Results 31 to 40 of about 11,495,017 (246)

Long-Acting Growth Hormone Preparations - Current Status and Future Considerations.

J Clin Endocrinol Metab, 2020
AbstractContextLong-acting GH (LAGH) preparations are currently being developed in an attempt to improve adherence. The profile of GH action following administration of LAGH raises practical questions about clinical monitoring and long-term safety and efficacy of these new therapeutic agents.MethodsRecent literature and meeting proceedings regarding ...
Miller BS, Velazquez E, Yuen KCJ.
europepmc   +4 more sources

Discovery and optimization of a pH-responsive ultra-long-acting VHH-based growth hormone mimetic [PDF]

mAbs
Weekly formulations of long-acting growth hormone (LAGH) effectively treat growth hormone (GH) deficiency in both children and adults while offering improved convenience compared to daily GH.
Houcong Jin, Gao Sun, Hongxia Shen, Qian Hao, Lanlan Chen, Chong Che, Xiaoyu Gu, Tong Wang, Nizhi Wang, Fangfang Du, Qingjuan Ma, Peng Qi, Mengyao An, Xuemei Liao, Xiaozhen Wang, Siqin Wang, Lei Jin, Lishan Kang   +17 more
doaj   +2 more sources

Corrigendum: Guidance for the treatment of adult growth hormone deficiency with somapacitan, a long-acting growth hormone preparation [PDF]

Frontiers in Endocrinology, 2023
Martin Bidlingmaier, Beverly M.K. Biller, David Clemmons, Jens Otto L. Jørgensen, Hiroshi Nishioka, Yutaka Takahashi, Yutaka Takahashi   +6 more
doaj   +2 more sources

A Cell-Based Strategy for Bioactivity Determination of Long-Acting Fc-Fusion Recombinant Human Growth Hormone

Molecules, 2019
The long-acting growth hormone (LAGH) is a promising alternative biopharmaceutical to treat growth hormone (GH) deficiency in children, and it was developed using a variety of technologies by several pharmaceutical companies. Most LAGH preparations, such
Wenrong Yao, Lei Yu, Wenhong Fan, Xinchang Shi, Lan Liu, Yonghong Li, Xi Qin, Chunming Rao, Junzhi Wang   +8 more
doaj   +3 more sources

Long-acting growth hormones: innovations in treatment and guidance on patient selection in pediatric growth hormone deficiency [PDF]

Annals of Pediatric Endocrinology & Metabolism
Long-acting growth hormones (LAGHs) represent a significant advancement in the treatment of pediatric GH deficiency, offering an alternative to daily recombinant human GH (rhGH) therapy.
Chiara Rodaro, Gianluca Tamaro, Elena Faleschini, Gianluca Tornese   +3 more
doaj   +4 more sources

First Clinical Study on Long-Acting Growth Hormone Therapy in Children with Turner Sydrome. [PDF]

Horm Metab Res, 2022
Gao X, Chen J, Cao B, Dou X, Peng Y, Su C, Qin M, Wei L, Fan L, Zhang B, Gong C.   +10 more
europepmc   +2 more sources

Molecular Dynamics Simulation and Characterization of GelMA/HA Composite Microneedles for Potential Growth Hormone Transdermal Delivery [PDF]

Gels
To overcome the limitations of repeated GH injection therapy, gelatin methacryloyl (GelMA)/hyaluronic acid (HA) composite hydrogel microneedles were fabricated for potential non-invasive transdermal delivery of recombinant human growth hormone (rhGH) and
Jianyang Gu, Hao Zhang, Han Liu, Binghuai Peng, Yongbo Qiao, Ping Gong   +5 more
doaj   +2 more sources

Retraction: Effect of weekly long-acting growth hormone replacement therapy compared to daily growth hormone on children with short stature: a meta-analysis [PDF]

Frontiers in Endocrinology, 2023
Frontiers Editorial Office
doaj   +2 more sources

Long-Acting Growth Hormone [PDF]

Pediatric Drugs, 2013
Human growth hormone (GH) is a 22 kDa protein synthesized and secreted in the anterior pituitary gland. GH synthesis and release is induced by hypothalamic GHreleasing hormone (GHRH) and ghrelin and attenuated by somatostatin and negative feedback by insulin-like growth factor (IGF)-I [1].
Höybye, Charlotte, Christiansen, Jens Sandahl   +1 more
openaire   +3 more sources

Long-acting Growth Hormone Therapy: A REAL3 Alternative to Daily Growth Hormone Treatment?

Journal of Clinical Endocrinology and Metabolism, 2020
Michael A Levine, Michael A Levine, Vaneeta Bamba   +2 more
exaly   +3 more sources