The Smc complexes in DNA damage response [PDF]
Cell & Bioscience, 2012 The structural maintenance of chromosomes (Smc) proteins regulate nearly all aspects of chromosome biology and are critical for genomic stability. In eukaryotes, six Smc proteins form three heterodimers--Smc1/3, Smc2/4, and Smc5/6--which together with ...
Wu Nan, Yu Hongtao
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DNA-loop-extruding SMC complexes can traverse one another in vivo. [PDF]
Nat Struct Mol Biol, 2021 Chromosome organization mediated by structural maintenance of chromosomes (SMC) complexes is vital in many organisms. SMC complexes act as motors that extrude DNA loops, but it remains unclear what happens when multiple complexes encounter one another on
Brandão HB +4 more
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XerD unloads bacterial SMC complexes at the replication terminus. [PDF]
Mol Cell, 2021 SUMMARY Bacillus subtilis structural maintenance of chromosomes (SMC) complexes are topologically loaded at centromeric sites adjacent to the replication origin by the partitioning protein ParB.
Karaboja X +5 more
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Structural biology of SMC complexes across the tree of life.
Curr Opin Struct Biol, 2023 Structural maintenance of chromosomes (SMC) complexes guard and organize the three-dimensional structure of chromosomal DNA across the tree of life. Many SMC functions can be explained by an inherent motor activity that extrudes large DNA loops while the
Bürmann F, Löwe J.
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SMC complexes: Lifting the lid on loop extrusion. [PDF]
Curr Opin Cell Biol, 2022 Loop extrusion has emerged as a prominent hypothesis for how SMC complexes shape chromosomes – single molecule in vitro observations have yielded fascinating images of this process.
Higashi TL, Uhlmann F.
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Spontaneously directed loop extrusion in SMC complexes emerges from broken detailed balance and anisotropic DNA search. [PDF]
Nucleic Acids ResDNA loop formation by structural maintenance of chromosome (SMC) proteins, including cohesin, condensin, and the SMC5/6 complex, plays a pivotal role in genome organization.
Bonato A +5 more
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The SMC Hinge is a Selective Gate for Obstacle Bypass [PDF]
Nature CommunicationsDNA loop-extruding SMC complexes play vital roles in genome maintenance and DNA immunity. However, how these ring-shaped DNA motors navigate large DNA-bound obstacles has remained unclear.
Hon Wing Liu +5 more
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DNA tension-modulated translocation and loop extrusion by SMC complexes revealed by molecular dynamics simulations. [PDF]
Nucleic Acids Res, 2022 Structural Maintenance of Chromosomes (SMC) complexes play essential roles in genome organization across all domains of life. To determine how the activities of these large ( 50 nm) complexes are controlled by ATP binding and hydrolysis, we developed a ...
Nomidis SK +3 more
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Extensive mutual influences of SMC complexes shape 3D genome folding. [PDF]
NatureMammalian genomes are folded through the distinct actions of structural maintenance of chromosome (SMC) complexes, which include the chromatin loop-extruding cohesin (extrusive cohesin), the sister chromatid cohesive cohesin and the mitotic chromosome ...
Zhao H +15 more
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SMC complexes organize the bacterial chromosome by lengthwise compaction. [PDF]
Curr Genet, 2020 Structural maintenance of chromosomes (SMC) complexes are ancient and conserved molecular machines that organize chromosomes in all domains of life.
Mäkelä J, Sherratt D.
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