Results 61 to 70 of about 32,499 (205)
Frontiers in Cellular and Infection MicrobiologyBackgroundDrug repurposing has become a widely adopted strategy to minimise research time, costs, and associated risks. Combinations of protease inhibitors such as lopinavir and darunavir with ritonavir have been repurposed as treatments for COVID-19 ...
Dóra Paróczai +13 more
doaj +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Thymic involution, the age‐related replacement of thymic soft tissue by fat, has been linked to immunosenescence and chronic inflammation. Whether HIV infection affects thymic involution remains unclear. We found that people with HIV on long‐term antiretroviral therapy had more thymic tissue than controls, indicating less thymic involution. More thymic
Manon C. Vanbellinghen +15 more
wiley +1 more source
, 2020 Background. Human immunodeficiency virus (HIV)-associated tuberculosis is difficult to treat, given the propensity for drug interactions between the rifamycins and the antiretroviral drugs.
• Rifabutin With Lopinavir-Ritonavir +1 more
core
, 2007 Week 48 HIV-RNA treatment response to the protease inhibitor tipranavir co-administered with ritonavir was compared with that of lopinavir co-administered with ritonavir in patients whose baseline isolates had varying lopinavir genotypic mutation scores.
S. L. Walmsley +7 more
core +1 more source
Медицинский вестник Юга России, 2018 Objective: to characterize the efcacy of nelfnavir and lopinavir/ritonavir in the starting regimens of antiretroviral therapy for HIV-infected pediatric patients.Materials and methods: 50 HIV-infected patients aged 24-36 months were treated with abacavir
V. B. Denisenko,, E. N. Simovanyan
doaj +1 more source
Pharmaceutical Sciences and Research, 2020 Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and can be aggravated by comorbid diseases.
Ana Khusnul Faizah +2 more
doaj +1 more source
European Journal of Haematology, Volume 117, Issue 4, Page 922-935, October 2026.ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio +38 more
wiley +1 more source
Formulation, Development and Evaluation of Lopinavir Loaded Polymeric Micelles [PDF]
, 2020 : Lopinavir is the anti HIV drug which is used to treat the HIV-1 infection. In this study we used the single lopinavir drug to formulate the polymeric micelle. This study was done with the two main objectives as Objective:first to enhance the solubility
Shilpa Praveen. Chaudhari, +1 more
core +1 more source
, 2011 Background: Coadministration of rifampicin dramatically reduces the concentrations of protease inhibitors. A pharmacokinetic study in healthy adults showed that doubling the dose of coformulated lopinavir/ritonavir was able to overcome the inducing ...
Nuttall J. +10 more
core +2 more sources
Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy
Advanced Science, Volume 13, Issue 54, 28 September 2026.ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin +8 more
wiley +1 more source