Evidence for binary Smc complexes lacking kite subunits in archaea [PDF]
IUCrJ, 2020 SMC complexes play a central role in chromosome organization in all domains of life. The bacterial Smc–ScpAB complex is a three-subunit complex composed of Smc, ScpA and ScpB.
Jae-Hyun Jeon +6 more
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Positive Selection Drives the Evolution of the Structural Maintenance of Chromosomes (SMC) Complexes. [PDF]
Genes (Basel)Structural Maintenance of Chromosomes (SMC) complexes are an evolutionary conserved protein family. In most eukaryotes, three SMC complexes have been characterized, as follows: cohesin, condensin, and SMC5/6 complexes.
Forni D, Mozzi A, Sironi M, Cagliani R.
europepmc +3 more sources
SMC complexes link gene expression and genome architecture. [PDF]
Curr Opin Genet Dev, 2014 The Structural Maintenance of Chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure.
Dowen JM, Young RA.
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Organization of Chromosomal DNA by SMC Complexes
Annual Review of Genetics, 2019 Structural maintenance of chromosomes (SMC) complexes are key organizers of chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such as chromosome segregation, chromosome maintenance, sister chromatid cohesion, and ...
James Rhodes +2 more
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SMC modulates ParB engagement in segregation complexes in streptomyces [PDF]
Nature CommunicationsParB is a bacterial chromosome segregation protein with recently demonstrated CTPase activity. CTP-bound ParB homodimers are loaded onto DNA at parS sites and spread along DNA, forming a large nucleoprotein complex.
Katarzyna Pawlikiewicz +5 more
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Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus. [PDF]
Science, 2017 Structural maintenance of chromosomes (SMC) complexes play critical roles in chromosome dynamics in virtually all organisms, but how they function remains poorly understood.
Wang X +4 more
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Looping the Genome with SMC Complexes. [PDF]
Annual Review of Biochemistry, 2023 SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily conserved family of motor proteins that hold sister chromatids together and fold genomes throughout the cell cycle by DNA loop extrusion.
Eugene Kim, R. Barth, C. Dekker
semanticscholar +2 more sources
SMC complexes orchestrate the mitotic chromatin interaction landscape. [PDF]
Curr Genet, 2018 Chromatin is a very long DNA–protein complex that controls the expression and inheritance of the genetic information. Chromatin is stored within the nucleus in interphase and further compacted into chromosomes during mitosis.
Kakui Y, Uhlmann F.
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A low Smc flux avoids collisions and facilitates chromosome organization in Bacillus subtilis
eLife, 2021 SMC complexes are widely conserved ATP-powered DNA-loop-extrusion motors indispensable for organizing and faithfully segregating chromosomes. How SMC complexes translocate along DNA for loop extrusion and what happens when two complexes meet on the same ...
Anna Anchimiuk +5 more
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Structural Insights into Ring Formation of Cohesin and Related Smc Complexes.
Trends Cell Biol, 2016 Cohesin facilitates sister chromatid cohesion through the formation of a large ring structure that encircles DNA. Its function relies on two structural maintenance of chromosomes (Smc) proteins, which are found in almost all organisms tested, from ...
Gligoris T, Löwe J.
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