Results 81 to 90 of about 11,495,017 (246)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Diagnosis, Genetics, and Therapy of Short Stature in Children : A Growth Hormone Research Society International Perspective [PDF]

, 2019
The Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to evaluate the diagnosis and therapy of short stature in children. Forty-six international experts participated at the invitation of GRS including clinicians, basic scientists ...
Bidlingmaier, Martin, Jorge, Alexander A.L., Boguszewski, Margaret C.S., Gong, Chunxiu, Kamenicky, Peter, Cohen, Laurie E., Backeljauw, Philippe F., Hasegawa, Yukihiro, Misra, Madhusmita, Kriström, Berit, Khadilkar, Vaman, Saenger, Paul, Woelfle, Joachim, Luo, Xiaoping, Radovick, Sally, Hoffman, Andrew R., Collett-Solberg, Paulo F., Rosenfeld, Ron G., Biller, Beverly M. K., Hofman, Paul L., Cheung, Pik To, Netchine, Irene, Rogol, Alan D., Kriström, Berit,, Choong, Catherine Seut Yhoke, Lopes, Maria de Lurdes A., Wit, Jan M., Biller, Beverly M.K., Cohen, Pinchas, Kopchick, John J., Horikawa, Reiko, Miller, Bradley S., Deal, Cheri L., Ambler, Geoffrey, Boguszewski, Margaret C. S., Juul, Anders, Ranke, Michael B., Dauber, Andrew, Jorge, Alexander A. L.   +38 more
core   +1 more source

FDA Has Approved First Long-Acting Growth Hormone Preparation for Children

Педиатрическая фармакология, 2021
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article Editorial
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Inhaled corticosteroids versus long-acting beta2-agonists for chronic obstructive pulmonary disease [PDF]

, 2011
Background Long-acting beta2-agonists and inhaled corticosteroids can be used as maintenance therapy by patients with moderate to severe chronic obstructive pulmonary disease. These interventions are often taken together in a combination inhaler. However,
David J Evans, Spencer, Sally, Spencer, S, Evans, David, Karner, C, Cates, CJ, Charlotta Karner, Christopher J Cates, Sally Spencer, Karner, Charlotta, Evans, DJ, Cates, Christopher, Spencer, Sally; id_orcid   +12 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Long-acting beta2-agonists for chronic obstructive pulmonary disease. [PDF]

, 2013
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a respiratory disease that causes progressive symptoms of breathlessness, cough and mucus build-up.
Walters, JA, Chris Mavergames, Kew, KM, Mavergames, C, Kayleigh M Kew, Julia AE Walters   +5 more
core   +1 more source

Acromegaly with No Evidence of Pituitary Adenoma or Ectopic Source

Endocrinology Research and Practice, 2017
Acromegaly is caused by the uncontrolled hypersecretion of growth hormone (GH) and secondary increases of insulin-like growth factor–1. More than 95% of patients with acromegaly have a growth hormone-secreting pituitary adenoma.
Işılay KALAN SARI, Hüseyin DEMİRCİ, Şenay ARIKAN DURMAZ   +2 more
doaj   +1 more source