Results 61 to 70 of about 672,449 (294)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Merging short and stranded long reads improves transcript assembly.

PLoS Computational Biology, 2023
Long-read RNA sequencing has arisen as a counterpart to short-read sequencing, with the potential to capture full-length isoforms, albeit at the cost of lower depth.
Amoldeep S Kainth, Gabriela A Haddad, Johnathon M Hall, Alexander J Ruthenburg   +3 more
doaj   +1 more source

Sequencing the transcriptome of R570 to explore the complexity of the sugarcane genome [W1019] [PDF]

, 2020
Sugarcane is a crop of unequivocal importance which can meet requirements for food, feed fiber and fuel. This crop, with a large wealth of genetic resources and a rich breeding history, has only a very nascent genomic history with a monoploid genome ...
Aitken, Karen S., Barry, Kerrie W., Botha, Frikkie, D'Hont, Angélique, Furtado, Agnelo, Grimwood, Jane, Healey, Adam, Henry, Robert, Karabian Masouleh, Ardy, Kumar Pazhany, Adhini Sudhindra, O'Keeffe, Angela, Perlo, Virginie, Schmutz, Jeremy   +12 more
core  

Revealing co-infections in pneumonia: A case report on advancing diagnosis with metagenomic sequencing technologies

Journal of Infection and Public Health
Pneumonia, a frequent and serious complication in kidney transplant recipients, is significantly increased by long-term immunosuppressive medication. This case report details a patient with lung cavitation, in which conventional microbiological methods ...
Suzan Alzeer, Reem S. Almaghrabi, Amna Magrashi, Turki Alzahrani, Razan Bakheet, Abdulmohsen Alqasabi, Hamsa Tayeb   +6 more
doaj   +1 more source

Partial bisulfite conversion for unique template sequencing [PDF]

, 2018
We introduce a new protocol, mutational sequencing or muSeq, which uses sodium bisulfite to randomly deaminate unmethylated cytosines at a fixed and tunable rate.
Forcier, T., Kumar, V., Levy, D., Ronemus, M., Rosenbaum, J., Wang, Z., Wigler, M.   +6 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Long-Reads-Based Metagenomics in Clinical Diagnosis With a Special Focus on Fungal Infections

Frontiers in Microbiology, 2022
Identification of the causative infectious agent is essential in the management of infectious diseases, with the ideal diagnostic method being rapid, accurate, and informative, while remaining cost-effective.
Minh Thuy Vi Hoang, Minh Thuy Vi Hoang, Laszlo Irinyi, Laszlo Irinyi, Laszlo Irinyi, Yiheng Hu, Benjamin Schwessinger, Wieland Meyer, Wieland Meyer, Wieland Meyer, Wieland Meyer   +10 more
doaj   +1 more source

Inference of Markovian Properties of Molecular Sequences from NGS Data and Applications to Comparative Genomics [PDF]

, 2015
Next Generation Sequencing (NGS) technologies generate large amounts of short read data for many different organisms. The fact that NGS reads are generally short makes it challenging to assemble the reads and reconstruct the original genome sequence. For
Cannon, Charles H., Deng, Minghua, Reinert, Gesine, Ren, Jie, Song, Kai, Sun, Fengzhu   +5 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Benchmarking datasets for assembly-based variant calling using high-fidelity long reads

BMC Genomics, 2023
Background Recent advances in long-read sequencing technologies have enabled accurate identification of all genetic variants in individuals or cells; this procedure is known as variant calling.
Hyunji Lee, Jun Kim, Junho Lee
doaj   +1 more source