Long-acting growth hormone therapy in paediatric growth hormone deficiency: reduced treatment burden and unproven motivation-related neuroendocrine effects [PDF]
Frontiers in EndocrinologyLong-acting growth hormone (LAGH) formulations represent an important therapeutic advance in the management of growth hormone deficiency (GHD) because they reduce injection frequency and treatment burden and may improve adherence and patient-reported ...
Rossella Gaudino +7 more
doaj +2 more sources
Long-acting growth hormone for pediatric GHD: insights into molecular modification and clinical application [PDF]
Frontiers in EndocrinologyLong-acting growth hormone (LAGH) therapies represent a paradigm shift in the management of growth hormone deficiency (GHD), alleviating the burden of daily injections.
Jianyang Gu +3 more
doaj +2 more sources
Long-acting growth hormone in the treatment of growth hormone deficiency in children: a systematic literature review and network meta-analysis [PDF]
Scientific ReportsThe purpose of this study is to compare the relative efficacy and safety of long-acting growth hormone (LAGH) as a growth hormone replacement therapy in prepubertal children with growth hormone deficiency (GHD).
Jianfang Zhu +6 more
doaj +2 more sources
Severe Lipoatrophy in a Growth Hormone Deficient Toddler Girl Treated with a Non-Pegylated Long-Acting Growth Hormone [PDF]
ChildrenBackground: Recombinant growth hormone (rhGH) has been used since 1985 to treat growth hormone (GH)-induced short stature, typically associated with transient adverse events. However, lipoatrophy, characterized by irreversible damage to subcutaneous fat,
Atilla Büyükgebiz, And Demir
doaj +2 more sources
Real-World Canadian Insights into Pediatric Growth Hormone Deficiency: Perspectives on Daily and Long-Acting Growth Hormone from Patients, Caregivers, and Healthcare Providers [PDF]
Patient Preference and AdherenceDavid Nguyen,1 Ufuk Coşkun,2 Chantal Cadieux,1 Jamie Harvey,3 Olga Moshkovich,2 Neha Durgam,2 M. Alex Bellenger,2 Vicky Turner,4 Duygu Alpan,2 Triza Brion21Pfizer, Kirkland, Quebec, Canada; 2ICON Clinical Research, Blue Bell, PA, USA; 3The ...
Nguyen D +9 more
doaj +2 more sources
New directions in growth hormone treatment in children
Pediatric Endocrinology, Diabetes and MetabolismThis paper reviews clinical-trial evidence on the use of long-acting growth hormone (LAGH) preparations in children. Three LAGH products have been approved in Europe and the United States for paediatric growth hormone deficiency (GHD): lonapegsomatropin,
Renata Stawerska
doaj +2 more sources
Corrigendum: Usefulness and Potential Pitfalls of Long-Acting Growth Hormone Analogues [PDF]
Frontiers in Endocrinology, 2021 Kevin C. J. Yuen +3 more
doaj +2 more sources
Long-Acting Growth Hormone Preparations in the Treatment of Children. [PDF]
Pediatr Endocrinol Rev, 2018 Human growth hormone (hGH), which had been in use since 1958, was supplanted by recombinant human growth hormone (rhGH) in 1985 for those with growth hormone deficiency (GHD). Adherence to daily subcutaneous growth hormone is challenging for patients. Thus, several companies have pursued the creation of long acting rhGH.
Lal RA, Hoffman AR.
europepmc +3 more sources
Preclinical Investigations of a Novel PEGylated Long-Acting Human Growth Hormone
Drug Design, Development and TherapyJun Wang,1,2 He Wang,1,2 Rong Wang,1,2 Yu Zhuang,1,2 Chenyang Jiang,1,2 Baixue Zhao,1,2 Zhen Xu,1,2 Bruce Yong Ma1,2 1Zonhon Biopharma Institute, Inc., Changzhou, Jiangsu, People’s Republic of China; 2Jiangsu Engineering Research Center for Precision ...
Wang J +7 more
doaj +3 more sources
A phase 2 trial of long-acting TransCon growth hormone in adult GH deficiency
Endocrine Connections, 2017 TransCon growth hormone is a sustained-release human growth hormone prodrug under development in which unmodified growth hormone is transiently linked to a carrier molecule.
Charlotte Höybye +8 more
doaj +2 more sources