Results 101 to 110 of about 16,449 (234)

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Formation of Light‐Emitting Defects in Ag‐Based Memristors

Advanced Electronic Materials, EarlyView.
How does a memristor begin to emit light‐before it even conducts? This work reveals that nanoscale silver clusters form, diffuse, and aggregate during activation, driving early photoluminescence ahead of current flow. Linking these precursor dynamics to later electroluminescence, it uncovers the origins of light emission and enables precise control of ...
Diana Singh, Maciej Ćwierzona, Régis Parvaud, Sebastian Maćkowski, Alexandre Bouhelier   +4 more
wiley   +1 more source

Accelerated Oxygen Evolution Kinetics in Layered Double Perovskites via Hydroxide Surface Engineering for Anion Exchange Membrane Water Electrolysis

Advanced Energy Materials, EarlyView.
Our work showcases an innovative approach to address fundamental challenge in AEMWE system by constructing NiFe(OH)x/PBSCF heterostructure via scalable and conformal surface engineering process. Electrical conductivity gradient in the heterostructure increases the OER kinetics by promoting charge transfer, while balancing cation dissolution and re ...
Ki‐Yong Yoon, Hyunmin Kim, Kyung‐Bok Lee, Jaehoon Jeong, Dohyung Kim, Hee Yoon Roh, Ji‐Hoon Lee, Rong Ma, Yunfei Bu, Sung Mook Choi, Hosik Lee, Jihwan An, Juchan Yang   +12 more
wiley   +1 more source

How Chromatin Motor Complexes Influence the Nuclear Architecture: A Review of Chromatin Organization, Cohesins, and Condensins with a Focus on C. elegans

DNA
Chromatin is the complex of DNA and associated proteins found in the nuclei of living organisms. How it is organized is a major research field as it has implications for replication, repair, and gene expression.
Bahaar Chawla, Györgyi Csankovszki
doaj   +1 more source

Robust Reinforcement Learning Control Framework for a Quadrotor Unmanned Aerial Vehicle Using Critic Neural Network

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Quadrotor unmanned aerial vehicle control is critical to maintain flight safety and efficiency, especially when facing external disturbances and model uncertainties. This article presents a robust reinforcement learning control scheme to deal with these challenges.
Yu Cai, Yefeng Yang, Tao Huang, Boyang Li   +3 more
wiley   +1 more source

Digital Twins for the Design, Interactive Control, and Deployment of Modular, Fiber‐Reinforced Soft Continuum Arms

Advanced Intelligent Systems, EarlyView.
A digital twin framework is presented for modular soft continuum arms built from fiber‐reinforced pneumatic actuators. Cosserat rod models describe individual actuators, while virtual assemblies are formed through serial and parallel networks, preserving actuator‐level architecture and arm deformation.
Seung Hyun Kim, Jiamiao Guo, Arman Tekinalp, Heng‐Sheng Chang, Ugur Akcal, Tixian Wang, Darren Biskup, Benjamin Walt, Girish Chowdhary, Girish Krishnan, Prashant G. Mehta, Mattia Gazzola   +11 more
wiley   +1 more source

Utilization of immune checkpoint inhibitors for the treatment of cancer in Scotland, 2018–2024: A national retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of the study is to describe the use of immune checkpoint inhibitors (ICIs) for the treatment of cancer in Scotland. Methods The retrospective observational cohort study included patients aged 18 years or older who commenced treatment with an ICI in Scotland between 1 January 2018 and 31 December 2024.
Tanja Mueller, Christine Crearie, Liya Lu, Jiafeng Pan, Fraser N. Sneden, David Martin, Amanj Kurdi, Catherine S. Thomson, Julie Clarke, Marion Bennie   +9 more
wiley   +1 more source

Migrant success in UK Education: Are there lessons for government social mobility policy?

British Educational Research Journal, EarlyView.
Abstract The school achievement and career aspirations of 23 sixth form students at a multi‐cultural urban academy in the UK are explored through interviews. The sample includes 16 s‐generation migrants, 6 UK‐born students with migrant parents and 1 UK‐born student, selected to represent a cohort of over 300 post‐16 learners.
Bernard Barker, Kate Hoskins
wiley   +1 more source

On the complexity of standard and waste-free SMC samplers

35 pages, 2 ...
Fay, Yvann Le, Chopin, Nicolas, Vihola, Matti   +2 more
openaire   +2 more sources