Results 41 to 50 of about 9,152,726 (291)

The genome sequence of the Twenty-plume Moth, Alucita hexadactyla Linnaeus, 1758 [version 1; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research
We present a genome assembly from a specimen of Alucita hexadactyla (Twenty-plume Moth; Arthropoda; Insecta; Lepidoptera; Alucitidae). The genome sequence has a total length of 878.53 megabases.
David C. Lees, Caroline Eve Mitchell, Liam M. Crowley, Peter W. H. Holland   +3 more
doaj   +1 more source

FINISHING THE JOB - UTILITY OF LONG-READ SEQUENCING USING THE MINION FOR BACTERIAL GENOMICS [PDF]

, 2021
Sequencing technologies have evolved dramatically since the first two bacterial genomes were published. Currently, due to second generation sequencing, millions of bacterial genomic sequences exist, although a significantly smaller amount represent ...
Amada El-Sabeh, El-Sabeh, Amada
core   +1 more source

Long-read sequence and assembly of segmental duplications [PDF]

Nature Methods, 2018
We have developed a computational method based on polyploid phasing of long sequence reads to resolve collapsed regions of segmental duplications within genome assemblies. Segmental Duplication Assembler (SDA; https://github.com/mvollger/SDA ) constructs graphs in which paralogous sequence variants define the nodes and long-read sequences provide ...
Mitchell R. Vollger, Philip C. Dishuck, Melanie Sorensen, AnneMarie E. Welch, Vy Dang, Max L. Dougherty, Tina A. Graves-Lindsay, Richard K. Wilson, Mark J. P. Chaisson, Evan E. Eichler   +9 more
openaire   +2 more sources

Long-read sequencing of

JID Innovations
Loss-of-function (LOF) variants of the FLG gene are risk factors for atopic dermatitis. However, owing to the repetitive nature of exon 3, these variants are difficult to characterize.
Victor Grentzinger, Maria Artesi, Leonor Palmeira, Nathalie Renotte, Nadine Cambisano, Vinciane Dideberg, Laura Helou, Benoit Charloteaux, Bita Dezfoulian, Gilles Absil, Justine Pêtre, Murielle Sabatiello, Colombine Meunier, W.H. Irwin McLean, Aileen Sandilands, Maeve A. McAleer, Alan D. Irvine, Annette Uwineza, Alice Amani Uwajeni, Sabine Olivier, Keith Durkin, Vincent Bours   +21 more
doaj   +1 more source

Diagnostic capabilities of nanopore long‐read sequencing in muscular dystrophy

Annals of Clinical and Translational Neurology, 2022
Many individuals with muscular dystrophies remain genetically undiagnosed despite clinical diagnostic testing, including exome sequencing. Some may harbor previously undetected structural variants (SVs) or cryptic splice sites.
Christine C. Bruels, Hannah R. Littel, Audrey L. Daugherty, Seth Stafki, Elicia A. Estrella, Emily S. McGaughy, Don Truong, Jonathan P. Badalamenti, Lynn Pais, Vijay S. Ganesh, Anne O'Donnell‐Luria, Heather J. Stalker, Yang Wang, Christin Collins, Andrea Behlmann, Richard J. L. F. Lemmers, Silvère M. van derMaarel, Regina Laine, Partha S. Ghosh, Basil T. Darras, Carla D. Zingariello, Christina A. Pacak, Louis M. Kunkel, Peter B. Kang   +23 more
doaj   +1 more source

LongQC: A Quality Control Tool for Third Generation Sequencing Long Read Data [PDF]

, 2019
We propose LongQC as an easy and automated quality control tool for genomic datasets generated by third generation sequencing (TGS) technologies such as Oxford Nanopore technologies (ONT) and SMRT sequencing from Pacific Bioscience (PacBio).
Yoshinori Fukasawa, Carty, K., Luca Ermini, Ermini, Luca, Fukasawa, Yoshinori, Wang, H., Min-Sin Cheung, Karen Carty, Wang, Hai, Hai Wang, Cheung, M. -S., Cheung, Ming Sin, Fukasawa, Y., Ermini, L., Carty, Karen   +14 more
core   +2 more sources

Long-Read Sequencing for the Metagenomic Analysis of Microbiomes

BioTechniques, 2023
One technology, long-read sequencing, and one research field, microbiome studies, have risen to prominence over the last decade. But how can one be used in the other? What changes are being wrought? And what limitations remain? [Graphic: see text]
openaire   +2 more sources

Long-read sequence assembly of the gorilla genome [PDF]

Science, 2016
Improving on the gorilla genome Access to complete, high-quality genomes of nonhuman primates will also help us understand human biology. Gordon et al. used long-read sequencing technology to improve genome data on our close relative the gorilla.
Gordon, David, Huddleston, John, Chaisson, Mark JP, Hill, Christopher M, Kronenberg, Zev N, Munson, Katherine M, Malig, Maika, Raja, Archana, Fiddes, Ian, Hillier, LaDeana W, Dunn, Christopher, Baker, Carl, Armstrong, Joel, Diekhans, Mark, Paten, Benedict, Shendure, Jay, Wilson, Richard K, Haussler, David, Chin, Chen-Shan, Eichler, Evan E   +19 more
openaire   +4 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

JAFFAL: detecting fusion genes with long-read transcriptome sequencing

, 2022
In cancer, fusions are important diagnostic markers and targets for therapy. Long-read transcriptome sequencing allows the discovery of fusions with their full-length isoform structure.
Oshlack, A, Blombery, P, Davidson, NM, Sadras, T, Ekert, PG, Göke, J, Chen, Y, Ryland, GL, Jonathan Göke, Piers Blombery, Georgina L. Ryland, Nadia M. Davidson, Alicia Oshlack, Teresa Sadras, Ying Chen, Paul G. Ekert   +15 more
core   +1 more source