Results 81 to 90 of about 32,499 (205)

Randomised pharmacokinetic trial of rifabutin with lopinavir/ritonavir-antiretroviral therapy in patients with HIV-associated tuberculosis in Vietnam.

PLoS ONE, 2014
BackgroundRifampicin and protease inhibitors are difficult to use concomitantly in patients with HIV-associated tuberculosis because of drug-drug interactions. Rifabutin has been proposed as an alternative rifamycin, but there is concern that the current
Nguyen Thi Ngoc Lan, Nguyen Thi Nguyet Thu, Aurélie Barrail-Tran, Nguyen Hong Duc, Nguyen Ngoc Lan, Didier Laureillard, Truong Thi Xuan Lien, Laurence Borand, Catherine Quillet, Catherine Connolly, Dominique Lagarde, Alexander Pym, Christian Lienhardt, Nguyen Huy Dung, Anne-Marie Taburet, Anthony D Harries   +15 more
doaj   +1 more source

Improved Oral Bioavailability of Lopinavir in Melt-Extruded Tablet Formulation Reduces Impact of Third Trimester on Lopinavir Plasma Concentrations

, 2012
Lopinavir exposure was reduced during the third trimester in pregnant women receiving standard dosing of the soft-gel capsule (SGC; 400/100 mg twice daily [b.i.d.]). Pharmacokinetic data on the lopinavir tablet in pregnancy are limited.
L. Dickinson, S. H. Khoo, L. J. Else, M. Douglas, G. P. Taylor, D. J. Back   +5 more
core   +1 more source

The Australasian COVID-19 Trial (ASCOT) to assess clinical outcomes in hospitalised patients with SARS-CoV-2 infection (COVID-19) treated with lopinavir/ritonavir and/or hydroxychloroquine compared to standard of care: A structured summary of a study protocol for a randomised controlled trial

Trials, 2020
Objectives To determine if lopinavir/ritonavir +/- hydroxychloroquine will reduce the proportion of participants who survive without requiring ventilatory support, 15 days after enrolment, in adult participants with non-critically ill SARS-CoV-2 ...
Justin T. Denholm, Joshua Davis, David Paterson, Jason Roberts, Susan Morpeth, Thomas Snelling, Dominica Zentner, Megan Rees, Matthew O’Sullivan, David Price, Asha Bowen, Steven Y. C. Tong, for the ASCOT Investigator Group   +12 more
doaj   +1 more source

HIV drug resistance and treatment success in the Republic of Congo: Implications for optimized treatment

HIV Medicine, Volume 27, Issue 9, Page 1421-1433, September 2026.
Abstract Objectives Increasing rates of HIV‐1 drug resistance (HIVDR) threaten the effectiveness of antiretroviral therapy (ART) programmes in sub‐Saharan Africa, particularly among children, adolescents and young adults, who face limited treatment options.
Dominic Rauschning, Arcy Marcelin Elenga Ike, Johanna Holterhoff, Amira Stockinger, Darrel Ornelle Elion Assiana, Claujens Chastel Mfoutou Mapanguy, Freisnel Hermeland Mouzinga, Carola Horn, Isabelle Suarez, Ferdinand Heyn, Diane Alexia Fila, Hubert Banguissa, Fabien Roch Niama, Donatien Moukassa, Eva Heger, Francine Ntoumi, Clara Lehmann   +16 more
wiley   +1 more source

