Results 171 to 180 of about 713,910 (249)

Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to <i>Sox2</i> looping with its distal enhancer. [PDF]

Genes Dev
Martinovic M, Flach KD, de Kort MAC, Maresca M, Teunissen H, Liu NQ, Lenstra TL, de Wit E.   +7 more
europepmc   +1 more source

High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL. [PDF]

J Biol Chem, 2023
Kaur P, Lu X, Xu Q, Irvin EM, Pappas C, Zhang H, Finkelstein IJ, Shi Z, Tao YJ, Yu H, Wang H.   +10 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Quantitative Visualization of Intracellular Nanometabolism Using Peak‐Shifted Dual‐State Emissive FRET Nanoprobes

Advanced Science, EarlyView.
This study reveals the long‐elusive intracellular dissolution mechanism of carrier‐free nanomedicines. By utilizing peak‐shifted dual‐state emissive FRET nanoprobes (PDFNPs) that undergo a distinct ratiometric fluorescence peak shift upon disassembly, we achieve real‐time, quantitative tracking of dissolution kinetics in live cells.
Farsai Taemaitree, Jinwoo Sung, Yutaro Miki, Ryuju Suzuki, Yoshitaka Koseki, Kunikazu Ishii, Minsang Kim, Keita Tanita, Kota Sato, Toru Nakazawa, Satoshi Katsube, Daisuke Unabara, Tasuku Hamaguchi, Keisuke Kawakami, Koji Yonekura, Akihide Hibara, Atsushi Wakamiya, Hiroshi Uji‐I, Hitoshi Kasai   +18 more
wiley   +1 more source

Polymer simulations guide the detection and quantification of chromatin loop extrusion by imaging. [PDF]

Nucleic Acids Res, 2023
Sabaté T, Lelandais B, Bertrand E, Zimmer C.   +3 more
europepmc   +1 more source

Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption. [PDF]

Mol Cell
Shah R, Tortora MMC, Louafi N, Rahmaninejad H, Hansen KL, Anderson EC, Bonitto K, Wen D, Giorgetti L, Fudenberg G, Nora EP.   +10 more
europepmc   +1 more source

Mechanically Reprogrammed Coaxial Fibers for Multiphysics Transduction and Human‐Machine Interfaces

Advanced Science, EarlyView.
A continuously wet‐spun coaxial fiber is developed to combine stretchable conductivity, resistive sensing, and self‐powered triboelectric sensing in a single architecture. A mechanically reprogrammed dual‐network sheath stabilizes large deformation and improves signal reliability. These fibers can be woven into textile interfaces for multichannel touch
Xinyi Cao, Chao Ye, Shengjie Ling, Ming Li, Zhao Sha, Chun‐Hui Wang, Shuhua Peng   +6 more
wiley   +1 more source

Uniform dynamics of cohesin-mediated loop extrusion in living human cells. [PDF]

Nat Genet
Sabaté T, Lelandais B, Robert MC, Szalay M, Tinevez JY, Bertrand E, Zimmer C.   +6 more
europepmc   +1 more source

Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III. [PDF]

PLoS Genet, 2023
Dinda M, Fine RD, Saha S, Wang Z, Zang C, Li M, Smith JS.   +6 more
europepmc   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source