Results 31 to 40 of about 16,449 (234)
A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6
Scientific Reports, 2020 The SMC (Structural Maintenance of Chromosomes) complexes are composed of SMC dimers, kleisin and kleisin-interacting (HAWK or KITE) subunits. Mutual interactions of these subunits constitute the basal architecture of the SMC complexes.
Lucie Vondrova +5 more
doaj +1 more source
Positive Selection Drives the Evolution of the Structural Maintenance of Chromosomes (SMC) Complexes. [PDF]
Genes (Basel)Structural Maintenance of Chromosomes (SMC) complexes are an evolutionary conserved protein family. In most eukaryotes, three SMC complexes have been characterized, as follows: cohesin, condensin, and SMC5/6 complexes. These complexes are involved in a plethora of functions, and defects in SMC genes can lead to an increased risk of chromosomal ...
Forni D, Mozzi A, Sironi M, Cagliani R.
europepmc +3 more sources
Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic
Cell Reports, 2016 Structural maintenance of chromosomes (SMC) protein complexes, including cohesin and condensin, play key roles in the regulation of higher-order chromosome organization.
Jorine M. Eeftens +7 more
doaj +1 more source
Competitive binding of MatP and topoisomerase IV to the MukB hinge domain
eLife, 2021 Structural Maintenance of Chromosomes (SMC) complexes have ubiquitous roles in compacting DNA linearly, thereby promoting chromosome organization-segregation.
Gemma LM Fisher +10 more
doaj +1 more source
Structural Insights into Ring Formation of Cohesin and Related Smc Complexes. [PDF]
Trends Cell Biol, 2016 Cohesin facilitates sister chromatid cohesion through the formation of a large ring structure that encircles DNA. Its function relies on two structural maintenance of chromosomes (Smc) proteins, which are found in almost all organisms tested, from bacteria to humans.
Gligoris T, Löwe J.
europepmc +3 more sources
Open Chemistry, 2023 The intestinal microbial metabolite trimethylamine oxide (TMAO) affects the formation and development of atherosclerosis (AS). The design and development of an effective targeted drug to reduce serum TMAO levels may provide new avenues for inhibiting AS ...
Luo Jiaxin +3 more
doaj +1 more source
DNA sliding and loop formation by E. coli SMC complex: MukBEF
Biochemistry and Biophysics Reports, 2022 SMC (structural maintenance of chromosomes) complexes share conserved architectures and function in chromosome maintenance via an unknown mechanism. Here we have used single-molecule techniques to study MukBEF, the SMC complex in Escherichia coli.
Man Zhou
doaj +1 more source
Rings, bracelet or snaps: fashionable alternatives for Smc complexes [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2005 Abstract The mechanism of higher order chromosome organization has eluded researchers for over 100 years. A breakthrough occurred with the discovery of multi-subunit protein complexes that contain a core of two molecules from the structural maintenance of chromosome (Smc) family.
Catherine E, Huang +2 more
openaire +2 more sources
Distinct Activities of Bacterial Condensins for Chromosome Management in Pseudomonas aeruginosa
Cell Reports, 2020 Summary: Three types of structurally related structural maintenance of chromosomes (SMC) complexes, referred to as condensins, have been identified in bacteria.
Virginia S. Lioy +4 more
doaj +1 more source
SnapShot: SMC Protein Complexes Part II
Cell, 2016 This second of two SnapShots on SMC proteins depicts their roles at different stages of the eukaryotic cell cycle. The composition and architecture of SMC protein complexes and their regulators appear in SMC Protein Complexes Part I (available at http://www.cell.com/cell/pdf/S0092-8674%2815%2901690-6.pdf).
Haering, C., Gruber, S.
openaire +5 more sources