Results 51 to 60 of about 29,799 (243)

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Clinical Outcomes and Patient Experiences With Celiprolol Therapy in Vascular Ehlers–Danlos Syndrome: The First Non‐European Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Vascular Ehlers–Danlos syndrome (vEDS) is a hereditary connective tissue disorder caused by heterozygous pathogenic variants in COL3A1. European studies have shown that celiprolol may reduce the risk of life‐threatening vascular events, but outcomes in non‐European populations and the therapy's psychological impact remain unclear. We conducted
Megumi Furuhata‐Yoshimura, Tomomi Yamaguchi, Tomoki Kosho   +2 more
wiley   +1 more source

Long acting β2-agonist and corticosteroid restore airway glandular cell function altered by bacterial supernatant

Respiratory Research, 2010
Background Staphylococcus aureus releases virulence factors (VF) that may impair the innate protective functions of airway cells. The aim of this study was to determine whether a long-acting β2 adrenergic receptor agonist (salmeterol hydroxynaphthoate ...
Nawrocki-Raby Béatrice, Toumi Férial, Delavoie Franck, Zahm Jean-Marie, Kileztky Claire, Michel Jean, Balossier Gérard, Johnson Malcolm, Coraux Christelle, Birembaut Philippe   +9 more
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study

Pulmonology
Introduction Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence.
B. Sousa-Pinto, R. Louis, J.M. Anto, R. Amaral, A. Sá-Sousa, W. Czarlewski, L. Brussino, G.W. Canonica, C. Chaves Loureiro, A.A. Cruz, B. Gemicioglu, T. Haahtela, M. Kupczyk, V. Kvedariene, D.E. Larenas-Linnemann, Y. Okamoto, M. Ollert, O. Pfaar, N. Pham-Thi, F. Puggioni, F.S. Regateiro, J. Romantowski, J. Sastre, N. Scichilone, L. Taborda-Barata, M.T. Ventura, I. Agache, A. Bedbrook, S. Becker, K.C. Bergmann, S. Bosnic-Anticevich, M. Bonini, L.-P. Boulet, G. Brusselle, R. Buhl, L. Cecchi, D. Charpin, F. de Blay, S. Del Giacco, J.C. Ivancevich, M. Jutel, L. Klimek, H. Kraxner, P. Kuna, D. Laune, M. Makela, M. Morais-Almeida, R. Nadif, M. Niedoszytko, N.G. Papadopoulos, A. Papi, V. Patella, B. Pétré, D. Rivero Yeverino, C. Robalo Cordeiro, N. Roche, P.W. Rouadi, B. Samolinski, M. Savouré, M.H. Shamji, A. Sheikh, C. Suppli Ulrik, O.S. Usmani, A. Valiulis, A. Yorgancioglu, T. Zuberbier, J.A. Fonseca, E.M. Costa, J. Bousquet   +68 more
doaj   +1 more source

Effect of Bronchodilator and Steroid Use on Heart Disease and Stroke Risks in a Bronchiectasis–Chronic Obstructive Pulmonary Disease Overlap Cohort: A Propensity Score Matching Study

Frontiers in Pharmacology, 2019
Background: To determine the effects of bronchodilator, steroid, and anti-arrhythmia drug use on the risk of heart disease/stroke (HDS) in patients with bronchiectasis–chronic obstructive pulmonary disease overlap syndrome (BCOS).Methods: We ...
Jun-Jun Yeh, Jun-Jun Yeh, Jun-Jun Yeh, Yu-Cih Yang, Yu-Cih Yang, Chung Y. Hsu, Chia-Hung Kao, Chia-Hung Kao, Chia-Hung Kao, Chia-Hung Kao   +9 more
doaj   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source