Results 31 to 40 of about 6,876,355 (238)

A pragmatic single-blind randomised controlled trial and economic evaluation of the use of leukotriene receptor antagonists in primary care at steps 2 and 3 of the national asthma guidelines (ELEVATE study)

Health Technology Assessment, 2011
Objectives: To evaluate, under real-life practice conditions in UK primary care, asthma control and cost-effectiveness of commencing therapy with leukotriene antagonists compared with inhaled corticosteroids (ICSs) as initial controller therapy and ...
D Price, S Musgrave, E Wilson, E Sims, L Shepstone, A Blyth, J Murdoch, M Mugford, E Juniper, J Ayres, S Wolfe, D Freeman, A Lipp, R Gilbert, I Harvey   +14 more
doaj   +1 more source

The impact of unsupervised and unconsented switch of inhalers in patients with controlled asthma – A targeted literature review

Annals of Thoracic Medicine, 2023
Inhaler combination formulations consisting of an inhaled corticosteroid (ICS) (fluticasone propionate) and a long-acting β2 agonist (salmeterol xinafoate) are indicated as maintenance treatments for patients with asthma and/or for selected patients with
Amr S Albanna, Mohammed Alhajji, Waleed Alsowayan, Mohamed Hany Soliman   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Chronic obstructive pulmonary disease patients electronic register analysis: the effectiveness of patient’s dynamic follow up and evaluation of treatment program [PDF]

Терапевтический архив, 2019
In the last few years new informatics methods were implemented in medicine and allowed to create big data including individual clinical markers of every patient.
V Ju Mishlanov, I V Shubin, K N Bekker, A V Katkova, E P Koshurnikova   +4 more
doaj   +1 more source

Quantifying the real life risk profile of inhaled corticosteroids in COPD by record linkage analysis [PDF]

, 2014
BACKGROUND: Inhaled corticosteroids (ICS), especially when prescribed in combination with long-acting β2 agonists have been shown to improve COPD outcomes.
Schembri, Stuart, Thomas M MacDonald, MacKenzie, Isla S.; id_orcid, Isla S MacKenzie, MacDonald, Thomas M., Rob W Flynn, Hapca, Adrian, Adrian Hapca, Flynn, Rob W., Stuart Schembri   +9 more
core   +2 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

A Pooled Analysis of Mortality in Patients with COPD Receiving Dual Bronchodilation with and without Additional Inhaled Corticosteroid

International Journal of COPD, 2022
Marc Miravitlles,1 Katia Verhamme,2 Peter MA Calverley,3 Michael Dreher,4 Valentina Bayer,5 Asparuh Gardev,6 Alberto de la Hoz,6 Jadwiga Wedzicha,7 David Price8,9 1Pneumology Department, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research ...
Miravitlles M, Verhamme K, Calverley PMA, Dreher M, Bayer V, Gardev A, de la Hoz A, Wedzicha J, Price D   +8 more
doaj  

Metabolomic changes related to airway inflammation, asthma pathogenesis and systemic activity following inhaled fluticasone furoate/vilanterol: a randomized controlled trial

Respiratory Research, 2022
Background Fluticasone furoate/vilanterol trifenatate (FF/VI) is an inhaled therapy for the treatment of asthma, with a prolonged duration of anti-inflammatory and bronchodilatory action.
Peter Daley-Yates, Brian Keppler, Amanda Baines, George Bardsley, James Fingleton   +4 more
doaj   +1 more source

Inhaled corticosteroids versus long-acting beta2-agonists for chronic obstructive pulmonary disease [PDF]

, 2011
Background Long-acting beta2-agonists and inhaled corticosteroids can be used as maintenance therapy by patients with moderate to severe chronic obstructive pulmonary disease. These interventions are often taken together in a combination inhaler. However,
David J Evans, Spencer, Sally, Spencer, S, Evans, David, Karner, C, Cates, CJ, Charlotta Karner, Christopher J Cates, Sally Spencer, Karner, Charlotta, Evans, DJ, Cates, Christopher, Spencer, Sally; id_orcid   +12 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source