Distinct Activities of Bacterial Condensins for Chromosome Management in Pseudomonas aeruginosa
Cell Reports, 2020 Summary: Three types of structurally related structural maintenance of chromosomes (SMC) complexes, referred to as condensins, have been identified in bacteria.
Virginia S. Lioy +4 more
doaj +1 more source
Open Chemistry, 2023 The intestinal microbial metabolite trimethylamine oxide (TMAO) affects the formation and development of atherosclerosis (AS). The design and development of an effective targeted drug to reduce serum TMAO levels may provide new avenues for inhibiting AS ...
Luo Jiaxin +3 more
doaj +1 more source
SMC Complexes Are Guarded by the SUMO Protease Ulp2 Against SUMO-Chain-Mediated Turnover
bioRxiv, 2020 Structural maintenance of chromosomes (SMC) complexes, cohesin, condensin and Smc5/6, are essential for viability and participate in multiple processes, including sister chromatid cohesion, chromosome condensation, and DNA repair.
Ivan Psakhye, Dana Branzei
semanticscholar +1 more source
Spo0J and SMC are required for normal chromosome segregation in Staphylococcus aureus
MicrobiologyOpen, 2020 Bacterial chromosome segregation is an essential cellular process that is particularly elusive in spherical bacteria such as the opportunistic human pathogen Staphylococcus aureus.
Helena Chan +2 more
doaj +1 more source
The bacterial chromosome: architecture and action of bacterial SMC and SMC-like complexes [PDF]
, 2014 Structural Maintenance of Chromosomes (SMC) protein complexes are found in all three domains of life. They are characterized by a distinctive and conserved architecture in which a globular ATPase 'head' domain is formed by the N- and C-terminal regions ...
Sherratt, David, Nolivos, Sophie
core +1 more source
Architecture of SMC-kleisin complexes [PDF]
, 2015 In all cellular systems, the transmission of bulk genetic information during proliferation occurs in the form of chromosomes. The segregation of these entities upon cell division is of pivotal importance for all forms of life.
Bürmann, F., Bürmann, Frank
core +1 more source
Dynamic assembly, localization and proteolysis of the
BMC Cell Biology, 2005 Background SMC proteins are key components of several protein complexes that perform vital tasks in different chromosome dynamics. Bacterial SMC forms a complex with ScpA and ScpB that is essential for chromosome arrangement and segregation.
Rinn Cornelia +5 more
doaj +1 more source
Structure-function relationships of SMC protein complexes for DNA loop extrusion
BIODESIGN, 2021 Structural Maintenance of Chromosome (SMC) complexes are vital for chromosome organization. They extrude DNA loops to compact 2 meters of DNA into a micrometer-sized chromosome structure.
Hansol Lee, H. Noh, Je-Kyung Ryu
semanticscholar +1 more source
Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling [PDF]
Open Biology, 2015 SMC proteins are essential components of three protein complexes that are important for chromosome structure and function. The cohesin complex holds replicated sister chromatids together, whereas the condensin complex has an essential role in mitotic ...
Helena Barysz +6 more
doaj +1 more source
The SAGA histone acetyltransferase module targets SMC5/6 to specific genes
Epigenetics & Chromatin, 2023 Background Structural Maintenance of Chromosomes (SMC) complexes are molecular machines driving chromatin organization at higher levels. In eukaryotes, three SMC complexes (cohesin, condensin and SMC5/6) play key roles in cohesion, condensation ...
L. Mahrik +9 more
doaj +1 more source