Results 71 to 80 of about 11,495,017 (246)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The oncogenic potential of growth hormone.

, 2006
A growing body of recent literature indicates that in addition to an essential role in growth and development, growth hormone may also play a more sinister role in oncogenic transformation and neoplastic progression.
Starling Emerald, B, Mertani, HC, Lobie, Peter E, Perry, Jo K, Mertani, Hichem, Perry, Johanna, Emerald, B Starling, Lobie, Peter   +7 more
core   +1 more source

The effect of adding inhaled corticosteroids to tiotropium and long-acting beta(2)-agonists for chronic obstructive pulmonary disease (Review) [PDF]

, 2011
BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropiumare commonly used, either on their own or in combination, for managing persistent symptoms of chronic obstructive pulmonary disease ...
Christopher J Cates, Karner, C, Cates, CJ, Charlotta Karner   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Perspectives on long-acting growth hormone therapy in children and adults

, 2019
Growth hormone therapy with daily injections of recombinant human growth hormone has been available since 1985, and is shown to be safe and effective treatment for short stature in children and for adult growth hormone deficiency. In an effort to produce
Andrew R. Hoffman (8303916), Rayhan A. Lal (8303913)   +1 more
core   +1 more source

Investigating the role of growth hormone receptor in oesophageal squamous-cell carcinoma. [PDF]

, 2013
Includes abstract.Includes bibliographical references.Squamous-cell carcinoma of the oesophagus is a formidable disease which poses a significant health risk in developing countries where incidence is high and survival is low.
Boris Krivochiev, Krivochiev, Boris
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Decrease in adiponectin levels correlates to growth response in growth hormone-treated children

, 2009
BACKGROUND/AIMS: Adiponectin is secreted by adipose tissue and circulates in human plasma at high levels. Decreased adiponectin levels are associated with insulin resistance and obesity.
Carlsson, LMS, Swedish, Study Group for Growth Hormone Treatment, Andersson, B, Albertsson-Wikland, K, Carlsson, B, Bjarnason, R   +5 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Harmonization of growth hormone measurements with different immunoassays by data adjustment [PDF]

, 2011
Background: The aim of our study was to evaluate the between-assay variability of commercially available immunoassays for the measurement of human growth hormone (hGH).
Bidlingmaier, Martin, Oliver Blankenstein, Jürgen Kratzsch, Körner, Antje, Wieland Kiess, Anne Müller, Markus Scholz, Antje Körner, Thiery, Joachim, Martin Bidlingmaier, Müller, Anne, Scholz, Markus, Blankenstein, Oliver, Annegret Heider, Roland Pfäffle, Joachim Thiery, Heider, Annegret, Kratzsch, Jürgen, Gerhard Binder, Pfäffle, Roland, Binder, Gerhard, Kiess, Wieland   +21 more
core   +1 more source