Results 1 to 10 of about 80,618 (294)
Long-term potentiation and long-term depression: a clinical perspective [PDF]
Clinics, 2011 Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have received much attention as cellular models of information storage in the central nervous system.
Bliss, Timothy V.P., Cooke, Sam F.
openaire +7 more sources
Long-Term Potentiation: The Accidental Discovery. [PDF]
HippocampusABSTRACTLong‐term potentiation (LTP), is a type of synaptic plasticity now considered essential for learning and memory. Here I tell the story of how I accidentally discovered in 1966 in the laboratory of Per Andersen in Oslo, Norway, because I was not looking for it. It just emerged.
Lømo T.
europepmc +3 more sources
Long-Term Potentiation and Memory [PDF]
Physiological Reviews, 2004 Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004; 10.1152/physrev.00014.2003.—One of the most significant challenges in neuroscience is to identify the cellular and molecular processes that underlie learning and memory formation. The past decade has seen remarkable progress in understanding changes that accompany certain forms
Lynch, M. A., Ma, Lynch
openaire +3 more sources
Long-term potentiation in the Eocene [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2003 Abstract The first ten years of long-term potentiation (LTP) research are reviewed. Surprisingly, given the intensity of current interest, the discovery paper did not trigger a wave of follow-on experiments. Despite this, the initial work laid out what ultimately became standard questions and paradigms.
openaire +3 more sources
Long-term potentiation and memory [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2003 Abstract The discovery of long-term potentiation (LTP) transformed research on the neurobiology of learning and memory. This did not happen overnight, but the discovery of an experimentally demonstrable phenomenon reflecting activity-driven neuronal and synaptic plasticity changed discussions about what might underlie learning from ...
openaire +3 more sources
The discovery of long-term potentiation [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2003 Abstract This paper describes circumstances around the discovery of long-term potentiation (LTP). In 1966, I had just begun independent work for the degree of Dr medicinae (PhD) in Per Andersen’s laboratory in Oslo after an eighteen-month apprenticeship with him.
openaire +3 more sources
Stochastic Induction of Long-Term Potentiation and Long-Term Depression [PDF]
Scientific Reports, 2016 AbstractLong-term depression (LTD) and long-term potentiation (LTP) of granule-Purkinje cell synapses are persistent synaptic alterations induced by high and low rises of the intracellular calcium ion concentration ([Ca2+]), respectively. The occurrence of LTD involves the activation of a positive feedback loop formed by protein kinase C, phospholipase
Fábio M. Simões-de-Souza +2 more
openaire +3 more sources
A prelude to long-term potentiation [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2003 Abstract Searching for premonitory studies of hippocampal long-term potentiation (LTP), there is a paucity of data. While synaptic enhancement during repetitive activation was studied in several reports from many groups between 1955 and 1967, the reported after-effects were short, at the most lasting a few minutes.
openaire +3 more sources
Long-term potentiation: Peeling the onion [PDF]
Neuropharmacology, 2013 Since the discovery of long-term potentiation (LTP), thousands of papers have been published on this phenomenon. With this massive amount of information, it is often difficult, especially for someone not directly involved in the field, not to be overwhelmed.
Nicoll, Roger A, Roche, Katherine W
openaire +5 more sources
Dissecting the Components of Long-Term Potentiation [PDF]
The Neuroscientist, 2008 The formation of memories relies in part on plastic changes at synapses between neurons. Although the mechanisms of synaptic plasticity have been studied extensively over several decades, many aspects of this process remain controversial. The cellular locus of expression of long-term potentiation (LTP), a major form of synaptic plasticity, is one of ...
Jay A. Blundon, Stanislav S. Zakharenko
openaire +3 more sources