Results 41 to 50 of about 12,197,984 (249)
Developing long‐acting growth hormone formulations [PDF]
Clinical Endocrinology, 2013 SummaryDaily recombinant growth hormone (GH) restores normal growth and body composition in GH‐deficient children and adults; however, daily injections are inconvenient and can be distressing for some children. On top of this compliance is a problem in up to 75% of children.
Pippa, Cawley +2 more
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, 2022 Long-acting growth hormone (LAGH) is emerging to be a new preparation for treatment of short stature. We aimed to determine whether 12-month treatment with LAGH in patients with idiopathic short stature has an effect on the nocturnal endogenous growth ...
김호성 +11 more
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Long-Acting Growth Hormone Preparations in the Treatment of Children. [PDF]
Pediatr Endocrinol Rev, 2018 Human growth hormone (hGH), which had been in use since 1958, was supplanted by recombinant human growth hormone (rhGH) in 1985 for those with growth hormone deficiency (GHD). Adherence to daily subcutaneous growth hormone is challenging for patients. Thus, several companies have pursued the creation of long acting rhGH.
Lal RA, Hoffman AR.
europepmc +3 more sources
Long-Acting Growth Hormone Preparations - Current Status and Future Considerations.
J Clin Endocrinol Metab, 2020 Miller BS, Velazquez E, Yuen KCJ.
europepmc +2 more sources
The rationale and design of TransCon Growth Hormone for the treatment of growth hormone deficiency
Endocrine Connections, 2017 The fundamental challenge of developing a long-acting growth hormone (LAGH) is to create a more convenient growth hormone (GH) dosing profile while retaining the excellent safety, efficacy and tolerability of daily GH.
Kennett Sprogøe +3 more
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Growth hormone receptor agonists and antagonists: From protein expression and purification to long‐acting formulations [PDF]
, 2023 Recombinant human growth hormone (rhGH) and GH receptor antagonists (GHAs) are used clinically to treat a range of disorders associated with GH deficiency or hypersecretion, respectively.
Maynard, Heather D +11 more
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Human Growth and Growth Hormone: From Antiquity to the Recominant Age to the Future
Frontiers in Endocrinology, 2021 Since antiquity Man has been fascinated by the variations in human (and animal) growth. Stories and art abound about giants and little people. Modern genetics have solved some of etiologies at both extremes of growth.
Evan Graber +2 more
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Somatrogon in pediatric growth hormone deficiency: a comprehensive review of clinical trials and real-world considerations [PDF]
Annals of Pediatric Endocrinology & MetabolismGrowth hormone (GH) is crucial for childhood growth and body composition. In pediatric GH deficiency (pGHD), the pituitary gland fails to produce sufficient GH, which affects linear growth in childhood.
Aristides K. Maniatis +4 more
doaj +1 more source
Long-acting Growth Hormones Produced by Conjugation with Polyethylene Glycol [PDF]
Journal of Biological Chemistry, 1996 Derivatives of human growth hormone (hGH) of increasing size were produced by reaction with the N-hydroxysuccinimide ester of polyethylene glycol-5000 (PEG5000), a 5-kDa reagent that selectively conjugates to primary amines. By adjusting the reaction conditions and purification procedure, it was possible to isolate hGH derivatives containing up to ...
R, Clark +13 more
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JCRPEObjective: To report real-world 6- and 12-month outcomes in children with growth hormone deficiency (GHD) treated with somatrogon or somatropin, including those who transitioned from somatropin to somatrogon.
Kübra Şen Küçük +5 more
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