Results 51 to 60 of about 31,541 (206)

Enhanced Eryptosis Following Exposure to Lopinavir [PDF]

, 2015
Background/Aims: The protease inhibitor lopinavir, used for the treatment of HIV infections, triggers suicidal death or apoptosis of nucleated cells.
Abdulla Al Mamun Bhuyan, Salem Abbès, Rosi Bissinger, Rosi Bissinger, Florian Lang, Ghada Bouguerra, Sabrina Waibel   +6 more
core   +1 more source

Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment

Pharmaceuticals, 2022
The combination of lopinavir/ritonavir remains one of the first-line therapies for the initial antiretroviral regimen in pediatric HIV-infected children.
Azizah M. Malebari, Aytug Kara, Ahdab N. Khayyat, Khadijah A. Mohammad, Dolores R. Serrano   +4 more
doaj   +1 more source

Factors influencing lopinavir and atazanavir plasma concentration [PDF]

, 2010
The protease inhibitors lopinavir and atazanavir are both recommended for treatment of HIV-infected patients. Considerable inter-individual variability in plasma concentration has been observed for both drugs.
Back, David, M. Johnson, Easterbrook, Philippa, T. Hill, Anderson, Jane, David Dunn (37023), Leen, Clifford, Khoo, Saye, C. Leen, Teresa Hill (16119995), Hill, Teresa, Margaret Johnson (170613), Pillay, Deenan, Sabin, Caroline, Dunn, David, Wolfgang Stöhr (408365), Orkin, Chloe, W. Stohr, Loveleen Bansi (300126), Sara Gibbons (355647), Stoehr, Wolfgang, D. Dunn, Gilson, Richard, D. Pillay, Ainsworth, Jonathan, C. Orkin, Johnson, Margaret, J. Anderson, Gibbons, Sara, Alan Winston (316046), Philippa Easterbrook (70407), Saye Khoo (575924), Richard Gilson (125405), Fisher, Martin, B. Gazzard, Deenan Pillay (7888), S. Gibbons, Martin Fisher (300134), Bansi, Loveleen, Winston, Alan, Caroline Sabin (252688), J. Ainsworth, C. Sabin, L. Bansi, Chloe Orkin (254460), Brian Gazzard (4921), Jane Anderson (63637), R. Gilson, M. Fisher, S. Khoo, P. Easterbrook, David Back (355646), Gazzard, Brian, A. Winston, D. Back, Jonathan Ainsworth (225537), Clifford Leen (408371)   +56 more
core   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Structural and molecular characterization of lopinavir and ivermectin as breast cancer resistance protein (BCRP/ABCG2) inhibitors

EXCLI Journal : Experimental and Clinical Sciences, 2023
A current clinical challenge in cancer is multidrug resistance (MDR) mediated by ABC transporters. Breast cancer resistance protein (BCRP) or ABCG2 transporter is one of the most important ABC transporters implicated in MDR and the use of inhibitors is a
Julia de Paula Dutra, Gustavo Scheiffer, Thales Kronenberger, Lucas Julian Cruz Gomes, Isadora Zanzarini, Kelly Karoline dos Santos, Arun K. Tonduru, Antti Poso, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Glaucio Valdameri, Vivian Rotuno Moure   +11 more
doaj   +1 more source

Lipid disorders in antiretroviral-naive patients treated with lopinavir/ritonavir-based HAART: frequency, characterization and risk factors [PDF]

, 2005
Objectives: The aim of this study was to evaluate the frequency, characteristics and risk factors of lipid changes associated with lopinavir/ritonavir treatment in antiretroviral-naive patients.
Arribas, José R., Rubio García, Rafael, Montes, María Luisa   +2 more
core   +1 more source

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio, Antonio José Martinez‐Mellado, Jonathan Kiwitt‐Cárdenas, José G. Clavel, Bartolomé García‐Perez, Pedro Castro, Maribel Diaz‐Ricart, Andrés Carrillo‐Alcaraz, Amparo López‐Bernús, Enrique Bernal Morell, Aychel Roura, Sonia Marín, Francisco‐José Ruiz‐López, Elena Solana‐Martinez, Domingo Martinez‐Baño, Carlos L. Albacete Moreno, Enriqueta Andreu Soler, Adrián Tellez Santoyo, Sara Fernández Méndez, Jose A. Noguera Velasco, Iria Cebreiros Lopez, Andrés Parrilla, Alberto Espuny‐Miró, David García‐Bernal, Miguel Blanquer, Andrés Sánchez‐Salinas, Francisca Iniesta, Cristina Hernandez Garcia, Manuel Muro, Alfredo Minguela Puras, Antonio Moreno‐Docón, Alberto M. Torres‐Cantero, Maria Munoz Garcia, Manuel Serrano, Massimo Iacobelli, Carmelo Carlo‐Stella, Lee‐Jen Wei, Paul G. Richardson, José M. Moraleda   +38 more
wiley   +1 more source

Factors associated with clinical, immunological and virological responses in protease-inhibitor-experienced brazilian children receiving highly active antiretroviral therapy containing Lopinavir-Ritonavir

Brazilian Journal of Infectious Diseases
This study evaluates clinical, virological and immunological responses to antiretroviral (ARV) therapy based on Lopinavir/ritonovir (LPV/r) in previously protease -inhibitor-experienced children.
Daisy Maria Machado, Aída de Fátima Barbosa Gouvêa, Maria Regina Cardoso, Suênia Vasconcelos Beltrão, Kelly Simone Cunegundes, Fabiana Bononi, Fernanda Almeida, Kaline Cavalheiro, Daniela Souza Araújo de Angelis, Regina Célia de Menezes Succi   +9 more
doaj   +1 more source

Tinjauan Keamanan Penggunaan Lopinavir dan Ritonavir Untuk Terapi Covid-19 Pada Anak [PDF]

, 2021
Kombinasi Lopinavir dan Ritonavir merupakan salah satu obat yang golongan antiviral yang digunakan sebagai terapi potensial untuk pengobatan pada pasien COVID-19. Efektivitas penggunaan Lopinavir dan Ritonavir pada pasien COVID-19 masih dalam uji klinis.
Suyasa, Agus Baratha, Lewar, Emanuel Ileatan   +1 more
core   +1 more source

Safety and Effectiveness of Glecaprevir/Pibrentasvir in Children and Adolescents With Chronic Hepatitis C: Reports From All‐Case Post‐Marketing Surveillance in Japan

Hepatology Research, EarlyView.
ABSTRACT Aim The aim of this all‐case post‐marketing study was to evaluate the real‐world safety and effectiveness in all children and adolescents with chronic hepatitis C with or without compensated cirrhosis treated with glecaprevir/pibrentasvir (G/P) in Japan. Methods This prospective, observational post‐marketing surveillance study was conducted at
Tatsuki Mizuochi, Katsuyoshi Kawana, Mariko Kobayashi, Eri Iwashita, Itaru Iwama, Daiki Abukawa, Hitoshi Tajiri   +6 more
wiley   +1 more source