Results 51 to 60 of about 32,499 (205)

Virus‐specific alterations in placental structure and transporter expression following maternal arbovirus infection

The Journal of Physiology, EarlyView.
Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade, Enrrico Bloise, Natália L. Silva, Jair R. S. Braga, Sharton V. A. Coelho, Veronica M. O. Nascimento, Guinever E. Imperio, Camila O. S. Nunes, Antônio J. L. A. Cunha, Marcelo A. Pascoal‐Xavier, Luciana B. Arruda, Arnaldo Prata‐Barbosa, Kristin L. Connor, Tania M. Ortiga‐Carvalho   +13 more
wiley   +1 more source

Impact of body weight and missed doses on lopinavir concentrations with standard and increased lopinavir/ritonavir doses during late pregnancy

, 2015
OBJECTIVES: To assess the influence of body weight and missed doses on lopinavir pharmacokinetics with standard and increased doses of lopinavir/ritonavir melt extrusion tablets during late pregnancy.
Rawangban, Boonsong, Lallemant, Marc, Urien, Saik, Treluyer, Jean-Marc, Buranabanjasatean, Sudanee, Sabsanong, Prapan, Jourdain, Gonzague, Best, Brookie M, Limtrakul, Aram, Cressey, Tim R, Capparelli, Edmund V, Stek, Alice, Mirochnick, Mark   +12 more
core   +2 more sources

Factors associated with clinical, immunological and virological responses in protease-inhibitor-experienced brazilian children receiving highly active antiretroviral therapy containing Lopinavir-Ritonavir

Brazilian Journal of Infectious Diseases
This study evaluates clinical, virological and immunological responses to antiretroviral (ARV) therapy based on Lopinavir/ritonovir (LPV/r) in previously protease -inhibitor-experienced children.
Daisy Maria Machado, Aída de Fátima Barbosa Gouvêa, Maria Regina Cardoso, Suênia Vasconcelos Beltrão, Kelly Simone Cunegundes, Fabiana Bononi, Fernanda Almeida, Kaline Cavalheiro, Daniela Souza Araújo de Angelis, Regina Célia de Menezes Succi   +9 more
doaj   +1 more source

Determination of lopinavir/ritonavir concentrations in four different oral solutions for the application of antiretroviral therapy in very young, HIV-1-infected children

Southern African Journal of HIV Medicine, 2021
No abstract available.
Nils von Hentig, Carlo Angioni, Christoph Königs   +2 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2138-2142, October 2026.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Evaluation of the efficacy and safety of oral N‐acetylcysteine in patients with COVID‐19 receiving the routine antiviral and hydroxychloroquine protocol: A randomized controlled clinical trial

Immunity, Inflammation and Disease, 2023
Background The current absence of gold‐standard or all‐aspect favorable therapies for COVID‐19 renders a focus on multipotential drugs proposed to prevent or treat this infection or ameliorate its signs and symptoms vitally important.
Najmolsadat Atefi, Azadeh Goodarzi, Taghi Riahi, Niloofar Khodabandehloo, Mahshid Talebi Taher, Niloufar Najar Nobari, Farnoosh Seirafianpour, Zeinab Mahdi, Amir Baghestani, Rohollah Valizadeh   +9 more
doaj   +1 more source

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3656-3665, October 2026.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Cerebrospinal fluid and plasma HIV-1 RNA levels and lopinavir concentrations following lopinavir/ritonavir regimen

, 2004
Our objective was to study the effect of lopinavir/ritonavir on cerebrospinal fluid (CSF) viral load as part of an antiretroviral combination treatment for HIV-1 infected individuals, and to determine the steady-state concentrations of lopinavir in CSF ...
Fuchs, Dietmar, Gisslén, Magnus,, Yilmaz, Aylin,, Ståhle, Lars, Hagberg, Lars,, Svennerholm, Bo,   +5 more
core   +1 more source

Current Clinical Trials and Vaccine Development Strategies for Corona Virus Disease (COVID-19)

Journal of Pure and Applied Microbiology, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has reached global epidemic status claiming more than 319K lives and affecting more than 4.81M people and counting worldwide.
Abhi Bhadra, Shweta Singh, Shaswat Chandrakar, Vanshika Kumar, Sakshi Sankhla, Sayuj Raj T., E. Selvarajan   +6 more
doaj   +1 more source

Assessment of Knowledge and Attitudes Toward Potential Drug–Drug and Drug–Food Interactions and Associated Factors Among Health Care Professionals at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims The increased likelihood of potential drug–drug interactions (PDDIs) and food–drug interactions (FDIs) is primarily attributed to the increasing use of multiple medications and the practice of taking medicines with food. Healthcare professionals' (HCPs') knowledge and attitudes toward PDDIs and FDIs play a critical role in ...
Melese Legesse Mitku, Yeniewa Kerie Anagaw, Abera Dessie Dagnaw, Derso Teju Geremew, Yeshiwas Ayale Ferede, Tewodros Denekew Haile, Minichil Chanie Worku, Liknaw Workie Limenh, Azmeraw Bekele, Wondim Ayenew   +9 more
wiley   +1 more source