Results 71 to 80 of about 32,499 (205)

Structural representations with Lopinavir interactions.

, 2013
(A) Displaying active site of the PvPM-V Sal-1 (wild type) and its interaction with only known inhibitor lopinavir (red) (B) Displaying active site of the PvPM-V-Ind (mutant) and its interaction with known inhibitor lopinavir (red). The docked lopinavir (
Manmeet Rawat (353685), Sonam Vijay (353683), Pramod Kumar Tiwari (396627), Arun Sharma (153522), Yash Gupta (396626)   +4 more
core   +1 more source

Electrospun Amorphous Solid Dispersions with Lopinavir and Ritonavir for Improved Solubility and Dissolution Rate

Nanomaterials
Lopinavir (LPV) and ritonavir (RTV) are two of the essential antiretroviral active pharmaceutical ingredients (APIs) characterized by poor solubility. Hence, attempts have been made to improve both their solubility and dissolution rate.
Ewelina Łyszczarz, Oskar Sosna, Justyna Srebro, Aleksandra Rezka, Dorota Majda, Aleksander Mendyk   +5 more
doaj   +1 more source

Novel reverse electrodialysis-driven iontophoretic system for topical and transdermal delivery of poorly permeable therapeutic agents

Drug Delivery, 2017
Topical and transdermal drug delivery has great potential in non-invasive and non-oral administration of poorly bioavailable therapeutic agents. However, due to the barrier function of the stratum corneum, the drugs that can be clinically feasible ...
Ki-Taek Kim, Joon Lee, Min-Hwan Kim, Ju-Hwan Park, Jae-Young Lee, Joo-Hyun Song, Minwoong Jung, Myoung-Hoon Jang, Hyun-Jong Cho, In-Soo Yoon, Dae-Duk Kim   +10 more
doaj   +1 more source

Validation of an UHPLC–MS/MS Assay for the Quantification of Isoniazid and Four Major Metabolites in Human Plasma

Biomedical Chromatography, Volume 40, Issue 9, September 2026.
ABSTRACT Isoniazid (INH) is a key component of tuberculosis treatment regimens but is also associated with hepatotoxicity. This toxicity is mediated in part by its metabolites, but some degrade rapidly in plasma. A rapid freeze/thaw process with a methanol protein precipitation extraction was developed to slow the rapid degradation of acetylisoniazid ...
David Nerguizian, Brandon Klein, Farah Abdelmawla, Joe Gomez, Peter L. Anderson, Lane Bushman, Kristina M. Brooks   +6 more
wiley   +1 more source

Safety of Prenatal Anti‐Infective Use and Offspring Outcomes: A Panoramic Assessment by Indication, Drug Class, and Exposure Characteristics

iMetaMed, Volume 2, Issue 3, September 2026.
Based on the comprehensive, panoramic assessment of the safety of prenatal anti‐infective use across indications, drug classes, and exposure characteristics, potential safety signals associated with prenatal exposure to several widely used anti‐infective drug classes were identified, including macrolides, metronidazole, tetracyclines, sulfonamides ...
Wenling Wang, Yuezhen Li, Chunrong Liu, Chen Chen, Meng Chen, Lehana Thabane, Xin Sun, Jing Tan   +7 more
wiley   +1 more source

Population pharmacokinetics of lopinavir/ritonavir in Covid-19 patients

, 2021
International audienceObjective: To develop a population pharmacokinetic model for lopinavir boosted by ritonavir in coronavirus disease 2019 (Covid-19) patients.Methods: Concentrations of lopinavir/ritonavir were assayed by an accredited LC-MS/MS method.
Etting, Isabelle, Alvarez, Jean, Claude, Annane, Djillali, Larabi, Islam Amine, Simon, Nicolas, Moine, Pierre, Davido, Benjamin   +6 more
core   +1 more source

Ursodeoxycholic Acid Reduces Angiotensin‐Converting Enzyme 2 Activity and Suppresses Cytokine Storm Syndrome in Patients With Coronavirus Disease 2019

MedComm, Volume 7, Issue 9, September 2026.
SARS‐CoV‐2 infection causes COVID‐19 and stimulates immune cells, such as dendritic cells, monocytes, and macrophages, to increase levels of many cytokines. Ursodeoxycholic acid (UDCA) inhibits farnesoid X receptor (FXR), resulting in a decrease in the activity of angiotensin‐converting enzyme 2 (ACE2), the main receptor on the membrane for SARS‐CoV‐2.
Zhaowei Tong, Jiawei Zhu, Jianfeng Zhong, Qi Wang, Fuchu Qian, Lili Zhao, Weihong Wang, Yuepao Cai, Kefeng Qin   +8 more
wiley   +1 more source

Model‐Based Tacrolimus Dosing Using the Population Pharmacokinetic Analysis Under the Nirmatrelvir/Ritonavir Therapy

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Nirmatrelvir/ritonavir is an antiviral agent used against severe acute respiratory syndrome coronavirus 2 infection and inhibits cytochrome P450 3A and P‐glycoprotein. The concomitant use of nirmatrelvir/ritonavir markedly increases tacrolimus blood concentrations. Although temporary discontinuation or dose reduction of tacrolimus at the start
Kotaro Itohara, Yoshiki Katada, Takahiro Hatayama, Toshiaki Igarashi, Jiro Ogura, Tomoki Fukushima, Shingo Yamazaki, Masato Homma, Takashi Niwa, Yoshiaki Kato, Nanae Yamamoto, Hideyuki Terazono, Hideo Shiohira, Tomohiro Terada, Ikuko Yano   +14 more
wiley   +1 more source

Structural multiplicity in a solvated hydrate of the antiretroviral protease inhibitor Lopinavir

Acta Crystallographica Section E: Crystallographic Communications
Lopinavir is a potent protease inhibitor that is used as a first-line pharmaceutical drug for the treatment of HIV. The multi-component solvated Lopinavir crystal, systematic name (2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6 ...
Tebogo M. L. Mokoto, Andreas Lemmerer, Yasien Sayed, Mark G. Smith   +3 more
doaj   +1 more source

Investigating the Short‐Term Changes of the Electrocardiogram Indicators During Hospitalization in Patients With COVID‐19 Following the Use of Tocilizumab

Annals of Noninvasive Electrocardiology, Volume 31, Issue 5, September 2026.
Tocilizumab, an IL‐6 inhibitor used in severe COVID‐19, may have cardiovascular effects. This study examined short‐term electrocardiographic (ECG) changes 24 h before versus 24 h after tocilizumab injection in PCR‐positive COVID‐19 patients. Retrospective study of 33 ICU‐admitted COVID‐19 patients (36.4% male, age 37–79 years). ECG parameters including
Mahdi Zahedi, Golnaz Houshmand, Tabassom Hosseini   +2 more
wiley   +1 more source