Results 11 to 20 of about 16,449 (234)
SMC complexes organize the bacterial chromosome by lengthwise compaction [PDF]
Current Genetics, 2020 AbstractStructural maintenance of chromosomes (SMC) complexes are ancient and conserved molecular machines that organize chromosomes in all domains of life. We propose that the principles of chromosome folding needed to accommodate DNA inside a cell in an accessible form will follow similar principles in prokaryotes and eukaryotes.
David Sherratt, Jarno Mäkelä
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Dynamic assembly, localization and proteolysis of the
BMC Cell Biology, 2005 Background SMC proteins are key components of several protein complexes that perform vital tasks in different chromosome dynamics. Bacterial SMC forms a complex with ScpA and ScpB that is essential for chromosome arrangement and segregation.
Rinn Cornelia +5 more
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SMC complexes: Lifting the lid on loop extrusion. [PDF]
Curr Opin Cell Biol, 2022 Loop extrusion has emerged as a prominent hypothesis for how SMC complexes shape chromosomes - single molecule in vitro observations have yielded fascinating images of this process. When not extruding loops, SMC complexes are known to topologically entrap one or more DNAs. Here, we review how structural insight into the SMC complex cohesin has led to a
Higashi TL, Uhlmann F.
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DNA tension-modulated translocation and loop extrusion by SMC complexes revealed by molecular dynamics simulations [PDF]
Nucleic Acids Research, 2022 Enrico Carlon +2 more
exaly +2 more sources
A phospho-switch to trigger mitotic chromosome condensation [PDF]
Biology DirectOne of the most eye-catching events in cell biology is the condensation of chromosomes. During mitosis, the diffuse interphase chromatin rearranges into compact, rod-shaped chromosomes that can be precisely segregated between the daughter cells.
Alessandro Borsellini
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Looping the Genome with SMC Complexes
Annual Review of Biochemistry, 2023 SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily conserved family of motor proteins that hold sister chromatids together and fold genomes throughout the cell cycle by DNA loop extrusion. These complexes play a key role in a variety of functions in the packaging and regulation of chromosomes, and they have been ...
Kim, Eugene, Barth, Roman, Dekker, Cees
openaire +6 more sources
SMC complexes orchestrate the mitotic chromatin interaction landscape. [PDF]
Curr Genet, 2018 Chromatin is a very long DNA-protein complex that controls the expression and inheritance of the genetic information. Chromatin is stored within the nucleus in interphase and further compacted into chromosomes during mitosis. This process, known as chromosome condensation, is essential for faithful segregation of genomic DNA into daughter cells ...
Kakui Y, Uhlmann F.
europepmc +4 more sources
A low Smc flux avoids collisions and facilitates chromosome organization in Bacillus subtilis
eLife, 2021 SMC complexes are widely conserved ATP-powered DNA-loop-extrusion motors indispensable for organizing and faithfully segregating chromosomes. How SMC complexes translocate along DNA for loop extrusion and what happens when two complexes meet on the same ...
Anna Anchimiuk +5 more
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SMC complexes link gene expression and genome architecture. [PDF]
Curr Opin Genet Dev, 2014 The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expression and genome architecture.
Dowen JM, Young RA.
europepmc +6 more sources
An SMC-like protein binds and regulates Caenorhabditis elegans condensins. [PDF]
PLoS Genetics, 2017 Structural Maintenance of Chromosomes (SMC) family proteins participate in multisubunit complexes that govern chromosome structure and dynamics.
Lucy Fang-I Chao +4 more
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