Results 51 to 60 of about 7,356,485 (255)

LncRNA-GAS5 Inhibits Expression of miR 103 and Ameliorates the Articular Cartilage in Adjuvant-Induced Arthritis in Obese Mice

Dose-Response, 2020
We explored whether long noncoding RNA growth arrest-specific transcript 5 (LncRNA-GAS5) small interfering RNA (siRNA) reduced cartilage destruction in obese mice with adjuvant-induced arthritis.
Hongwei Chen, Chuan He, Yan Liu, Xiaolin Li, Chaoju Zhang, Qunyan Qin, Qixiong Pang   +6 more
doaj   +1 more source

Analysis RNA-seq and noncoding RNA

, 2016
RNA-Seq is an approach to transcriptome profiling that uses deep-sequencing technologies to detect and accurately quantify RNA molecules originating from a genome at a given moment in time.
Alberto Arrigoni, I. Panzeri, Raoul J. P. Bonnal, Massimiliano Pagani, V. Ranzani, R. J. P. Bonnal, Ilaria Panzeri, Valeria Ranzani, M. Pagani, G. Rossetti, A. Arrigoni, Grazisa Rossetti, Sergio Abrignani, S. Abrignani   +13 more
core   +1 more source

LncATLAS database for subcellular localization of long noncoding RNAs [PDF]

, 2017
The subcellular localization of long noncoding RNAs (lncRNAs) holds valuable clues to their molecular function. However, measuring localization of newly discovered lncRNAs involves time-consuming and costly experimental methods.
Carlevaro Fita, Joana, Palumbo, Emilio, Hermoso Pulido, Toni, Emilio Palumbo, Rory Johnson, Hermoso Pulido, Antonio, Joana Carlevaro-Fita, Guigó Serra, Roderic, Mas Ponte, David, Carlevaro-Fita, Joana, Mas-Ponte, David, Johnson, Rory, David Mas-Ponte, Roderic Guigo, Guigo, Roderic, Toni Hermoso Pulido, Carlevaro-Fita J, Mas-Ponte D, Hermoso Pulido T, Johnson R, Guigo R, Palumbo E   +21 more
core   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

ALDB: a domestic-animal long noncoding RNA database. [PDF]

PLoS ONE, 2015
Long noncoding RNAs (lncRNAs) have attracted significant attention in recent years due to their important roles in many biological processes. Domestic animals constitute a unique resource for understanding the genetic basis of phenotypic variation and ...
Aimin Li, Junying Zhang, Zhongyin Zhou, Lei Wang, Yujuan Liu, Yajun Liu   +5 more
doaj   +1 more source

Results for the classification of combined noncoding RNA datasets (ncRNAs) based on small RNA precursor potential.

, 2012
Long noncoding RNA candidates identified above were classified into four different subsets based on alignment with small RNA databases including microRNA sequences (miRNA), short hairpin forming RNA sequences (shRNA),small interfering RNA sequences ...
Karen M. McGinnis (113006), Susan Boerner (142508)   +1 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Long non-coding RNA profiling of pediatric Medulloblastoma

BMC Medical Genomics, 2020
Background Medulloblastoma (MB) is one of the most common malignant cancers in children. MB is primarily classified into four subgroups based on molecular and clinical characteristics as (1) WNT (2) Sonic-hedgehog (SHH) (3) Group 3 (4) Group 4. Molecular
Varun Kesherwani, Mamta Shukla, Don W. Coulter, J. Graham Sharp, Shantaram S. Joshi, Nagendra K. Chaturvedi   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

PVT1 Long Non-coding RNA in Gastrointestinal Cancer

Frontiers in Oncology, 2020
Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease.
Águeda Martínez-Barriocanal, Águeda Martínez-Barriocanal, Diego Arango, Diego Arango, Higinio Dopeso   +4 more
doaj   +1 more source