Results 51 to 60 of about 6,876,355 (238)

Patient response and remission in respiratory disease: Special focus on severe asthma and chronic obstructive pulmonary disease

Journal of International Medical Research
Over the past decades, monoclonal antibodies have been playing a pivotal role in the treatment of chronic inflammatory airway diseases. Currently, ample data are available on the efficacy and safety of biologics in asthma from randomized controlled ...
Stefania Colantuono, Francesco Menzella, Pier-Valerio Mari, Francesco Macagno, Francesco Lombardi, Ilaria Baglivo, Cristiano Caruso   +6 more
doaj   +1 more source

Effect of Transdermal Tulobuterol Added to Inhaled Corticosteroids in Asthma Patients

Allergology International, 2005
Background: Tulobuterol tape is the first long-acting transdermal preparation of a p2-agonist designed to release tulobuterol in an optimal fashion over a 24-hour period.
Gen Tamura, Yasuyuki Sano, Kazuto Hirata, Shinichi Ishioka, Mitsuyoshi Nakashima, Terumasa Miyamoto   +5 more
doaj   +1 more source

Down-titration from high-dose combination therapy in asthma: Removal of long-acting β2-agonist [PDF]

, 2010
SummaryBackgroundAsthma guidelines recommend reducing inhaled corticosteroids (ICS) to the minimum effective dose, but the timing of long-acting β2-agonist (LABA) withdrawal is unclear.
Wark, Peter A.B., Sand, Ingrid B., Reddel, Helen K., Peters, Matthew J., Gibson, Peter G., Hoyos, Camilla M., Jenkins, Christine R.   +6 more
core   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Long-acting β2-agonists: how are they used in an optimal way? [PDF]

, 1997
Inhaled long-acting β2-agonists are frequently used for the treatment of asthma. When introduced to the market, the drug was accompanied by a debate among physicians and scientists raising warnings against the use of β2-agonists, leading to a risk of ...
Larsson, L., Bjermer, L.
core   +1 more source

Cortical Thickness and White Matter Surface Morphology in Tourette Syndrome: A Cohort Study

Annals of Neurology, EarlyView.
Objective To examine cortical thickness and white matter surface morphology in a large sample of individuals with Tourette syndrome (TS) and neurotypical controls across the lifespan, and to assess associations with symptom severity, comorbidities, and medication use.
Sahar Delavari, Adam C. Frank, Ravi Bansal, Flora M. Vaccarino, Robert A. King, Paul Lombroso, Lawrence Scahill, James F. Leckman, Bradley S. Peterson   +8 more
wiley   +1 more source

Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma [PDF]

, 2010
Background Formoterol is a long-acting beta(2)-agonist but because it has a fast onset of action it can also be used as a relief medication. Objectives To asses the efficacy and safety of formoterol as reliever therapy in comparison to short-acting ...
Christopher J Cates, Emma J Welsh, Welsh, EJ, Cates, CJ   +3 more
core   +1 more source

Long acting β2-agonist and corticosteroid restore airway glandular cell function altered by bacterial supernatant

Respiratory Research, 2010
Background Staphylococcus aureus releases virulence factors (VF) that may impair the innate protective functions of airway cells. The aim of this study was to determine whether a long-acting β2 adrenergic receptor agonist (salmeterol hydroxynaphthoate ...
Nawrocki-Raby Béatrice, Toumi Férial, Delavoie Franck, Zahm Jean-Marie, Kileztky Claire, Michel Jean, Balossier Gérard, Johnson Malcolm, Coraux Christelle, Birembaut Philippe   +9 more
doaj   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source