Results 41 to 50 of about 46,383 (210)

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. [PDF]

, 2016
Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-specific binding to unintended membrane protein targets.
Carpenter, Elisabeth P, Gault, Joseph, Marcoux, Julien, Mehmood, Shahid, Michaelis, Susan, Quigley, Andrew, Robinson, Carol V, Young, Stephen G   +7 more
core   +2 more sources

Global Pandemic Conditions and List of Possible Medications and Vaccines for the Treatment of COVID-19: A Review

Borneo Journal of Pharmacy, 2020
At the end of December 2019, a novel coronavirus was identified which caused severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with a disease known as coronavirus disease 2019 (COVID-19).
Mohammad Mukim, Atul Kabra, Siwani Devi, Mohit Chaturvedi, Rakesh Patel   +4 more
doaj   +1 more source

COVID‐19: A review of therapeutics under investigation

Journal of the American College of Emergency Physicians Open, 2020
The COVID‐19 outbreak has disrupted global health care networks and caused thousands of deaths and an international economic downturn. Multiple drugs are being used on patients with COVID‐19 based on theoretical and in vitro therapeutic targets.
James C. Crosby, Matthew A. Heimann, Samuel L. Burleson, Brendan C. Anzalone, Jonathan F. Swanson, Douglas W. Wallace, Christopher J. Greene   +6 more
doaj   +1 more source

Brief Summary of Potential SARS-CoV-2 Prophylactic and Treatment Drugs in the Emergency Department [PDF]

, 2020
As of March 30th, 2020 there were 161,807 total cases and 2,953 total deaths of SARS-CoV-2 in the United States, with the number of cases expected to rise.
Brown, Cortlyn, Coralic, Zlatan, Noble, Jeanne   +2 more
core  

Novel reverse electrodialysis-driven iontophoretic system for topical and transdermal delivery of poorly permeable therapeutic agents

Drug Delivery, 2017
Topical and transdermal drug delivery has great potential in non-invasive and non-oral administration of poorly bioavailable therapeutic agents. However, due to the barrier function of the stratum corneum, the drugs that can be clinically feasible ...
Ki-Taek Kim, Joon Lee, Min-Hwan Kim, Ju-Hwan Park, Jae-Young Lee, Joo-Hyun Song, Minwoong Jung, Myoung-Hoon Jang, Hyun-Jong Cho, In-Soo Yoon, Dae-Duk Kim   +10 more
doaj   +1 more source

Amino Acid Prodrugs: An Approach to Improve the Absorption of HIV-1 Protease Inhibitor, Lopinavir

Pharmaceuticals, 2014
Poor systemic concentrations of lopinavir (LPV) following oral administration occur due to high cellular efflux by P-glycoprotein (P-gp) and multidrug resistance-associated proteins (MRPs) and extensive metabolism by CYP3A4 enzymes.
Mitesh Patel, Nanda Mandava, Mitan Gokulgandhi, Dhananjay Pal, Ashim K. Mitra   +4 more
doaj   +1 more source

Changes in insulin sensitivity over time and associated factors in HIV-infected adolescents [PDF]

, 2018
OBJECTIVE: To compare prevalence of insulin resistance between perinatally HIV-infected (PHIV+) and perinatally HIV-exposed, but uninfected adolescents (PHEU), determine incidence of and contributory factors to new and resolved cases of insulin ...
Dimeglio, Linda A., Geffner, Mitchell E., Gerschenson, Mariana, Hazra, Rohan, Jacobson, Denise L., Jao, Jennifer, Miller, Tracie L., Patel, Kunjal, Pediatric HIV/AIDS Cohort Study (PHACS), Sharma, Tanvi, Silio, Margarita, Takemoto, Jody K., Van Dyke, Russell B., Wu, Julia   +13 more
core   +2 more sources

Accelerating Generic Long‐Acting Antiretrovirals for Global HIV Treatment: Workshop Findings and a Roadmap to Access

Clinical Pharmacology &Therapeutics, EarlyView.
The global HIV response aims for widespread availability of affordable, quality‐assured long‐acting antiretroviral (LA ARV) drugs to achieve sustained epidemic control, particularly in low‐ and middle‐income countries. This report summarizes key discussion points, findings, and outcomes from an international workshop on generic LA ARVs, held in ...
Usman Arshad, Lobna Gaayeb, Henry Pertinez, Rajith K. R. Rajoli, Melynda Watkins, Parag Nimbolkar, Simone Perazzolo, Bharat Pagi, Annemarie Wensing, Saye Khoo, Marta Boffito, René Holm, Zack Panos, Imelda Mahaka, Francois Venter, Benny Kottiri, Keith W. Crawford, Rodney J. Y. Ho, Polly Clayden, Paul Domanico, Kimberly Struble, Andrew Owen, Charles Flexner   +22 more
wiley   +1 more source

Clinical and Immunological Outcomes after Initiation of Second Line Antiretroviral Therapy in People Living with HIV [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Resistance to first-line Antiretroviral Therapy (ART) has been a major concern in People Living with HIV (PLHIV), which necessitates a switch to second-line therapy.
BASAVAPRABHU ACHAPPA, DEEPAK MADI, MOHAMMAD YOUSUFF, SATISH RAO, JOHN RAMAPURAM   +4 more
doaj   +1 more source

Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]

, 2016
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A., Memish, Ziad A.
core   +1 more source