Results 61 to 70 of about 8,328,477 (294)

Haplotype‐Resolved Genotyping and Association Analysis of 1,020 β‐Thalassemia Patients by Targeted Long‐Read Sequencing

Advanced Science
Despite the well‐documented mutation spectra of β‐thalassemia, the genetic variants and haplotypes of globin gene clusters modulating its clinical heterogeneity remain incompletely illustrated.
Yuhua Ye, Chao Niu, Aiping Mao, Lang Qin, Jiahan Zhan, Weijie Chen, Zhentian Liu, Tiantian Xie, Qianqian Zhang, Jiaqi Li, Li Huang, Wanli Meng, Yumeng Liu, Liuhua Liao, Junqin Cai, Riyang Liu, Xinhua Zhang, Lihong Zeng, Yaoyun Li, Bin Lin, Kui Li, Xiaoyun Hua, Binbin Huang, Honggui Qin, Yueyan Huang, Zhijing Huang, Jinquan Lao, Xiang Qu, Juanjuan Chen, Xiaoqin Feng, Qiujun Liu, Wanying Lin, Xiaoman Zhou, Yidan Liang, Xingjiang Long, Jiaofeng Qin, Lixiang Yan, Weijian Zhu, Lian Yu, Chengwu Fan, Deguo Tang, Tianyu Zhong, Jufang Tan, Zhilin Ren, Xiangmin Xu   +44 more
doaj   +1 more source

High-throughput annotation of full-length long noncoding RNAs with capture long-read sequencing [PDF]

, 2017
Accurate annotation of genes and their transcripts is a foundation of genomics, but currently no annotation technique combines throughput and accuracy.
Abad, Amaya, Barbara Uszczynska-Ratajczak, Thomas R Gingeras, Lagarde, J., Sílvia Pérez-Lluch, Gingeras, Thomas R, Lagarde, Julien, Johnson, R., Jennifer Harrow, Uszczynska-Ratajczak, Barbara, Silvia Carbonell, Guigó Serra, Roderic, Gingeras, T. R., Amaya Abad, Frankish, Adam, Davis, C., Uszczynska-Ratajczak, B., Frankish, A., Carrie Davis, Pérez-Lluch, Sílvia, Gingeras, Thomas R., Adam Frankish, Perez-Lluch, S., Guigo, R., Julien Lagarde, Harrow, J., Carbonell, Silvia, Rory Johnson, Harrow, Jennifer, Davis, Carrie, Johnson, Rory, Guigo, Roderic, Roderic Guigo, Carbonell, S., Davis, Carrie A., Abad, A.   +35 more
core   +3 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The Application of Long-Read Sequencing to Cancer

Cancers
Cancer is a multifaceted disease arising from numerous genomic aberrations that have been identified as a result of advancements in sequencing technologies. While next-generation sequencing (NGS), which uses short reads, has transformed cancer research and diagnostics, it is limited by read length.
Luca Ermini, Patrick Driguez
openaire   +4 more sources

long

, 2020
simulated long read ...
Hossein Asghari (8506854)
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Ultralow-input single-tube linked-read library method enables short-read second-generation sequencing systems to routinely generate highly accurate and economical long-range sequencing information [PDF]

, 2020
Long-range sequencing information is required for haplotype phasing, de novo assembly, and structural variation detection. Current long-read sequencing technologies can provide valuable long-range information but at a high cost with low accuracy and high
Porter, Devin, Pevzner, Pavel, Chang, Peter L, Pham, Long, Phan, Tan, Bansal, Vikas, Humphrey, Greg, Knight, Rob, Lei, Ming, Wu, Tsai-Chin, Wang, Yong, Chen, Zhoutao, Pham, Son, Tran, Hao, Mo, Guoya, Shaffer, Justin, Xia, Yu, Belda-Ferre, Pedro, Che, Huu   +18 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

NanoPack: visualizing and processing long read sequencing data [PDF]

Bioinformatics, 2017
Abstract Summary: Here we describe NanoPack, a set of tools developed for visualization and processing of long read sequencing data from Oxford Nanopore Technologies and Pacific Biosciences. Availability and Implementation: The ...
De Coster, Wouter, D’Hert, Svenn, Schultz, Darrin T., Cruts, Marc, Van Broeckhoven, Christine   +4 more
openaire   +4 more sources

Revealing co-infections in pneumonia: A case report on advancing diagnosis with metagenomic sequencing technologies

Journal of Infection and Public Health
Pneumonia, a frequent and serious complication in kidney transplant recipients, is significantly increased by long-term immunosuppressive medication. This case report details a patient with lung cavitation, in which conventional microbiological methods ...
Suzan Alzeer, Reem S. Almaghrabi, Amna Magrashi, Turki Alzahrani, Razan Bakheet, Abdulmohsen Alqasabi, Hamsa Tayeb   +6 more
doaj   +1 more source