Results 61 to 70 of about 16,449 (234)

RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes

Life Science Alliance, 2021
Using both experiments and mathematical modelling, the authors show that RNA polymerase backtracking contributes to the accumulation of condensin in the termination zone of active genes.
Julieta Rivosecchi, Daniel Jost, Laetitia Vachez, François DR Gautier, Pascal Bernard, Vincent Vanoosthuyse   +5 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Structural insights into DNA loop extrusion by SMC protein complexes

Current Opinion in Structural Biology, 2020
Structural Maintenance of Chromosomes (SMC) protein complexes play key roles in the three-dimensional organization of genomes in all kingdoms of life. Recent insights from chromosome contact mapping experiments and single-molecule imaging assays suggest that these complexes achieve distinct cellular functions by extruding large loops of DNA while they ...
Datta, Sumanjit, Lecomte, Léa, Haering, Christian H   +2 more
openaire   +3 more sources

Biomimetic Vascular Scaffold with Seamless Electrospun Aligned Nanofiber Conduit and 3D‐Printed Coil Reinforcement

Advanced Healthcare Materials, EarlyView.
We introduce a new fabrication method that overcomes the current limitation of tubular gap electrospinning. We successfully fabricated a seamless hollow tube with fibers aligned along the longitudinal axis in diameters as small as 300 µm, and then reinforced it using 4‐axis 3D printing.
Seyed Aliakbar Hosseini Toopghara, Young‐Ook Hwang, In A Kim, Che‐I Hyun, Hochung Ryu, Won‐Jae Kim, Jeong‐Tae Koh, Hyun‐Pil Lim, Jin‐Ho Kang, Sang‐Won Park   +9 more
wiley   +1 more source

Architecture of SMC-kleisin complexes

, 2015
Die universellen Träger genetischer Information bei der Vermehrung zellulären Lebens sind die Chromosomen. Die Segregation dieser Einheiten während der Zellteilung ist für alle Organismen unabdingbar. Structural Maintenance of Chromosomes (SMC)-Kleisin-Komplexe sind universelle und essentielle Faktoren, welche die korrekte Organisation und Segregation ...
openaire   +2 more sources

Artificial Intelligence‐Assisted Workflow for Transmission Electron Microscopy: From Data Analysis Automation to Materials Knowledge Unveiling

Advanced Materials, EarlyView.
AI‐Assisted Workflow for (Scanning) Transmission Electron Microscopy: From Data Analysis Automation to Materials Knowledge Unveiling. Abstract (Scanning) transmission electron microscopy ((S)TEM) has significantly advanced materials science but faces challenges in correlating precise atomic structure information with the functional properties of ...
Marc Botifoll, Ivan Pinto‐Huguet, Enzo Rotunno, Thomas Galvani, Catalina Coll, Payam Habibzadeh Kavkani, Maria Chiara Spadaro, Yann‐Michel Niquet, Martin Børstad Eriksen, Sara Martí‐Sánchez, Georgios Katsaros, Giordano Scappucci, Peter Krogstrup, Giovanni Isella, Andreu Cabot, Gonzalo Merino, Pablo Ordejón, Stephan Roche, Vincenzo Grillo, Jordi Arbiol   +19 more
wiley   +1 more source

Electrically Tunable Heliconical Smectic Superstructure in Polar Fluids

Advanced Materials, EarlyView.
Strong dipole–dipole interactions give rise to an emergent polar smectic phase with spontaneous chiral symmetry breaking. This resulting polar heliconical smectic superstructure enables novel functionalities in polar fluids, such as color modulation driven by electric field strength and frequency, as well as second‐harmonic generation amplification ...
Hiroya Nishikawa, Dennis Kwaria, Atsuko Nihonyanagi, Koki Sano, Hiroyuki Yoshida, Fumito Araoka   +5 more
wiley   +1 more source

TGFβ1-induced Baf60c regulates both smooth muscle cell commitment and quiescence.

PLoS ONE, 2012
Smooth muscle cells (SMCs) play critical roles in a number of diseases; however, the molecular mechanism underlying their development is unclear. Although the role of TGFβ1 signaling in SMC development is well established, the downstream molecular ...
Abhishek Sohni, Francesca Mulas, Fulvia Ferrazzi, Aernout Luttun, Riccardo Bellazzi, Danny Huylebroeck, Stephen C Ekker, Catherine M Verfaillie   +7 more
doaj   +1 more source

Genetic interaction of the SMC complex with topoisomerase IV in Bacillus subtilis [PDF]

Microbiology, 2005
The role of topoisomerase IV (Topo IV) and of the structural maintenance of chromosomes (SMC) complex in chromosome compaction and in global protein synthesis was investigated. Lowering of the levels of Topo IV led to chromosome decondensation, while overproduction induced chromosome hyper-compaction, showing that Topo IV has an influence on the ...
Serkalem, Tadesse, Judita, Mascarenhas, Bernd, Kösters, Andrej, Hasilik, Peter L, Graumann   +4 more
openaire   +3 more sources

Two‐Way Shape Memory Polymer Composite Gripper for Adaptive Robotic Applications

Advanced Materials Technologies, EarlyView.
A two‐way shape memory polymer (SMP) composite is developed with intrinsic shape‐changing capability driven solely by temperature, eliminating external actuation loads. Embedding the SMP in a low‐stiffness elastomeric matrix enabled reversible transformations during heating and cooling cycles.
Aamna Hameed, Kamran Ahmed Khan
wiley   +1 more source