Results 11 to 20 of about 29,799 (243)

PECULIARITIES OF THERAPY WITH LONG ACTING β2-ADRENERGIC AGONISTFORMOTEROL FOR ASTHMA IN CHILDREN

Педиатрическая фармакология, 2006
Information on clinical use of long acting β2-adrenergic agonist formoterol in children with asthma is presented. Pharmacokinetics and pharmacodymanics are scrutinized in detail.
Yu.G. Levina, L.S. Namazova, V.V. Botvin'eva, N.I. Voznesenskaya, R.M. Torshkhoeva, K.E. Efendieva   +5 more
doaj   +4 more sources

The interaction of tiotropium with long lasting β2-agonists on lung cell function [PDF]

, 2013
The major question addressed in this thesis was to find the mechanism(s) by which muscarinic receptors interact with β2-adrenergic receptors in human airway fibroblasts.
Costa, Luigi
core   +1 more source

Risk of all-cause mortality or hospitalization for pneumonia associated with inhaled β2-agonists in patients with asthma, COPD or asthma-COPD overlap

Respiratory Research, 2022
β2-agonists provide necessary bronchodilatory action, are recommended by existing clinical practice guidelines and are widely prescribed for patients with these conditions.
Joseph Emil Amegadzie, John-Michael Gamble, Jamie Farrell, Zhiwei Gao   +3 more
doaj   +1 more source

Suboptimally controlled asthma in patients treated with inhaled ICS/LABA: prevalence, risk factors, and outcomes

npj Primary Care Respiratory Medicine, 2023
This observational claims-linked survey study assessed the prevalence of and risk factors for suboptimal asthma control and healthcare utilization in adults with asthma receiving fixed-dose combination (FDC) inhaled corticosteroid/long-acting β2-agonist (
Shiyuan Zhang, John White, Alyssa Goolsby Hunter, David Hinds, Andrew Fowler, Frances Gardiner, David Slade, Sharanya Murali, Wilhelmine Meeraus   +8 more
doaj   +1 more source

Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting β2-adrenoreceptor agonist (uLABA).

, 2015
The clinical pharmacokinetics of AZD3199, an ultra-long-acting β2-agonist, were investigated in healthy volunteers and patients with asthma or chronic obstructive pulmonary disease (COPD)
Jorup, Carin, Kuna, Piotr, Rosenborg, Johan, Bengtsson, Thomas, Bjermer, Leif   +4 more
core   +2 more sources

Combination therapy with indacaterol and glycopyrronium bromide in the management of COPD: an update on the evidence for efficacy and safety

Therapeutic Advances in Respiratory Disease, 2015
The international guidelines on chronic obstructive pulmonary disease (COPD) recommend inhaled bronchodilators for maintenance treatment of the disease. These drugs include β2-agonists and muscarinic antagonists, which are both available as short-acting ...
Erminia Ridolo, Marcello Montagni, Gian Galeazzo Riario-Sforza, Marco Baroni, Cristoforo Incorvaia   +4 more
doaj   +1 more source

The effect of glycopyrronium and indacaterol, as monotherapy and in combination, on the methacholine dose-response curve of mild asthmatics: a randomized three-way crossover study

Respiratory Research, 2017
Background Methacholine dose-response curves illustrate pharmacologic bronchoprotection against methacholine-induced airway hyperresponsiveness and can be used to quantitate changes in airway sensitivity (position), reactivity (slope), and maximal ...
Christianne M. Blais, Beth E. Davis, Donald W. Cockcroft   +2 more
doaj   +1 more source

Clinical Use of β2-adrenergic Receptor Agonists Based on Their Intrinsic Efficacy

Allergology International, 2005
Clinical choice of β2-adrenergic receptor agonists (β2-agonists) is based on the parameter of receptor selectivity, potency, and duration of action. The guidelines for asthma management describe nothing about intrinsic efficacy concerning the use of β2 ...
Hiroaki Kume
doaj   +1 more source

Characteristics of medicine use for children with asthma in China: a nationwide population-based study

BMC Pediatrics, 2022
Objective To analyze the asthma medication use in Chinese children of different age groups, regions, and levels of cities in China, based on the 2015 Healthcare Insurance Data in China.
Ping Wu, Baoping Xu, Adong Shen, Huasong Zeng, Kunling Shen   +4 more
doaj   +1 more source

Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action [PDF]

, 2014
A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for potential as inhaled ultra-long acting bronchodilators. Determination of activities at the human β-adrenoreceptors demonstrated a series of highly potent and ...
Cadogan, Elaine, Jordan, Stephen, Connolly, Stephen, Ingall, Anthony, Stocks, Michael, Paine, Stuart, Christie, Jadeen, Fisher, Adrian, Mullen, Alex, Lawson, Mandy, Alcaraz, Lilian, Cook, Anthony, Dixon, John, Nicholls, David, Humphries, Alexander, Pairaudeau, Garry, Bailey, Andrew, Flaherty, Alice, School of Pharmacy, The University of Nottingham, AstraZeneca R&D Charnwood, Bonnert, Roger, Young, Alan   +21 more
core   +1 more source