Developing long‐acting growth hormone formulations [PDF]
Clinical Endocrinology, 2013 SummaryDaily recombinant growth hormone (GH) restores normal growth and body composition in GH‐deficient children and adults; however, daily injections are inconvenient and can be distressing for some children. On top of this compliance is a problem in up to 75% of children.
Pippa, Cawley +2 more
openaire +2 more sources
Characterisation of the ERF102 to ERF105 genes of Arabidopsis thaliana and their role in the response to cold stress [PDF]
, 2020 The ETHYLENE RESPONSE FACTOR (ERF) genes of Arabidopsis thaliana form a large family encoding plant-specific transcription factors. Here, we characterise the four phylogenetically closely related ERF102/ERF5, ERF103/ERF6, ERF104 and ERF105 genes ...
Hincha, Dirk K. +4 more
core +1 more source
Optimizing Patient Management and Adherence for Children Receiving Growth Hormone. [PDF]
, 2017 Poor adherence with growth hormone (GH) therapy has been associated with worse clinical outcomes, which in children relates specifically to their linear growth and loss of quality of life.
Carlo L. Acerini +3 more
core +3 more sources
The rationale and design of TransCon Growth Hormone for the treatment of growth hormone deficiency
Endocrine Connections, 2017 The fundamental challenge of developing a long-acting growth hormone (LAGH) is to create a more convenient growth hormone (GH) dosing profile while retaining the excellent safety, efficacy and tolerability of daily GH.
Kennett Sprogøe +3 more
doaj +1 more source
Pasireotide for the Medical Management of Feline Hypersomatotropism [PDF]
, 2015 BACKGROUND: Feline hypersomatotropism (HST) is a cause of diabetes mellitus in cats. Pasireotide is a novel multireceptor ligand somatostatin analog that improves biochemical control of humans with HST.
Abraham +45 more
core +2 more sources
Endocrinologic Control of Men's Sexual Desire and Arousal/Erection [PDF]
, 2016 Several hormones and neurotransmitters orchestrate men's sexual response, including the appetitive (sexual desire) and consummative (arousal and penile erection) phases.
Aversa, Antonio +4 more
core +1 more source
Pasireotide Long-Acting Release Treatment for Diabetic Cats with Underlying Hypersomatotropism [PDF]
, 2017 BACKGROUND: Long‐term medical management of hypersomatotropism (HS) in cats has proved unrewarding. Pasireotide, a novel somatostatin analogue, decreases serum insulin‐like growth factor 1 (IGF‐1) and improves insulin sensitivity in cats with HS when ...
Abraham +43 more
core +3 more sources
Human Growth and Growth Hormone: From Antiquity to the Recominant Age to the Future
Frontiers in Endocrinology, 2021 Since antiquity Man has been fascinated by the variations in human (and animal) growth. Stories and art abound about giants and little people. Modern genetics have solved some of etiologies at both extremes of growth.
Evan Graber +2 more
doaj +1 more source
Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat [PDF]
, 2017 Hyperthyroidism (HyperT) compromises pregnancy and lactation, hindering suckling-induced PRL release. We studied the effect of HyperT on hypothalamic mRNA (RT-qPCR) and protein (Western blot) expression of tyrosine hydroxylase (TH), PRL receptor (PRLR ...
Jahn, Graciela Alma +4 more
core +1 more source
Homeostasis as the Mechanism of Evolution. [PDF]
, 2015 Homeostasis is conventionally thought of merely as a synchronic (same time) servo-mechanism that maintains the status quo for organismal physiology. However, when seen from the perspective of developmental physiology, homeostasis is a robust, dynamic ...
Torday, John S
core +2 more sources