Results 1 to 10 of about 82,808 (286)

Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation [PDF]

Nature Communications
The CCKBR agonists induce neocortical long-term potentiation of excitatory synaptic transmission and enhance memory formation, while its antagonists weaken the potentiation in the amygdala and alleviate depression-like behaviors.
Heng Shi, Mengfan Zhang, Xiaofeng Hu, Jie Zhang, Tao Chen, Pingzhou Wu, Xue Wang, Shu Wei, George Choy, Stephen Temitayo Bello, Huifeng Chen, Chunhua Liu, Yiping Guo, Hongyan Sun, Jufang He   +14 more
doaj   +2 more sources

Long-term potentiation and long-term depression: a clinical perspective [PDF]

Clinics, 2011
Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system.
Timothy V.P. Bliss, Sam F. Cooke
doaj   +5 more sources

Nutritional deficit and Long Term Potentiation alterations

Journal of Biological Research, 2009
In the present work we examined the ability of prenatally malnourished offspring to produce and maintain long-term potentiation (LTP) of the perforant path/dentate granule cell synapse in freely moving rats at 15,30, and 90 days of age.
M. Petrosino, G. Pizzuti
doaj   +3 more sources

Long-Term Potentiation: The Accidental Discovery. [PDF]

Hippocampus
ABSTRACTLong‐term potentiation (LTP), is a type of synaptic plasticity now considered essential for learning and memory. Here I tell the story of how I accidentally discovered in 1966 in the laboratory of Per Andersen in Oslo, Norway, because I was not looking for it. It just emerged.
Lømo T.
europepmc   +3 more sources

The Pathway-Selective Dependence of Nitric Oxide for Long-Term Potentiation in the Anterior Cingulate Cortex of Adult Mice [PDF]

Biomedicines
Nitric oxide (NO) is a key diffusible messenger in the mammalian brain. It has been proposed that NO may diffuse in retrograde into presynaptic terminals, contributing to the induction of hippocampal long-term potentiation (LTP).
Qi-Yu Chen, Jinjin Wan, Yujie Ma, Min Zhuo   +3 more
doaj   +2 more sources

The Association of Hippocampal Long-Term Potentiation-Induced Gene Expression with Genetic Risk for Psychosis. [PDF]

Int J Mol Sci
Wellard NL, Clifton NE, Rees E, Thomas KL, Hall J.   +4 more
europepmc   +3 more sources

Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation. [PDF]

PLoS ONE, 2015
The long-term potentiation (LTP) of spinal C-fiber-evoked field potentials is considered as a fundamental mechanism of central sensitization in the spinal cord.
Chao Bian, Zhi-Qi Zhao, Yu-Qiu Zhang, Ning Lü   +3 more
doaj   +1 more source

Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity

European Journal of Cell Biology, 2023
Dendritic spines form the postsynaptic compartment of most excitatory synapses in the vertebrate brain. Morphological changes of dendritic spines contribute to major forms of synaptic plasticity such as long-term potentiation (LTP) or depression (LTD ...
Anika Heinze, Marco B. Rust
doaj   +1 more source

Long-term potentiation in isolated dendritic spines. [PDF]

PLoS ONE, 2009
BACKGROUND:In brain, N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation can induce long-lasting changes in synaptic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor (AMPAR) levels.
Amadou T Corera, Guy Doucet, Edward A Fon   +2 more
doaj   +1 more source

Core-Shell Dual-Gate Nanowire Charge-Trap Memory for Synaptic Operations for Neuromorphic Applications

Nanomaterials, 2021
This work showcases the physical insights of a core-shell dual-gate (CSDG) nanowire transistor as an artificial synaptic device with short/long-term potentiation and long-term depression (LTD) operation.
Md. Hasan Raza Ansari, Udaya Mohanan Kannan, Seongjae Cho   +2 more
doaj   +1 more source