Results 81 to 90 of about 16,909 (206)

DNA-loop-extruding SMC complexes can traverse one another in vivo. [PDF]

Nat Struct Mol Biol, 2021
Brandão HB, Ren Z, Karaboja X, Mirny LA, Wang X.   +4 more
europepmc   +1 more source

Robust Reinforcement Learning Control Framework for a Quadrotor Unmanned Aerial Vehicle Using Critic Neural Network

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Quadrotor unmanned aerial vehicle control is critical to maintain flight safety and efficiency, especially when facing external disturbances and model uncertainties. This article presents a robust reinforcement learning control scheme to deal with these challenges.
Yu Cai, Yefeng Yang, Tao Huang, Boyang Li   +3 more
wiley   +1 more source

DNA tension-modulated translocation and loop extrusion by SMC complexes revealed by molecular dynamics simulations. [PDF]

Nucleic Acids Res, 2022
Nomidis SK, Carlon E, Gruber S, Marko JF.   +3 more
europepmc   +1 more source

Digital Twins for the Design, Interactive Control, and Deployment of Modular, Fiber‐Reinforced Soft Continuum Arms

Advanced Intelligent Systems, EarlyView.
A digital twin framework is presented for modular soft continuum arms built from fiber‐reinforced pneumatic actuators. Cosserat rod models describe individual actuators, while virtual assemblies are formed through serial and parallel networks, preserving actuator‐level architecture and arm deformation.
Seung Hyun Kim, Jiamiao Guo, Arman Tekinalp, Heng‐Sheng Chang, Ugur Akcal, Tixian Wang, Darren Biskup, Benjamin Walt, Girish Chowdhary, Girish Krishnan, Prashant G. Mehta, Mattia Gazzola   +11 more
wiley   +1 more source

Development of an Inchworm‐Like Dual‐Balloon‐Assisted Colonoscopic Robot Based on a Two‐Segment Extensible Continuum Section

Advanced Intelligent Systems, EarlyView.
This work presents an inchworm‐like dual‐balloon‐assisted colonoscopic robot (IDCR) based on a rod‐driven two‐segment continuum section. The IDCR enables the active straightening of the sigmoid colon through an inchworm‐like locomotion strategy, thereby avoiding loop formation.
Dezhi Song, Bohan Leng, Yi Liu, Xiangyang Yu, Chaoyang Shi   +4 more
wiley   +1 more source

A Multistage Venturi Amplifier for Rapid Inflation of Soft Robots

Advanced Intelligent Systems, EarlyView.
This work presents the amplifier inflator for soft robotic systems (AIRS), a compact, lightweight, and effective device for rapidly deploying inflatable structures to high pressure. By integrating a check valve with a Venturi‐based air entrainer, AIRS delivers an initial high‐flow output followed by pressurization, supporting fast inflation and ...
Saba Firouznia, Ciqun Xu, Tim Helps, Majid Taghavi, Jonathan Rossiter   +4 more
wiley   +1 more source

How Chromatin Motor Complexes Influence the Nuclear Architecture: A Review of Chromatin Organization, Cohesins, and Condensins with a Focus on C. elegans

DNA
Chromatin is the complex of DNA and associated proteins found in the nuclei of living organisms. How it is organized is a major research field as it has implications for replication, repair, and gene expression.
Bahaar Chawla, Györgyi Csankovszki
doaj   +1 more source

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

Utilization of immune checkpoint inhibitors for the treatment of cancer in Scotland, 2018–2024: A national retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of the study is to describe the use of immune checkpoint inhibitors (ICIs) for the treatment of cancer in Scotland. Methods The retrospective observational cohort study included patients aged 18 years or older who commenced treatment with an ICI in Scotland between 1 January 2018 and 31 December 2024.
Tanja Mueller, Christine Crearie, Liya Lu, Jiafeng Pan, Fraser N. Sneden, David Martin, Amanj Kurdi, Catherine S. Thomson, Julie Clarke, Marion Bennie   +9 more
wiley   +1 more source