Results 81 to 90 of about 8,854,464 (148)

Specialized interfaces of Smc5/6 control hinge stability and DNA association

Nature Communications, 2017
Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt, Hung Q. Dang, Owen S. Wells, Luis M. Polo, Matt A. Smith, Grant A. McGregor, Thomas Welte, Alan R. Lehmann, Laurence H. Pearl, Johanne M. Murray, Antony W. Oliver   +10 more
doaj   +1 more source

Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner

eLife, 2020
Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been proposed as a mechanism to organize chromatin in interphase and metaphase. However, the requirements for chromatin organization in these cell cycle phases are different, and
Stefan Golfier, Thomas Quail, Hiroshi Kimura, Jan Brugués   +3 more
doaj   +1 more source

Improving the treatment efficacy in horses against strongylatosis using supramolecular complexes of fenbendazole

Российский паразитологический журнал
The purpose of the research is to obtain solid dispersions (SD) of fenbendazole (FBZ) with polyvinylpyrrolidone (PVP), arabinogalactan (AG) or licorice extract (LE) using mechanochemical methods; to obtain the corresponding supramolecular complexes (SMC)
O. V. Demkina, M. S. Khalikov, S. S. Khalikov, A. I. Varlamova, T. T. Tursunov   +4 more
doaj   +1 more source

Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3

eLife, 2020
In addition to extruding DNA loops, cohesin entraps within its SMC-kleisin ring (S-K) individual DNAs during G1 and sister DNAs during S-phase. All three activities require related hook-shaped proteins called Scc2 and Scc3.
James E Collier, Byung-Gil Lee, Maurici Brunet Roig, Stanislav Yatskevich, Naomi J Petela, Jean Metson, Menelaos Voulgaris, Andres Gonzalez Llamazares, Jan Löwe, Kim A Nasmyth   +9 more
doaj   +1 more source

Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structure

Nature Communications
In eukaryotes, structural maintenance of chromosomes (SMC) complexes form topologically associating domains (TADs) by extruding DNA loops and being stalled by roadblock proteins.
Kodai Yamaura, Naomichi Takemata, Masashi Kariya, Ayami Osaka, Sonoko Ishino, Masataka Yamauchi, Tomonori Tamura, Itaru Hamachi, Shoji Takada, Yoshizumi Ishino, Haruyuki Atomi   +10 more
doaj   +1 more source

Chromosome Organization and Replisome Dynamics in Mycobacterium smegmatis

mBio, 2015
Subcellular organization of the bacterial nucleoid and spatiotemporal dynamics of DNA replication and segregation have been studied intensively, but the functional link between these processes remains poorly understood.
Isabella Santi, John D. McKinney
doaj   +1 more source

Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes

, 2015
SMC/kleisin complexes form elongated annular structures, which are critical for chromosome segregation, genome maintenance, and the regulation of gene expression.
Jan J. Palecek, Stephan Gruber, Palecek, J., Gruber, S.   +3 more
core   +1 more source

How Chromatin Motor Complexes Influence the Nuclear Architecture: A Review of Chromatin Organization, Cohesins, and Condensins with a Focus on C. elegans

DNA
Chromatin is the complex of DNA and associated proteins found in the nuclei of living organisms. How it is organized is a major research field as it has implications for replication, repair, and gene expression.
Bahaar Chawla, Györgyi Csankovszki
doaj   +1 more source

SMC complexes: from DNA to chromosomes

SMC (structural maintenance of chromosomes) complexes - which include condensin, cohesin and the SMC5-SMC6 complex - are major components of chromosomes in all living organisms, from bacteria to humans.
Frank Uhlmann (54006)
core   +1 more source

Cohesin positions the epigenetic reader Phf2 within the genome

The EMBO Journal
Genomic DNA is assembled into chromatin by histones, and extruded into loops by cohesin. These mechanisms control important genomic functions, but whether histones and cohesin cooperate in genome regulation is poorly understood.
Wen Tang, Lorenzo Costantino, Roman Stocsits, Gordana Wutz, Rene Ladurner, Otto Hudecz, Karl Mechtler, Jan-Michael Peters   +7 more
doaj   +1 more source