Results 41 to 50 of about 11,495,017 (246)

Developments in the Management of Growth Hormone Deficiency: Clinical Utility of Somapacitan

Drug Design, Development and Therapy
Bradley S Miller,1 Jo Blair,2 Reiko Horikawa,3 Agnès Linglart,4– 7 Kevin CJ Yuen8 1Division of Pediatric Endocrinology, University of Minnesota Medical School, MHealth Fairview Masonic Children’s Hospital, Minneapolis, MN, USA; 2Department of Paediatric ...
Miller BS, Blair J, Horikawa R, Linglart A, Yuen KC   +4 more
doaj   +1 more source

Developing long‐acting growth hormone formulations [PDF]

Clinical Endocrinology, 2013
SummaryDaily recombinant growth hormone (GH) restores normal growth and body composition in GH‐deficient children and adults; however, daily injections are inconvenient and can be distressing for some children. On top of this compliance is a problem in up to 75% of children.
Pippa, Cawley, Ian, Wilkinson, Richard J, Ross   +2 more
openaire   +2 more sources

Effect of long-acting growth hormone treatment on endogenous growth hormone secretion in prepubertal patients with idiopathic short stature: A preliminary study

, 2022
Long-acting growth hormone (LAGH) is emerging to be a new preparation for treatment of short stature. We aimed to determine whether 12-month treatment with LAGH in patients with idiopathic short stature has an effect on the nocturnal endogenous growth ...
김호성, 서정환, 최한샘, 권아름, 송경철, 채현욱   +5 more
core   +1 more source

The rationale and design of TransCon Growth Hormone for the treatment of growth hormone deficiency

Endocrine Connections, 2017
The fundamental challenge of developing a long-acting growth hormone (LAGH) is to create a more convenient growth hormone (GH) dosing profile while retaining the excellent safety, efficacy and tolerability of daily GH.
Kennett Sprogøe, Eva Mortensen, David B Karpf, Jonathan A Leff   +3 more
doaj   +1 more source

Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation [PDF]

, 2010
Study found that treatment with recombinant human growth hormone gave significantly greater benefits in stature for children with growth hormone deficiency (GHD), Turner syndrome, Prader–Willi syndrome, chronic renal insufficency, short stature homeobox ...
Bird, A., Baxter, L, Gospodarevskaya, E., K Welch, Cooper, Keith, L Baxter, Frampton, G. K., A Bird, Frampton, GK, Gospodarevskaya, Elena, Gospodarevskaya, E, Welch, K, Bryant, J, Takeda, A, Frampton, G.K., Cooper, K., GK Frampton, Takeda, Andrea, Bird, A, Bryant, J., J Bryant, K Cooper, Welch, Karen, Welch, K., Baxter, L., Takeda, A., Bryant, Jackie, A Takeda, E Gospodarevskaya, Cooper, K   +29 more
core   +1 more source

Human Growth and Growth Hormone: From Antiquity to the Recominant Age to the Future

Frontiers in Endocrinology, 2021
Since antiquity Man has been fascinated by the variations in human (and animal) growth. Stories and art abound about giants and little people. Modern genetics have solved some of etiologies at both extremes of growth.
Evan Graber, Edward O. Reiter, Alan D. Rogol   +2 more
doaj   +1 more source

Long-acting Growth Hormones Produced by Conjugation with Polyethylene Glycol [PDF]

Journal of Biological Chemistry, 1996
Derivatives of human growth hormone (hGH) of increasing size were produced by reaction with the N-hydroxysuccinimide ester of polyethylene glycol-5000 (PEG5000), a 5-kDa reagent that selectively conjugates to primary amines. By adjusting the reaction conditions and purification procedure, it was possible to isolate hGH derivatives containing up to ...
R, Clark, K, Olson, G, Fuh, M, Marian, D, Mortensen, G, Teshima, S, Chang, H, Chu, V, Mukku, E, Canova-Davis, T, Somers, M, Cronin, M, Winkler, J A, Wells   +13 more
openaire   +2 more sources

Somatrogon in pediatric growth hormone deficiency: a comprehensive review of clinical trials and real-world considerations [PDF]

Annals of Pediatric Endocrinology & Metabolism
Growth hormone (GH) is crucial for childhood growth and body composition. In pediatric GH deficiency (pGHD), the pituitary gland fails to produce sufficient GH, which affects linear growth in childhood.
Aristides K. Maniatis, Michael P. Wajnrajch, Marc Thomas, Sung Beom Chung, Jieun Lee   +4 more
doaj   +1 more source

Long-acting beta(2)-agonist in addition to tiotropium versus either tiotropium or long-acting beta(2)-agonist alone for chronic obstructive pulmonary disease [PDF]

, 2012
BackgroundLong-acting bronchodilators comprising long-acting beta(2)-agonists and the anticholinergic agent tiotropium are commonly used for managing persistent symptoms of chronic obstructive pulmonary disease.
Christopher J Cates, Karner, C, Cates, CJ, Charlotta Karner   +3 more
core   +1 more source

Once-Weekly Somatrogon in Pediatric Growth Hormone Deficiency: Real-World Efficacy, Safety, and Quality-of-Life Findings

JCRPE
Objective: To report real-world 6- and 12-month outcomes in children with growth hormone deficiency (GHD) treated with somatrogon or somatropin, including those who transitioned from somatropin to somatrogon.
Kübra Şen Küçük, Sebla Güneş, Mustafa Dinçer, Sercan Öztürk, Tolga Ünüvar, Ahmet Anık   +5 more
doaj   +1 more source