Functional insights into long antisense noncoding RNA Kcnq1ot1 mediated bidirectional silencing
, 2008 The prevailing view has been that noncoding antisense RNA primarily regulates the transcriptional activity of its sense counterpart, however, a subset of long noncoding antisense RNAs, such as Kcnq1ot1 and Air, have been shown to regulate the ...
Kanduri, Chandrasekhar,
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Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi-Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin. [PDF]
Adv Sci (Weinh)Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yao Y +5 more
europepmc +2 more sources
Dysregulation of lncRNAs in circulation of patients with periodontitis: results of a pilot study
BMC Oral Health, 2021 Background Periodontitis is a chronic inflammatory disorder with a complex etiology. Long non-coding RNAs (lncRNAs) have been shown to affect pathoetiology of periodontitis.
Soudeh Ghafouri-Fard +7 more
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Technology in Cancer Research & Treatment, 2020 Objective: This study aimed to investigate the correlation of long noncoding RNA plasmacytoma variant translocation 1 with clinical features and prognosis in patients with multiple myeloma.
Pei Li MD +3 more
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Assessing recent selection and functionality at long noncoding RNA loci in the mouse genome [PDF]
, 2015 This work was supported by the Biotechnology and Biological Sciences Research Council and The Wellcome Trust. A.N. was supported by the Swiss National Science Foundation (Grant: PZ00P3_142636). H.K. was supported by the European Research Council Starting
Ness, Rob W +19 more
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LINC00467: an oncogenic long noncoding RNA
Cancer Cell International, 2022 Long non-coding RNAs (lncRNAs) have been found to play essential roles in the cell proliferation, fission and differentiation, involving various processes in humans.
Xuyu Chen +6 more
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A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]
, 2008 The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad +22 more
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Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]
, 2010 For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
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Role of Related Regulatory Long Noncoding RNAs on Mammalian Spermatogenesis
Reproductive and Developmental Medicine, 2017 Long noncoding RNAs (lncRNAs) are transcribed by RNA molecules, which are longer than 200 nucleotides that lack an open reading frame of significant length and possess no obvious protein-coding capacity.
Kang-Sheng Liu +4 more
doaj +1 more source
Human cancer long non-coding RNA transcriptomes. [PDF]
PLoS ONE, 2011 Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome.
Ewan A Gibb +10 more
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