Results 81 to 90 of about 16,449 (234)

Miniaturized Magnetic Tip Design for Endoluminal Vine Robot Navigation

Advanced Robotics Research, EarlyView.
A magnetic tip mount is designed for a miniaturized 7 mm soft‐growing vine robot to enable wireless magnetic steering and onboard imaging, while preserving a 3 mm working channel. The internal–external ring magnets design balances magnetic attachment with low eversion pressure. Experiments demonstrate ±90° steering, 34 mm bending radius, and successful
Andrea Yanez Trujillo, Joshua Davy, James H. Chandler, James Avery, Pietro Valdastri   +4 more
wiley   +1 more source

Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner

eLife, 2020
Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been proposed as a mechanism to organize chromatin in interphase and metaphase. However, the requirements for chromatin organization in these cell cycle phases are different, and
Stefan Golfier, Thomas Quail, Hiroshi Kimura, Jan Brugués   +3 more
doaj   +1 more source

FiN‐Kiri: Fabric‐Based Inflatable Kirigami Actuator for Multimodal Soft Robots

Advanced Robotics Research, EarlyView.
This study introduces a type of inflatable fabric‐based kirigami actuator capable of performing bending motion. The actuator is utilized as soft grippers, a crawling robot and a swimming robot. The crawling robot demonstrated extraordinary motion capabilities, such as moving forward, turning and navigating a narrow tunnel.
Yang Yu, Yupei Zhang, Yanqi Yin, Yehui Wu, Jinyao Zhang, Ruiyu Bai, Jiaqiang Yao, Kewei Su, Chenyi Yu, Zhicheng Tian, Naipeng Li, Zhuang Zhang, Bo Li   +12 more
wiley   +1 more source

Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3

eLife, 2020
In addition to extruding DNA loops, cohesin entraps within its SMC-kleisin ring (S-K) individual DNAs during G1 and sister DNAs during S-phase. All three activities require related hook-shaped proteins called Scc2 and Scc3.
James E Collier, Byung-Gil Lee, Maurici Brunet Roig, Stanislav Yatskevich, Naomi J Petela, Jean Metson, Menelaos Voulgaris, Andres Gonzalez Llamazares, Jan Löwe, Kim A Nasmyth   +9 more
doaj   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

The interplay between asymmetric and symmetric DNA loop extrusion

eLife, 2020
Chromosome compaction is essential for reliable transmission of genetic information. Experiments suggest that ∼1000-fold compaction is driven by condensin complexes that extrude chromatin loops, by progressively collecting chromatin fiber from one or ...
Edward J Banigan, Leonid A Mirny
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Improving the treatment efficacy in horses against strongylatosis using supramolecular complexes of fenbendazole

Российский паразитологический журнал
The purpose of the research is to obtain solid dispersions (SD) of fenbendazole (FBZ) with polyvinylpyrrolidone (PVP), arabinogalactan (AG) or licorice extract (LE) using mechanochemical methods; to obtain the corresponding supramolecular complexes (SMC)
O. V. Demkina, M. S. Khalikov, S. S. Khalikov, A. I. Varlamova, T. T. Tursunov   +4 more
doaj   +1 more source

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions.

PLoS Genetics, 2013
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
Alice Copsey, Shangming Tang, Philip W Jordan, Hannah G Blitzblau, Sonya Newcombe, Andrew Chi-Ho Chan, Louise Newnham, Zhaobo Li, Stephen Gray, Alex D Herbert, Prakash Arumugam, Andreas Hochwagen, Neil Hunter, Eva Hoffmann   +13 more
doaj   +1 more source

Helix Alignment, Chevrons, and Edge Dislocations in Twist‐Bend Ferroelectric Nematics

Advanced Science, EarlyView.
The recently discovered twist‐bend ferroelectric nematic (NTBF) is the new member of the multiferroic family, representing a fluid with an oblique helicoidal (heliconical) periodic structure of spontaneous electric polarization. The work presents a thorough exploration of the material properties of this phase, how the periodic modulation of ...
Bijaya Basnet, Priyanka Kumari, Sathyanarayana Paladugu, Damian Pociecha, Jakub Karcz, Przemysław Kula, Nataša Vaupotič, Ewa Górecka, Oleg D Lavrentovich   +8 more
wiley   +1 more source