Results 11 to 20 of about 11,495,017 (246)

Can long-acting growth hormone improve adherence in pediatric growth hormone deficiency? [PDF]

Endocrine
Abstract Growth hormone deficiency (GHD) in childhood and adolescence requires long-term therapy with recombinant human growth hormone (rhGH). Although daily injections are highly effective, they impose a considerable treatment burden that often leads to suboptimal adherence and compromised growth outcomes.
Rodaro C, Tamaro G, Fachin A, Nicolardi F, Tommasi S, Tornese G.   +5 more
europepmc   +4 more sources

Long-Acting Growth Hormone Therapy in Pediatric Growth Hormone Deficiency: A Consensus Statement.

J Clin Endocrinol Metab
Abstract Context Several long-acting growth hormone (LAGH) therapies have recently become available, but guidance on their usage in children with growth hormone (GH) deficiency is limited. Methods International experts in pediatric ...
Maniatis A, Cutfield W, Dattani M, Deal C, Collett-Solberg PF, Horikawa R, Maghnie M, Miller BS, Polak M, Sävendahl L, Woelfle J.   +10 more
europepmc   +4 more sources

Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations. [PDF]

Eur J Endocrinol, 2016
Objective The Growth Hormone (GH) Research Society (GRS) convened a workshop to address important issues regarding trial design, efficacy, and safety of long-acting growth hormone preparations (LAGH). Participants A closed meeting of 55 international scientists with expertise in GH, including pediatric and adult endocrinologists, basic scientists ...
Christiansen JS, Backeljauw PF, Bidlingmaier M, Biller BM, Boguszewski MC, Casanueva FF, Chanson P, Chatelain P, Choong CS, Clemmons DR, Cohen LE, Cohen P, Frystyk J, Grimberg A, Hasegawa Y, Haymond MW, Ho K, Hoffman AR, Holly JM, Horikawa R, Höybye C, Jorgensen JO, Johannsson G, Juul A, Katznelson L, Kopchick JJ, Lee KO, Lee KW, Luo X, Melmed S, Miller BS, Misra M, Popovic V, Rosenfeld RG, Ross J, Ross RJ, Saenger P, Strasburger CJ, Thorner MO, Werner H, Yuen K.   +40 more
europepmc   +11 more sources

Long-Acting Growth Hormone Preparations and Their Use in Children with Growth Hormone Deficiency [PDF]

Hormone Research in Paediatrics, 2022
<b><i>Background:</i></b> Daily recombinant human growth hormone (rhGH) is approved and marketed worldwide to treat children and adults with GH deficiency and other conditions. Efficacy of rhGH therapy is influenced by several variables.
Pampanini, Valentina, Deodati, Annalisa, Inzaghi, Elena, Cianfarani, Stefano   +3 more
openaire   +4 more sources

Long-Acting Growth Hormone Versus Daily Growth Hormone for Growth Hormone Deficiency Patients: A Network Meta-Analysis of Clinical Trials. [PDF]

Endocrinol Diabetes Metab
In recent years, the landscape of growth hormone deficiency treatment has been revolutionized by the approval and commercial availability of several distinct Long-acting Growth Hormone (LAGH) formulations, each designed for once-weekly administration ...
Abadi A, Ghanem U, Ghanem H, Sawafta AJ, Abulehia A, Ataya M, Nairat R, Sammour AM, Ayesh H.   +8 more
europepmc   +10 more sources

Efficacy, safety, quality of life, adherence and cost-effectiveness of long-acting growth hormone replacement therapy compared to daily growth hormone in children with growth hormone deficiency: A systematic review and meta-analysis

Pharmacological Research, 2023
We evaluated the efficacy, safety, adherence, quality of life (QoL) and cost-effectiveness of long-acting growth hormone (LAGH) vs daily growth hormone (GH) preparations in the treatment of growth hormone deficiency (GHD) in children. Systematic searches
Chiara Mameli, Massimiliano Orso, Valeria Calcaterra, Malgorzata Gabriela Wasniewska, Tommaso Aversa, Simona Granato, Pietro Bruschini, Liliana Guadagni, Daniela d’Angela, Federico Spandonaro, Barbara Polistena, Gianvincenzo Zuccotti   +11 more
doaj   +3 more sources

RETRACTED: Effect of Weekly Long-Acting Growth Hormone Replacement Therapy Compared to Daily Growth Hormone on Children With Short Stature: A Meta-Analysis

Frontiers in Endocrinology, 2021
BackgroundWe performed a meta-analysis to evaluate the efficacy and safety of weekly long-acting growth hormone replacement therapy compared to daily growth hormone in children with short stature.MethodsA systematic literature search up to April 2021 was
Liyan Ma, Liangyi Li, Wen Pan, Congfu Huang, Limei Liu, Xiaoxiao Zhang, Xiaoxiao Zhang   +6 more
doaj   +2 more sources

Effects of different doses of long-acting growth hormone in treating children with growth hormone deficiency. [PDF]

World J Clin Cases, 2023
β cells are the main cells responsible for the hypoglycemic function of pancreatic islets, and the insulin secreted by these cells is the only hormone that lowers blood glucose levels in the human body. β cells are regulated by various factors, among which neurotransmitters make an important contribution.
Xia W, Wang T, Pan JY.
europepmc   +3 more sources

Treatment of a case with short stature and Goltz syndrome with long-acting growth hormone: a case report and follow-up [PDF]

BMC Pediatrics
Goltz syndrome, also known as focal dermal hypoplasia, is an X-linked dominant genetic disorder caused by mutations in the PORCN gene, mainly characterized by developmental impairments affecting the skin, hair, bones, teeth, and eyes.
Jinghui Zhang, Nana Qiao, Xiaochun Li
doaj   +2 more sources

Comparison of efficacy and safety between long-acting growth hormone and short-acting growth hormone in isolated growth hormone deficiency: a systematic review and meta-analysis of 16 randomized controlled trials involving 2,435 pediatric patients [PDF]

Frontiers in Pediatrics
ObjectiveTo comprehensively compare the efficacy and safety of long-acting human growth hormone (LAGH) preparations with conventional short-acting daily growth hormone (SA-GH) in children with isolated growth hormone deficiency (GHD), and explore ...
Zhen-Zhen Shen, Yun Huang, Li-Li Wu, Jian-Su Zhang, Xiao-Xia Zhang   +4 more
doaj   +2 more sources