Factors influencing lopinavir and atazanavir plasma concentration

, 2010
The protease inhibitors lopinavir and atazanavir are both recommended for treatment of HIV-infected patients. Considerable inter-individual variability in plasma concentration has been observed for both drugs.
Back, David, M. Johnson, Easterbrook, Philippa, T. Hill, Anderson, Jane, David Dunn (37023), Leen, Clifford, Khoo, Saye, C. Leen, Teresa Hill (16119995), Hill, Teresa, Margaret Johnson (170613), Pillay, Deenan, Sabin, Caroline, Dunn, David, Wolfgang Stöhr (408365), Orkin, Chloe, W. Stohr, Loveleen Bansi (300126), Sara Gibbons (355647), Stoehr, Wolfgang, D. Dunn, Gilson, Richard, D. Pillay, Ainsworth, Jonathan, C. Orkin, Johnson, Margaret, J. Anderson, Gibbons, Sara, Alan Winston (316046), Philippa Easterbrook (70407), Saye Khoo (575924), Richard Gilson (125405), Fisher, Martin, B. Gazzard, Deenan Pillay (7888), S. Gibbons, Martin Fisher (300134), Bansi, Loveleen, Winston, Alan, Caroline Sabin (252688), J. Ainsworth, C. Sabin, L. Bansi, Chloe Orkin (254460), Brian Gazzard (4921), Jane Anderson (63637), R. Gilson, M. Fisher, S. Khoo, P. Easterbrook, David Back (355646), Gazzard, Brian, A. Winston, D. Back, Jonathan Ainsworth (225537), Clifford Leen (408371)   +56 more
core   +1 more source

Pharmacogenomics landscape of COVID-19 therapy response in Serbian population and comparison with worldwide populations [PDF]

Journal of Medical Biochemistry, 2020
Background: Since there are no certified therapeutics to treat COVID-19 patients, drug repurposing became important. With lack of time to test individual pharmacogenomics markers, population pharmacogenomics could be helpful in predicting a higher risk ...
Stanković Biljana, Kotur Nikola, Gašić Vladimir, Klaassen Kristel, Ristivojević Bojan, Stojiljković Maja, Pavlović Sonja, Zukić Branka   +7 more
doaj  

Thai Transplant Care Practice Guideline on Immunosuppressive Therapy for Adult Kidney Transplantation

Nephrology, Volume 31, Issue S2, September 2026.
ABSTRACT The Thai Transplantation Society developed these clinical practice guidelines to establish a comprehensive standard for immunosuppressive therapy in adult kidney transplantation. While rooted in evidence‐based medicine, the objective of this document extends beyond local application, serving as a practical model for low‐to‐middle‐income ...
Suwasin Udomkarnjananun, Napun Sutharattanapong, Nuttasith Larpparisuth, Korntip Phonphok, Tanun Ngamvichchukorn, Peenida Skulratanasak, Pitchamon Inkong, Suwikran Wongpraphairot, Opas Traitanon, Piyavadee Homkrailas, Kajohnsak Noppakun, Natavudh Townamchai, on behalf of Thai Transplantation Society   +12 more
wiley   +1 more source

Intervenciones farmacológicas para el tratamiento de la Enfermedad por Coronavirus (COVID-19)

Anales de la Facultad de Medicina, 2020
Varios fármacos han sido propuestos como alternativas terapéuticas para COVID-19. Se efectuó una búsqueda sistematica en MEDLINE (vía PubMed) hasta el 20 de marzo de 2020, con el fin de identificar la evidencia disponible sobre intervenciones ...
Fabiola Huaroto, Nora Reyes, Karen Huamán, Catherine Bonilla, Maricela Curisinche-Rojas, Gloria Carmona, Ericson Gutierrez, Patricia Caballero   +7 more
doaj   +1 more source

Analysis of some antiretroviral drugs in bulk, pharmaceutical formulations and biological fluid [PDF]

, 2012
Not ...
Mardia, Rajnikant B.
core  

Associations of SLCO1B1 polymorphism with virological efficacy in children with HIV infection

Сибирский научный медицинский журнал
The aim of the study was to identify the association between polymorphism of the SLCO1B1 gene and virological efficacy in children receiving lopinavir as part of their antiretroviral therapy.Material and methods.
A. Yu. Sambyalova, T. A. Bairova, T. L. Eletskaya, A. V. Belskikh, E. V. Belyaeva, O. A. Ershova, N. V. Nemchinova, V. V. Sinkov, Yu. K. Plotnikova, L. V. Rychkova   +9 more
doaj   +1 more source