-agonists) is based on the parameter of receptor selectivity, potency, and duration of action. The guidelines for asthma management describe nothing about intrinsic efficacy concerning the use of β2 ...
Hiroaki Kume
doaj   +1 more source

Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action [PDF]

, 2014
A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for potential as inhaled ultra-long acting bronchodilators. Determination of activities at the human β-adrenoreceptors demonstrated a series of highly potent and ...
Cadogan, Elaine, Jordan, Stephen, Connolly, Stephen, Ingall, Anthony, Stocks, Michael, Paine, Stuart, Christie, Jadeen, Fisher, Adrian, Mullen, Alex, Lawson, Mandy, Alcaraz, Lilian, Cook, Anthony, Dixon, John, Nicholls, David, Humphries, Alexander, Pairaudeau, Garry, Bailey, Andrew, Flaherty, Alice, School of Pharmacy, The University of Nottingham, AstraZeneca R&D Charnwood, Bonnert, Roger, Young, Alan   +21 more
core   +1 more source

Characteristics of medicine use for children with asthma in China: a nationwide population-based study

BMC Pediatrics, 2022
Objective To analyze the asthma medication use in Chinese children of different age groups, regions, and levels of cities in China, based on the 2015 Healthcare Insurance Data in China.
Ping Wu, Baoping Xu, Adong Shen, Huasong Zeng, Kunling Shen   +4 more
doaj   +1 more source

Once-daily single-inhaler versus twice-daily multiple-inhaler triple therapy in patients with COPD: lung function and health status results from two replicate randomized controlled trials

Respiratory Research, 2020
Background The comparative efficacy of inhaled corticosteroid/long-acting muscarinic antagonist/long-acting β2-agonist (ICS/LAMA/LABA) triple therapy administered via single or multiple inhalers in patients with chronic obstructive pulmonary disease ...
Gary T. Ferguson, Nicola Brown, Chris Compton, Thomas C. Corbridge, Kelly Dorais, Charles Fogarty, Catherine Harvey, Morrys C. Kaisermann, David A. Lipson, Neil Martin, Frank Sciurba, Marjorie Stiegler, Chang-Qing Zhu, David Bernstein   +13 more
doaj   +1 more source

Characteristics of users of inhaled long-acting β2-agonists in a Southern European population [PDF]

, 1999
We characterized the population of users of inhaled long-acting β2-agonists in the region of Friuli-Venezia Giulia, in Italy, and assessed changes in asthma treatment and control after initiating long-acting β2-agonists.All residents using formoterol or ...
Castellsague, J., Pérez-Gutthann, S., C. Cattaruzi, Garcia-Rodríguez, L.A., Troncon, M.G., L.A. Garcia-Rodríguez, M.G. Troncon, Agostinis, L., L. Agostinis, J. Castellsague, S. Pérez-Gutthann, Cattaruzi, C.   +11 more
core   +1 more source

A review of practical strategies for managing bronchial asthma in conventional medical systems

Indian Journal of Allergy Asthma and Immunology
Bronchial asthma is a chronic airway condition affecting about 10%–12% of adults and 15% of children worldwide. Treatment guidelines vary by asthma nature and severity.
Khadija Abdul Hafiz, Kaleem Ahmad, Mohd Aleemuddin Quamri   +2 more
doaj   +1 more source

Addressing unmet needs in the treatment of COPD [PDF]

European Respiratory Review, 2014
The burden of chronic obstructive pulmonary disease (COPD) is considerable, both socially and economically. Central to COPD management is the use of long-acting bronchodilators, which provide patients with optimal bronchodilation and improvements in ...
Francesco Patalano, Donald Banerji, Peter D’Andrea, Robert Fogel, Pablo Altman, Paul Colthorpe   +5 more
doaj   +1 more source