Results 31 to 40 of about 79,477 (216)

Long-Acting Growth Hormone [PDF]

Pediatric Drugs, 2013
Human growth hormone (GH) is a 22 kDa protein synthesized and secreted in the anterior pituitary gland. GH synthesis and release is induced by hypothalamic GHreleasing hormone (GHRH) and ghrelin and attenuated by somatostatin and negative feedback by insulin-like growth factor (IGF)-I [1].
Höybye, Charlotte, Christiansen, Jens Sandahl   +1 more
openaire   +3 more sources

Can long-acting growth hormone improve adherence in pediatric growth hormone deficiency? [PDF]

Endocrine
Abstract Growth hormone deficiency (GHD) in childhood and adolescence requires long-term therapy with recombinant human growth hormone (rhGH). Although daily injections are highly effective, they impose a considerable treatment burden that often leads to suboptimal adherence and compromised growth outcomes.
Rodaro C, Tamaro G, Fachin A, Nicolardi F, Tommasi S, Tornese G.   +5 more
europepmc   +3 more sources

Long-Acting Growth Hormone Preparations in the Treatment of Children. [PDF]

Pediatr Endocrinol Rev, 2018
Lal RA, Hoffman AR.
europepmc   +2 more sources

Developing long‐acting growth hormone formulations [PDF]

Clinical Endocrinology, 2013
SummaryDaily recombinant growth hormone (GH) restores normal growth and body composition in GH‐deficient children and adults; however, daily injections are inconvenient and can be distressing for some children. On top of this compliance is a problem in up to 75% of children.
Pippa, Cawley, Ian, Wilkinson, Richard J, Ross   +2 more
openaire   +2 more sources

Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations. [PDF]

Eur J Endocrinol, 2016
Objective The Growth Hormone (GH) Research Society (GRS) convened a workshop to address important issues regarding trial design, efficacy, and safety of long-acting growth hormone preparations (LAGH). Participants A closed meeting of 55 international scientists with expertise in GH, including pediatric and adult endocrinologists, basic scientists ...
Christiansen JS, Backeljauw PF, Bidlingmaier M, Biller BM, Boguszewski MC, Casanueva FF, Chanson P, Chatelain P, Choong CS, Clemmons DR, Cohen LE, Cohen P, Frystyk J, Grimberg A, Hasegawa Y, Haymond MW, Ho K, Hoffman AR, Holly JM, Horikawa R, Höybye C, Jorgensen JO, Johannsson G, Juul A, Katznelson L, Kopchick JJ, Lee KO, Lee KW, Luo X, Melmed S, Miller BS, Misra M, Popovic V, Rosenfeld RG, Ross J, Ross RJ, Saenger P, Strasburger CJ, Thorner MO, Werner H, Yuen K.   +40 more
europepmc   +10 more sources

The rationale and design of TransCon Growth Hormone for the treatment of growth hormone deficiency

Endocrine Connections, 2017
The fundamental challenge of developing a long-acting growth hormone (LAGH) is to create a more convenient growth hormone (GH) dosing profile while retaining the excellent safety, efficacy and tolerability of daily GH.
Kennett Sprogøe, Eva Mortensen, David B Karpf, Jonathan A Leff   +3 more
doaj   +1 more source

Long-acting Growth Hormones Produced by Conjugation with Polyethylene Glycol [PDF]

Journal of Biological Chemistry, 1996
Derivatives of human growth hormone (hGH) of increasing size were produced by reaction with the N-hydroxysuccinimide ester of polyethylene glycol-5000 (PEG5000), a 5-kDa reagent that selectively conjugates to primary amines. By adjusting the reaction conditions and purification procedure, it was possible to isolate hGH derivatives containing up to ...
R, Clark, K, Olson, G, Fuh, M, Marian, D, Mortensen, G, Teshima, S, Chang, H, Chu, V, Mukku, E, Canova-Davis, T, Somers, M, Cronin, M, Winkler, J A, Wells   +13 more
openaire   +2 more sources

Human Growth and Growth Hormone: From Antiquity to the Recominant Age to the Future

Frontiers in Endocrinology, 2021
Since antiquity Man has been fascinated by the variations in human (and animal) growth. Stories and art abound about giants and little people. Modern genetics have solved some of etiologies at both extremes of growth.
Evan Graber, Edward O. Reiter, Alan D. Rogol   +2 more
doaj   +1 more source

Somatrogon in pediatric growth hormone deficiency: a comprehensive review of clinical trials and real-world considerations [PDF]

Annals of Pediatric Endocrinology & Metabolism
Growth hormone (GH) is crucial for childhood growth and body composition. In pediatric GH deficiency (pGHD), the pituitary gland fails to produce sufficient GH, which affects linear growth in childhood.
Aristides K. Maniatis, Michael P. Wajnrajch, Marc Thomas, Sung Beom Chung, Jieun Lee   +4 more
doaj   +1 more source

Once-Weekly Somatrogon in Pediatric Growth Hormone Deficiency: Real-World Efficacy, Safety, and Quality-of-Life Findings

JCRPE
Objective: To report real-world 6- and 12-month outcomes in children with growth hormone deficiency (GHD) treated with somatrogon or somatropin, including those who transitioned from somatropin to somatrogon.
Kübra Şen Küçük, Sebla Güneş, Mustafa Dinçer, Sercan Öztürk, Tolga Ünüvar, Ahmet Anık   +5 more
doaj   +1 more source