Results 51 to 60 of about 16,449 (234)

Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum

Nature Communications, 2020
The regulation of higher-order chromosome folding and segregation in bacteria is poorly understood. Here, Böhm et al. provide insights into the roles of DNA partitioning protein ParB and SMC condensin complexes in Corynebacterium glutamicum.
Kati Böhm, Giacomo Giacomelli, Andreas Schmidt, Axel Imhof, Romain Koszul, Martial Marbouty, Marc Bramkamp   +6 more
doaj   +1 more source

Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I. [PDF]

PLoS Genetics, 2013
The heteropentameric condensin complexes have been shown to participate in mitotic chromosome condensation and to be required for unperturbed chromatid segregation in nuclear divisions.
Sabine Herzog, Sonal Nagarkar Jaiswal, Evelin Urban, Anna Riemer, Sina Fischer, Stefan K Heidmann   +5 more
doaj   +1 more source

The SMC Condensin Complex Is Required for Origin Segregation in Bacillus subtilis [PDF]

Current Biology, 2014
SMC condensin complexes play a central role in organizing and compacting chromosomes in all domains of life [1, 2]. In the bacterium Bacillus subtilis, cells lacking SMC are viable only during slow growth and display decondensed chromosomes, suggesting that SMC complexes function throughout the genome [3, 4].
Wang, Xindan, Tang, Olive W., Riley, Eammon P., Rudner, David Z.   +3 more
openaire   +2 more sources

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

SMC translocation is unaffected by an excess of nucleoid associated proteins in vivo

Scientific Reports
Genome organization is important for DNA replication, gene expression, and chromosome segregation. In bacteria, two large families of proteins, nucleoid-associated proteins (NAPs) and SMC complexes, play important roles in organizing the genome. NAPs are
Zhongqing Ren, Lindsey E. Way, Xindan Wang   +2 more
doaj   +1 more source

Loop Extrusion Machinery Impairments in Models and Disease

Cells
Structural maintenance of chromosomes (SMC) complexes play a crucial role in organizing the three-dimensional structure of chromatin, facilitating key processes such as gene regulation, DNA repair, and chromosome segregation.
Anastasiya Ryzhkova, Ekaterina Maltseva, Nariman Battulin, Evelyn Kabirova   +3 more
doaj   +1 more source

Combing Chromosomal DNA Mediated by the SMC Complex: Structure and Mechanisms [PDF]

BioEssays, 2017
Genome maintenance requires various nucleoid‐associated factors in prokaryotes. Among them, the SMC (Structural Maintenance of Chromosomes) protein has been thought to play a static role in the organization and segregation of the chromosome during cell division.
Kamada, Katsuhiko, Barilla, Daniela
openaire   +4 more sources

Phase Field Failure Modeling: Brittle‐Ductile Dual‐Phase Microstructures under Compressive Loading

Advanced Engineering Materials, EarlyView.
The approach by Amor and the approach by Miehe and Zhang for asymmetric damage behavior in the phase field method for fracture are compared regarding their fitness for microcrack‐based failure modeling. The comparison is performed for the case of a dual‐phase microstructure with a brittle and a ductile constituent.
Jakob Huber, Jan Torgersen, Ewald Werner
wiley   +1 more source

Tissue‐Adhesive Fabric‐Based Bioelectronics for Wearable and Implantable Applications

Advanced Functional Materials, EarlyView.
An implantable and wearable bioelectronic textile (iTextile) is introduced as a unified platform bridging wearable and implantable systems. By integrating a self‐healing polymer, stretchable silk fabric, conductive composite electrodes, and an adhesive hydrogel, the platform enables conformal, stable interfacing with soft tissues. The iTextile supports
Soojung An, Yewon Kim, Kyoungryong Kim, Heewon Choi, Sungjun Yoon, Jaewon Ju, Mikyung Shin, Donghee Son   +7 more
wiley   +1 more source

Induced Phases of New H-bonded Supramolecular Liquid Crystal Complexes; Mesomorphic and Geometrical Estimation

Molecules, 2020
New five rings architecture of 1:1 supramolecular hydrogen bonded (H-bonded) complexes were formed between 4-(2-(pyridin-4-yl)diazenyl-3-methylphenyl 4-alkoxybenzoates and 4-n-alkoxyphenyliminobenzoic acids.
Rua B. Alnoman, Hoda A. Ahmed, Mohamed Hagar, Khulood A. Abu Al-Ola, Bedor Sh. Alrefay, Bashayer A. Haddad, Raghad F. Albalawi, Razan H. Aljuhani, Lama D. Aloqebi, Shoaa F. Alsenani   +9 more
doaj   +1 more source