Results 61 to 70 of about 8,854,464 (148)

Replisomes restrict SMC translocation in vivo

Nature Communications
Structural maintenance of chromosomes (SMC) complexes organize genomes by extruding DNA loops, while replisomes duplicate entire chromosomes. These essential molecular machines must collide frequently in every cell cycle, yet how such collisions are ...
Qin Liao, Hugo B. Brandão, Zhongqing Ren, Xindan Wang   +3 more
doaj   +1 more source

Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm. [PDF]

PLoS ONE, 2014
In abdominal aortic aneurysm (AAA), macrophages are detected in the proximity of aortic smooth muscle cells (SMCs). We have previously demonstrated in a murine model of AAA that apoptotic SMCs attract monocytes and other leukocytes by producing MCP-1 ...
Qiwei Wang, Jun Ren, Stephanie Morgan, Zhenjie Liu, Changlin Dou, Bo Liu   +5 more
doaj   +1 more source

Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum

Nature Communications, 2020
The regulation of higher-order chromosome folding and segregation in bacteria is poorly understood. Here, Böhm et al. provide insights into the roles of DNA partitioning protein ParB and SMC condensin complexes in Corynebacterium glutamicum.
Kati Böhm, Giacomo Giacomelli, Andreas Schmidt, Axel Imhof, Romain Koszul, Martial Marbouty, Marc Bramkamp   +6 more
doaj   +1 more source

SMC translocation is unaffected by an excess of nucleoid associated proteins in vivo

Scientific Reports
Genome organization is important for DNA replication, gene expression, and chromosome segregation. In bacteria, two large families of proteins, nucleoid-associated proteins (NAPs) and SMC complexes, play important roles in organizing the genome. NAPs are
Zhongqing Ren, Lindsey E. Way, Xindan Wang   +2 more
doaj   +1 more source

Loop Extrusion Machinery Impairments in Models and Disease

Cells
Structural maintenance of chromosomes (SMC) complexes play a crucial role in organizing the three-dimensional structure of chromatin, facilitating key processes such as gene regulation, DNA repair, and chromosome segregation.
Anastasiya Ryzhkova, Ekaterina Maltseva, Nariman Battulin, Evelyn Kabirova   +3 more
doaj   +1 more source

Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I. [PDF]

PLoS Genetics, 2013
The heteropentameric condensin complexes have been shown to participate in mitotic chromosome condensation and to be required for unperturbed chromatid segregation in nuclear divisions.
Sabine Herzog, Sonal Nagarkar Jaiswal, Evelin Urban, Anna Riemer, Sina Fischer, Stefan K Heidmann   +5 more
doaj   +1 more source

Induced Phases of New H-bonded Supramolecular Liquid Crystal Complexes; Mesomorphic and Geometrical Estimation

Molecules, 2020
New five rings architecture of 1:1 supramolecular hydrogen bonded (H-bonded) complexes were formed between 4-(2-(pyridin-4-yl)diazenyl-3-methylphenyl 4-alkoxybenzoates and 4-n-alkoxyphenyliminobenzoic acids.
Rua B. Alnoman, Hoda A. Ahmed, Mohamed Hagar, Khulood A. Abu Al-Ola, Bedor Sh. Alrefay, Bashayer A. Haddad, Raghad F. Albalawi, Razan H. Aljuhani, Lama D. Aloqebi, Shoaa F. Alsenani   +9 more
doaj   +1 more source

RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genes

Life Science Alliance, 2021
Using both experiments and mathematical modelling, the authors show that RNA polymerase backtracking contributes to the accumulation of condensin in the termination zone of active genes.
Julieta Rivosecchi, Daniel Jost, Laetitia Vachez, François DR Gautier, Pascal Bernard, Vincent Vanoosthuyse   +5 more
doaj   +1 more source

Microinjection Techniques in Fly Embryos to Study the Function and Dynamics of SMC Complexes.

Methods in molecular biology, 2019
Structural maintenance of chromosomes (SMC) proteins are critical to maintain mitotic fidelity in all organisms. Over the last decades, acute inactivation of these complexes, together with the analysis of their dynamic binding to mitotic chromatin, has ...
Catarina Carmo, Margarida Araújo, Raquel A. Oliveira   +2 more
semanticscholar   +1 more source

Are SMC Complexes Loop Extruding Factors? Linking Theory With Fact

Bioessays, 2018
The extreme length of chromosomal DNA requires organizing mechanisms to both promote functional genetic interactions and ensure faithful chromosome segregation when cells divide.
J. Baxter, Antony W. Oliver, S. Schalbetter   +2 more
semanticscholar   +1 more source