Results 71 to 80 of about 46,511 (209)

KSHV Genome in Saliva, Whole Blood and Kaposi's Sarcoma Biopsy Specimens in Republic of Congo: Phylogenetic Analysis and an APOBEC3B Mutational Signature

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT Kaposi's sarcoma‐associated herpesvirus (KSHV) has been associated with a variety of diseases and is endemic in Sub‐Saharan Africa. We performed KSHV‐whole‐genome analysis and search for APOBEC‐editing to describe genetic diversity in samples issued from an endemic region.
Gervillien Arnold Malonga, Valentin Leducq, Antoine Fauchois, Dimitry Moudiongui Mboungou Malanda, Patrina Joseph Iloukou Mayakia, Juthèce Private Malanda‐Kiminou, Ferdinand Emaniel Brel Got, Fabien Gaël Mouamba, Vincent Calvez, Jean Felix Peko, Anne‑Geneviève Marcelin, Aude Jary   +11 more
wiley   +1 more source

A Phase 1 Multiple‐Dose, Open‐Label, Pharmacokinetic Study of Nirmatrelvir/Ritonavir in Healthy Lactating Women

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT In accordance with the Centers for Disease Control and Prevention recommendations, pregnant women and those with a recent pregnancy (i.e., lactating) are considered at high risk of developing severe COVID‐19 and qualify for treatment with nirmatrelvir/ritonavir.
Jacqueline Gerhart, Narayan Cheruvu, Kathleen Pelletier, Kyle Matschke, Haihong Shi, Josué Kunjom Mfopou, Jennifer Hammond, Ravi Shankar P. Singh   +7 more
wiley   +1 more source

Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-Infected Adults [PDF]

, 2012
Background—The organic anion transporting polypeptides (OATP)/SLCO family represents an important class of hepatic drug uptake transporters that mediate the sodium independent transport of a diverse range of amphipathic organic compounds, including the ...
Back, D.J., Boffito, M, Davies, G, Dickinson, L, Egan, D, Khoo, S. H., Owen, A, Schipani, A, Youle, M   +8 more
core   +1 more source

Associations of SLCO1B1 polymorphism with virological efficacy in children with HIV infection

Сибирский научный медицинский журнал
The aim of the study was to identify the association between polymorphism of the SLCO1B1 gene and virological efficacy in children receiving lopinavir as part of their antiretroviral therapy.Material and methods.
A. Yu. Sambyalova, T. A. Bairova, T. L. Eletskaya, A. V. Belskikh, E. V. Belyaeva, O. A. Ershova, N. V. Nemchinova, V. V. Sinkov, Yu. K. Plotnikova, L. V. Rychkova   +9 more
doaj   +1 more source

Preventing Mother to Child Transmission of Human Immunodeficiency Virus: 20‐Year Trends in Management and Clinical Practice in a French Hospital – A Retrospective Observational Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Since the discovery of human immunodeficiency virus (HIV) mother to child transmission (MTCT), its prevention has been a priority. Guideline adherence has drastically reduced MTCT, virtually inexistent today in high‐income countries.
Boris Dmitrenko, Emmanuelle Vintejoux, Florent Fuchs, Joana Pissarra, Lionel Moulis, Philippe Van de Perre   +5 more
wiley   +1 more source

Mycobacterium avium subspecies paratuberculosis bacteremia in type 1 diabetes mellitus: an infectious trigger? [PDF]

, 2008
Mycobacterium avium subspecies paratuberculosis (MAP) is the established cause of paratuberculosis in ruminants (i.e., Johne disease). The bacterium is shed in the milk of infected cows and survives pasteurization.
Paccagnini, Daniela, Salza, Sara, Sechi, Leonardo Antonio   +2 more
core  

COVID-19 Infection: Implications for Perioperative and Critical Care Physicians. [PDF]

, 2020
Healthcare systems worldwide are responding to Coronavirus Disease 2019 (COVID-19), an emerging infectious syndrome caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Patients with COVID-19 can progress from asymptomatic or
Greenland, John R, London, Martin J, Michelow, Marilyn D, Wang, Linlin   +3 more
core  

Systemic inflammation and residual viraemia in HIV-positive adults on protease inhibitor monotherapy: a cross-sectional study. [PDF]

, 2015
Increased levels of markers of systemic inflammation have been associated with serious non-AIDS events even in patients on fully suppressive antiretroviral therapy.
Arenas-Pinto, A, Gilson, R, Maini, M, McKendry, A, Milinkovic, A, Peppa, D   +5 more
core   +1 more source

Factors associated with clinical, immunological and virological responses in protease-inhibitor-experienced brazilian children receiving highly active antiretroviral therapy containing Lopinavir-Ritonavir

Brazilian Journal of Infectious Diseases
This study evaluates clinical, virological and immunological responses to antiretroviral (ARV) therapy based on Lopinavir/ritonovir (LPV/r) in previously protease -inhibitor-experienced children.
Daisy Maria Machado, Aída de Fátima Barbosa Gouvêa, Maria Regina Cardoso, Suênia Vasconcelos Beltrão, Kelly Simone Cunegundes, Fabiana Bononi, Fernanda Almeida, Kaline Cavalheiro, Daniela Souza Araújo de Angelis, Regina Célia de Menezes Succi   +9 more
doaj   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source