Results 61 to 70 of about 12,197,984 (249)

Efficacy in Japanese adults with growth hormone deficiency receiving weekly somapacitan or daily growth hormone: results from phase 3 REAL 1 trial

Frontiers in Endocrinology
IntroductionSomapacitan is a long-acting growth hormone (GH) derivative approved for once-weekly treatment of adult GH deficiency (AGHD). This study aimed to evaluate the efficacy and safety of somapacitan and daily GH in Japanese individuals with AGHD ...
Fumio Otsuka, Michael Højby Rasmussen, Takaaki Endo, Claus Sværke, Shigeyuki Tahara, Gudmundur Johannsson   +5 more
doaj   +1 more source

Physician experience with once-weekly somatrogon versus once-daily rhGH regimen in pediatric patients with growth hormone deficiency: a cross-sectional survey of physicians from the global phase 3 study

Frontiers in Endocrinology, 2023
IntroductionThe standard of care for pediatric growth hormone deficiency (pGHD) is once-daily recombinant human growth hormone (rhGH). Somatrogon, a long-acting rhGH, requires less frequent, once-weekly, dosing.
Roy Gomez, Roger Lamoureux, Diane M. Turner-Bowker, Jane Loftus, Mohamad Maghnie, Mohamad Maghnie, Bradley S. Miller, Michel Polak, Andrew Yaworsky   +8 more
doaj   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Management of growth hormone deficiency in adults

, 2007
Growth hormone (GH) deficiency in adults is a recognised clinical entity. There is still, however, an ongoing debate of the clinical need and the importance of replacing GH in adults with severe GH deficiency.
Nilsson, Anna G,, Johannsson, Gudmundur,, Svensson, Johan,   +2 more
core   +1 more source

Diagnosis, Genetics, and Therapy of Short Stature in Children : A Growth Hormone Research Society International Perspective [PDF]

, 2019
The Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to evaluate the diagnosis and therapy of short stature in children. Forty-six international experts participated at the invitation of GRS including clinicians, basic scientists ...
Bidlingmaier, Martin, Jorge, Alexander A.L., Boguszewski, Margaret C.S., Gong, Chunxiu, Kamenicky, Peter, Cohen, Laurie E., Backeljauw, Philippe F., Hasegawa, Yukihiro, Misra, Madhusmita, Kriström, Berit, Khadilkar, Vaman, Saenger, Paul, Woelfle, Joachim, Luo, Xiaoping, Radovick, Sally, Hoffman, Andrew R., Collett-Solberg, Paulo F., Rosenfeld, Ron G., Biller, Beverly M. K., Hofman, Paul L., Cheung, Pik To, Netchine, Irene, Rogol, Alan D., Kriström, Berit,, Choong, Catherine Seut Yhoke, Lopes, Maria de Lurdes A., Wit, Jan M., Biller, Beverly M.K., Cohen, Pinchas, Kopchick, John J., Horikawa, Reiko, Miller, Bradley S., Deal, Cheri L., Ambler, Geoffrey, Boguszewski, Margaret C. S., Juul, Anders, Ranke, Michael B., Dauber, Andrew, Jorge, Alexander A. L., Boguszewski, Margaret, C S, Collett-Solberg, Paulo, F, Biller, BMK, Horikawa, R, Wit, JM, Deal, Cheri, L, Juul, A, Wit, Jan, M, Cohen, Laurie, E, Radovick, S, Hasegawa, Y, Misra, M, Hoffman, AR, Biller, Beverly, M K, Bidlingmaier, M, Rosenfeld, Ron, G, Choong, CSY, Collett-Solberg, PF, Backeljauw, Philippe, F, Rogol, AD, Woelfle, J, Lopes, ML, Ambler, G, Lopes, Maria, de Lurdes A, Backeljauw, PF, Ranke, MB, Kopchick, JJ, Cohen, P, Miller, BS, Saenger, P, Choong, Catherine, Seut Yhoke, Deal, CL, Kamenický, P, Dauber, A, Cheung, Pik, To, Khadilkar, V, Luo, X, Cheung, PT, Kriström, B, Jorge, AAL, Gong, C, Hofman, PL, Ranke, Michael, B, Hofman, Paul, L, Hoffman, Andrew, R, Rosenfeld, RG, Boguszewski, MCS, Netchine, Kopchick, John, J, Cohen, LE   +88 more
core   +1 more source

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source

Efficacy and safety of once-weekly somatrogon following up to 4 years of treatment in Japanese children with growth hormone deficiency: results from an open-label extension of a phase 3 study

Endocrine Journal
Somatrogon is a long-acting recombinant human growth hormone approved in several countries, including Japan, for the treatment of children with growth hormone deficiency (GHD).
Reiko Horikawa, Toshiaki Tanaka, Yukihiro Hasegawa, Tohru Yorifuji, David Ng, Ron G. Rosenfeld, Yuko Hoshino, Akifumi Okayama, Nozomi Ebata, Masayoshi Hosoi, Shinichi Nakamuta, Roy Gomez, Aleksandra Pastrak, Orlando Castellanos   +13 more
doaj   +1 more source

Plain language summary for "Weekly Somapacitan in GH Deficiency: 4-Year Efficacy, Safety and Treatment/Disease Burden Results from REAL 3"

, 2023
Plain language summary for "Childhood growth hormone deficiency, growth hormone treatment, daily growth hormone, somapacitan, long-acting growth hormone"
Lars Sävendahl (9986312), Reiko Horikawa (393659), Meryl Brod (11257694), Michael Højby Rasmussen (14699299), Tadej Battelino (4256770), Paul Saenger (14716153), Sebastian Röhrich (370448)   +6 more
core   +1 more source

Identifying Patterns of Hospitalizations Among Childhood Cancer Survivors: A Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood cancer survivors (CCSs) experience more hospitalizations than the general population. We aimed to identify distinct hospitalization patterns among Queensland CCSs and the associated characteristics. Methods Cases (aged ≤14 years) diagnosed between 1995 and 2019 while residents of Queensland were identified through the ...
Hai Pham, Teyl Engstrom, Peter Baade, Natalie Bradford, Sarah Pont, Louise Marquart‐Wilson, Natasha Nassar, Jason D. Pole   +7 more
wiley   +1 more source

Long-Acting Growth Hormone for Replacement Therapy [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2011
GH replacement therapy has shown important beneficial effects on body composition, bone metabolism, lipid metabolism, and quality of life in adults with GH deficiency with a good safety profile (1, 2). Current management is based on daily sc injections before bedtime that are often experienced as cumbersome by the patient and may therefore affect ...
openaire   +1 more source