Results 31 to 40 of about 8,854,464 (148)

SMC Motor Proteins Extrude DNA Asymmetrically and Can Switch Directions

Cell
Structural maintenance of chromosomes (SMC) complexes organize the genome via DNA loop extrusion. Although some SMCs were reported to do so symmetrically, reeling DNA from both sides into the extruded DNA loop simultaneously, others perform loop ...
Cees Dekker, Stephan Gruber, Roman Barth
exaly   +2 more sources

SMC Complexes: From DNA to Chromosomes

Nature Reviews Molecular Cell Biology, 2016
Frank Uhlmann
exaly   +2 more sources

SMC complexes differentially compact mitotic chromosomes according to genomic context. [PDF]

Nat Cell Biol, 2017
Structural maintenance of chromosomes (SMC) protein complexes are key determinants of chromosome conformation. Using Hi-C and polymer modelling, we study how cohesin and condensin, two deeply conserved SMC complexes, organize chromosomes in the budding ...
Schalbetter SA, Goloborodko A, Fudenberg G, Belton JM, Miles C, Yu M, Dekker J, Mirny L, Baxter J.   +8 more
europepmc   +4 more sources

Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex [PDF]

, 2001
The structural maintenance of chromosomes (SMC) protein encoded by the fission yeast rad18 gene is involved in several DNA repair processes and has an essential function in DNA replication and mitotic control.
Moghraby, Jeelan S., Peter B Moens (16102748), Taylor, Elaine M., Lees, Jennifer H., Elaine M Taylor (16045169), Lehmann, Alan R., Jeelan S Moghraby (16102739), Alan Lehmann (4461370), Smit, Bep, Bep Smit (16102745), Moens, Peter B., Jennifer H Lees (16102742)   +11 more
core   +4 more sources

Repeated duplications and losses shaped SMC complex evolution from archaeal ancestors to modern eukaryotes

bioRxiv
Chromosome organization ensures accurate DNA replication, segregation, gene regulation and DNA damage repair. Across the tree of life, protein assemblages termed Structural Maintenance of Chromosomes (SMC) complexes determine chromosome organization ...
J. V. van Hooff, Maximilian W. D. Raas, E. Tromer, Laura Eme   +3 more
semanticscholar   +2 more sources

SMC complexes can traverse physical roadblocks bigger than their ring size

bioRxiv, 2021
The ring-shaped structural-maintenance-of-chromosomes (SMC) complexes condensin and cohesin extrude loops of DNA as a key motif in chromosome organization. It remains, how ever, unclear how these SMC motor proteins can extrude DNA loops in chromatin that
Biswajit Pradhan, R. Barth, Eugene Kim, I. Davidson, Benedikt W. Bauer, T. van Laar, Wayne Yang, Je-Kyung Ryu, J. van der Torre, J. Peters, C. Dekker   +10 more
semanticscholar   +1 more source

The loopy world of cohesin

eLife, 2021
DNA loops can be formed by a mechanism in which the cohesin complex pulls DNA strands through its ring structure using biased Brownian motion.
Kazuhiro Maeshima, Shiori Iida
doaj   +1 more source

Testing pseudotopological and nontopological models for SMC-driven DNA loop extrusion against roadblock-traversal experiments

Scientific Reports, 2023
DNA loop extrusion by structural-maintenance-of-chromosome (SMC) complexes has emerged as a primary organizing principle for chromosomes. The mechanism by which SMC motor proteins extrude DNA loops is still unresolved and much debated.
Roman Barth, Biswajit Pradhan, Eugene Kim, Iain F. Davidson, Jaco van der Torre, Jan-Michael Peters, Cees Dekker   +6 more
doaj   +1 more source

DYNAMIC PHYSICAL-GEOLOGICAL MODEL OF THE FIELD OF DIAMONDS FROM THE KOMSOMOLSKAYA KIMBERLITE PIPE (ALAKIT-MARKHA FIELD OF WESTERN YAKUTIA)

Геодинамика и тектонофизика, 2022
Petrophysical, tectonophysical and paleomagnetic studies were done on the field of diamonds from the Komsomolskaya kimberlite pipe to interpret the observed gravimagnetic field. As a result of studying the structural-material complexes (SMC) of the field,
K. M. Konstantinov, A. S. Gladkov
doaj   +1 more source

Chromosome organization by one-sided and two-sided loop extrusion

eLife, 2020
SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and progressively growing DNA loops.
Edward J Banigan, Aafke A van den Berg, Hugo B Brandão, John F Marko, Leonid A Mirny   +4 more
doaj   +1 more source