Parallel evolution of X chromosome-specific SMC complexes in two nematode lineages
bioRxivMechanisms of X chromosome dosage compensation have been studied extensively in three model organisms that represent distinct clades. The diversity within each clade as a function of sex chromosome evolution though is largely unknown.
Aharonoff A +3 more
europepmc +2 more sources
An SMC-like protein binds and regulates Caenorhabditis elegans condensins. [PDF]
PLoS Genetics, 2017 Structural Maintenance of Chromosomes (SMC) family proteins participate in multisubunit complexes that govern chromosome structure and dynamics.
Lucy Fang-I Chao +4 more
doaj +3 more sources
Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes. [PDF]
Mol Cell Proteomics, 2016 Packaging of DNA into condensed chromosomes during mitosis is essential for the faithful segregation of the genome into daughter nuclei. Although the structure and composition of mitotic chromosomes have been studied for over 30 years, these aspects are ...
Ohta S +10 more
europepmc +2 more sources
Bridging-induced phase separation induced by cohesin SMC protein complexes [PDF]
Science Advances, 2021 Yeast cohesin complexes cluster onto long DNA into liquid droplets, which they accomplish by ATP-independent DNA bridging. Structural maintenance of chromosome (SMC) protein complexes are able to extrude DNA loops.
Je-Kyung Ryu +11 more
semanticscholar +3 more sources
SMC complex unidirectionally translocates DNA by coupling segment capture with an asymmetric kleisin path [PDF]
eLifeSMC (structural maintenance of chromosomes) protein complexes are ring-shaped molecular motors essential for genome folding. Despite recent progress, the detailed molecular mechanism of DNA translocation in concert with the ATP-driven conformational ...
Masataka Yamauchi +3 more
doaj +2 more sources
Single-domain antibody inhibitors target the coiled coil arms of the Bacillus subtilis SMC complex [PDF]
eLifeSynthetic nanobodies—also called sybodies—have proven valuable for stabilizing conformations of purified proteins, advancing structural and functional studies for example of transmembrane proteins. However, their utility in modulating protein function in
Ophélie J Gosselin +4 more
doaj +2 more sources
Submolecular video-imaging of the Smc5/6 complex topologically bound to DNA [PDF]
Nature CommunicationsStructural maintenance of chromosomes (SMC) complexes, including cohesin and condensin, are ring-shaped ATPases that organize chromosome architecture by holding DNA segments together.
Kenichi Umeda +3 more
doaj +2 more sources
Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. [PDF]
PLoS Genetics, 2013 During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
Alice Copsey +13 more
doaj +2 more sources
DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes [PDF]
bioRxiv, 2018 Cells possess remarkable control of the folding and entanglement topology of long and flexible chromosomal DNA molecules. It is thought that structural maintenance of chromosome (SMC) protein complexes play a crucial role in this, by organizing long DNAs
J. Marko +3 more
semanticscholar +3 more sources
Evolutionary Patterns of the Genes Involved in the Integrity and Segregation of Chromosomes in Sawflies (Hymenoptera: Symphyta) [PDF]
Ecology and EvolutionThe genes involved in the regulation of the meiotic process act important roles in maintaining the structural integrity of chromosomes, ensuring accurate mitotic segregation, and preserving genome stability.
Ayşe Rümeysa Nalça +1 more
doaj +2 more sources