Results 31 to 40 of about 7,356,485 (255)

Expression and Functional Studies on the Noncoding RNA, PRINS. [PDF]

, 2012
PRINS, a noncoding RNA identified earlier by our research group, contributes to psoriasis susceptibility and cellular stress response. We have now studied the cellular and histological distribution of PRINS by using in situ hybridization and demonstrated
Széll Márta, Kemény Lajos, Dobozy Attila, Csörgő Sándorné Bata Zsuzsanna, Bacsa, Sarolta, Dobozy, Attila, Szegedi, Krisztina, Antal, Mária, István Németh, Krisztina Szegedi, Bacsa Sarolta, Lajos Kemény, Mária Antal, Göblös, Anikó, Széll, Márta, Sarolta Bacsa, Attila Dobozy, Németh István Balázs, Csörgő-Bata, Zsuzsanna, Anikó Göblös, Göblös Anikó, Németh, István Balázs, Márta Széll, Szegedi Krisztina, Kemény, Lajos, Antal Mária, Zsuzsanna Bata-Csörgő   +26 more
core   +1 more source

Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3

Non-Coding RNA, 2022
Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year ...
Adrienne Vancura, Alejandro H. Gutierrez, Thorben Hennig, Carlos Pulido-Quetglas, Frank J. Slack, Rory Johnson, Simon Haefliger   +6 more
doaj   +1 more source

Long Noncoding RNA: Genome Organization and Mechanism of Action

, 2017
For the last four decades, we have known that noncoding RNAs maintain critical housekeeping functions such as transcription, RNA processing, and translation.
Debosree Pal, Pal, D., Kanduri, Chandrasekhar,, Chandrasekhar Kanduri, Vijay Suresh Akhade, Akhade, Vijay Suresh,   +5 more
core   +1 more source

Long Noncoding RNA Regulation of Pluripotency

Stem Cells International, 2016
Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers.
Alessandro Rosa, Monica Ballarino
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Methodological considerations for circulating long noncoding RNA quantification [PDF]

, 2022
In the past decade, significant resources have been invested in long noncoding RNA (lncRNA) research. Despite the knowledge available, we are far from incorporation of lncRNA into clinical practice.
Devaux, Yvan, Sopić, Miron, de Gonzalo-Calvo, David, Miron Sopić, Yvan Devaux, David de Gonzalo-Calvo   +5 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Long noncoding RNA Cfast regulates cardiac fibrosis

Molecular Therapy: Nucleic Acids, 2021
Cardiac fibrosis occurs in most cardiac diseases, which reduces cardiac muscle compliance, impairs both systolic and diastolic heart function and, ultimately, leads to heart failure.
Feng Zhang, Xuyang Fu, Masaharu Kataoka, Ning Liu, Yingchao Wang, Feng Gao, Tian Liang, Xiaoxuan Dong, Jianqiu Pei, Xiaoyun Hu, Wei Zhu, Hong Yu, Douglas B. Cowan, Xinyang Hu, Zhan-Peng Huang, Jian’an Wang, Da-Zhi Wang, Jinghai Chen   +17 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source