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Somatrogon in pediatric growth hormone deficiency: a comprehensive review of clinical trials and real-world considerations [PDF]
Annals of Pediatric Endocrinology & MetabolismGrowth hormone (GH) is crucial for childhood growth and body composition. In pediatric GH deficiency (pGHD), the pituitary gland fails to produce sufficient GH, which affects linear growth in childhood.
Aristides K. Maniatis +4 more
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Long-acting Growth Hormones Produced by Conjugation with Polyethylene Glycol [PDF]
Journal of Biological Chemistry, 1996 Derivatives of human growth hormone (hGH) of increasing size were produced by reaction with the N-hydroxysuccinimide ester of polyethylene glycol-5000 (PEG5000), a 5-kDa reagent that selectively conjugates to primary amines. By adjusting the reaction conditions and purification procedure, it was possible to isolate hGH derivatives containing up to ...
R, Clark +13 more
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Frontiers in Endocrinology, 2022 ObjectivesTo investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of Y-shape branched PEGylated recombinant human growth hormone (YPEG-rhGH) and evaluate its short-term efficacy and safety in children with growth hormone deficiency (GHD ...
Yan Liang +15 more
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Frontiers in Endocrinology, 2023 IntroductionThe standard of care for pediatric growth hormone deficiency (pGHD) is once-daily recombinant human growth hormone (rhGH). Somatrogon, a long-acting rhGH, requires less frequent, once-weekly, dosing.
Roy Gomez +8 more
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Somatostatin agonist pasireotide inhibits exercise stimulated growth in the male Siberian hamster (Phodopus sungorus) [PDF]
, 2017 R.Dumbell was supported by a University of Aberdeen PhD studentship and a research visit grant awarded by the British Society of Neuroendocrinology. Further support was provided by the Scottish Government Rural and Environment Science and Analytical ...
Barrett, P +6 more
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Drug Design, Development and Therapy, 2022 Bradley S Miller,1 Kevin CJ Yuen2 1Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, MN, USA; 2Department of Neuroendocrinology and Neurology, Barrow Pituitary Center, University of Arizona College of Medicine and Creighton ...
Miller BS, Yuen KCJ
doaj
Growth hormone plus resistance exercise attenuate structural changes in rat myotendinous junctions resulting from chronic unloading. [PDF]
, 2013 Myotendinous junctions (MTJs) are specialized sites on the muscle surface where forces generated by myofibrils are transmitted across the sarcolemma to the extracellular matrix.
Burattini, S +8 more
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Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]
, 1994 The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Brockmeier, S. +7 more
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Long-Acting Growth Hormone for Replacement Therapy [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2011 GH replacement therapy has shown important beneficial effects on body composition, bone metabolism, lipid metabolism, and quality of life in adults with GH deficiency with a good safety profile (1, 2). Current management is based on daily sc injections before bedtime that are often experienced as cumbersome by the patient and may therefore affect ...
openaire +1 more source