Results 41 to 50 of about 16,449 (234)

Spo0J and SMC are required for normal chromosome segregation in Staphylococcus aureus

MicrobiologyOpen, 2020
Bacterial chromosome segregation is an essential cellular process that is particularly elusive in spherical bacteria such as the opportunistic human pathogen Staphylococcus aureus.
Helena Chan, Bill Söderström, Ulf Skoglund   +2 more
doaj   +1 more source

Molecular Architecture of SMC Proteins and the Yeast Cohesin Complex [PDF]

Molecular Cell, 2002
Sister chromatids are held together by the multisubunit cohesin complex, which contains two SMC (Smc1 and Smc3) and two non-SMC (Scc1 and Scc3) proteins. The crystal structure of a bacterial SMC "hinge" region along with EM studies and biochemical experiments on yeast Smc1 and Smc3 proteins show that SMC protamers fold up individually into rod-shaped ...
Haering, Christian H., Löwe, Jan, Hochwagen, Andreas, Nasmyth, Kim   +3 more
openaire   +2 more sources

Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling [PDF]

Open Biology, 2015
SMC proteins are essential components of three protein complexes that are important for chromosome structure and function. The cohesin complex holds replicated sister chromatids together, whereas the condensin complex has an essential role in mitotic ...
Helena Barysz, Ji Hun Kim, Zhuo Angel Chen, Damien F. Hudson, Juri Rappsilber, Dietlind L. Gerloff, William C. Earnshaw   +6 more
doaj   +1 more source

Are SMC Complexes Loop Extruding Factors? Linking Theory With Fact [PDF]

BioEssays, 2018
The extreme length of chromosomal DNA requires organizing mechanisms to both promote functional genetic interactions and ensure faithful chromosome segregation when cells divide. Microscopy and genome‐wide contact frequency analyses indicate that intra‐chromosomal looping of DNA is a primary pathway of chromosomal organization during all stages of the ...
Baxter, Jonathan, Oliver, Antony W, Schalbetter, Stephanie A   +2 more
openaire   +2 more sources

The SAGA histone acetyltransferase module targets SMC5/6 to specific genes

Epigenetics & Chromatin, 2023
Background Structural Maintenance of Chromosomes (SMC) complexes are molecular machines driving chromatin organization at higher levels. In eukaryotes, three SMC complexes (cohesin, condensin and SMC5/6) play key roles in cohesion, condensation ...
L. Mahrik, B. Stefanovie, A. Maresova, J. Princova, P. Kolesar, E. Lelkes, C. Faux, D. Helmlinger, M. Prevorovsky, J. J. Palecek   +9 more
doaj   +1 more source

Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm. [PDF]

PLoS ONE, 2014
In abdominal aortic aneurysm (AAA), macrophages are detected in the proximity of aortic smooth muscle cells (SMCs). We have previously demonstrated in a murine model of AAA that apoptotic SMCs attract monocytes and other leukocytes by producing MCP-1 ...
Qiwei Wang, Jun Ren, Stephanie Morgan, Zhenjie Liu, Changlin Dou, Bo Liu   +5 more
doaj   +1 more source

Interactions Between the SMC-Complex, Spo0J and DNA [PDF]

Biophysical Journal, 2014
In bacteria the length of DNA found within the cell vastly exceeds the length of the cell itself. To overcome this problem bacteria compact their DNA into structures called nucleoids. Although how nucleoids are organised remains poorly understood several different classes of protein have been implicated in their formation, including the Structural ...
Taylor, James A., Gwynn, Emma, Pastrana, Cesar, Moreno Herrero, Fernando, Dillingham, Mark S.   +4 more
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source