Results 71 to 80 of about 16,909 (206)

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

3D Printed Meter‐Scale Soft Origami Robots Capable of Load‐Bearing Actuation Via Crease Stiffness Modulation

Advanced Science, EarlyView.
Origami has inspired numerous soft deployable mechanisms for safe human‐robot interaction, while its intrinsic kinematic instability at arbitrary configurations limited their practical robotic application. This work presents a 3D printed meter‐scale origami robotic actuator capable of load‐bearing deformation through creaseline stiffness modulation.
Sung Yol Yu, Sang‐Joon Ahn, Wonchul Lee, Seunguk Moon, Hyun‐Jin Hong, Kyu‐Jin Cho   +5 more
wiley   +1 more source

Application and Single‐Cell Regulation Mechanism of Engineered EVs Combined With 4D‐Printed Hydrogel for Infected Burn Repair

Advanced Science, EarlyView.
4D bioprinted hydrogel loaded with FGF2‐modified extracellular vesicles (4D@F‐EVs) targets dermal fibroblasts and elevates local wound FGF2 levels via sustained release of F‐EVs. It activates PI3K‐Akt signaling, restores critical KGF+ fibroblast–KGFR+ keratinocyte crosstalk, enhances robust angiogenesis and collagen deposition to efficiently repair ...
Xiaomin Wang, Xiaoyan Li, Xiao Xu, Kelun Zhang, Fengjiao Yu, Zhen Shang, Nailong Pan, Junlin Lv, Yiwei Xu, Yan Tang, Liang Zhang, Xiaotong Li, Taoyi Wang, Jing Tao, Jiaxu Song, Mengyu Zhang, Xin Ma, Dan Han, Xiaoying Kong, Wenhua Xu   +19 more
wiley   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Chromosome Organization and Replisome Dynamics in Mycobacterium smegmatis

mBio, 2015
Subcellular organization of the bacterial nucleoid and spatiotemporal dynamics of DNA replication and segregation have been studied intensively, but the functional link between these processes remains poorly understood.
Isabella Santi, John D. McKinney
doaj   +1 more source

A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation

Advanced Science, EarlyView.
A CD14‐targeting in situ hydrogel formed from a microbial polysaccharide rapidly remodels the immune microenvironment by reprogramming macrophage polarization, suppressing excessive inflammation, and coordinating tissue regeneration. This multifunctional hydrogel promotes scar‐reduced wound repair through enhanced angiogenesis, collagen remodeling, and
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang   +5 more
wiley   +1 more source

Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structure

Nature Communications
In eukaryotes, structural maintenance of chromosomes (SMC) complexes form topologically associating domains (TADs) by extruding DNA loops and being stalled by roadblock proteins.
Kodai Yamaura, Naomichi Takemata, Masashi Kariya, Ayami Osaka, Sonoko Ishino, Masataka Yamauchi, Tomonori Tamura, Itaru Hamachi, Shoji Takada, Yoshizumi Ishino, Haruyuki Atomi   +10 more
doaj   +1 more source

Unveiling the Interfacial Dynamics of Crosslinked Biodegradable Polycaprolactone Solid Polymer Electrolytes and Li Metal During Lithium Plating and Stripping via Operando ATR‐FTIR Spectroscopy

Advanced Science, EarlyView.
This study presents a comprehensive interfacial characterization of the biodegradable PCL solid‐polymer electrolytes (SPEs) with Li metal, utilizing an advanced operando ATR‐FTIR spectroscopy. The investigation elucidates the interphase properties during Li plating/stripping in a zero‐excess cell configuration.
Jian‐Fen Wang, Matthias Weiling, Felix Pfeiffer, Marian C. Stan, Martin Winter, Masoud Baghernejad   +5 more
wiley   +1 more source

SMC complexes: Lifting the lid on loop extrusion. [PDF]

Curr Opin Cell Biol, 2022
Higashi TL, Uhlmann F.
europepmc   +1 more source

pyDMS: A Python package for the determination of physics‐informed dual‐mode sorption (DMS) parameters

AIChE Journal, EarlyView.
Abstract Sorption in glassy polymer membranes is commonly modeled with the dual‐mode sorption (DMS) model. Fitting the DMS model to sorption isotherms presents challenges, as multiple parameter sets may prove satisfactory. This work presents pyDMS, an open‐source Python package for the computation of DMS parameters obtained via a physics‐informed ...
Brandon C. Tapia, Pablo A. Dean, Jing Ying Yeo, Albert X. Wu, Zachary P. Smith   +4 more
wiley   +1 more source