Results 41 to 50 of about 46,511 (209)

Diagnosis and Management of COVID-19 Disease [PDF]

, 2020
SARS-CoV-2 is a novel coronavirus that was identified in late 2019 as the causative agent of COVID-19 (aka coronavirus disease 2019). On March 11, 2020, the World Health Organization (WHO) declared the world-wide outbreak of COVID-19 a pandemic.
Carlos, Graham, Dela Cruz, Charles S., Gross, Jane E., Jamil, Shazia, Mark, Nick, Pasnick, Susan   +5 more
core   +1 more source

COVID‐19: A review of therapeutics under investigation

Journal of the American College of Emergency Physicians Open, 2020
The COVID‐19 outbreak has disrupted global health care networks and caused thousands of deaths and an international economic downturn. Multiple drugs are being used on patients with COVID‐19 based on theoretical and in vitro therapeutic targets.
James C. Crosby, Matthew A. Heimann, Samuel L. Burleson, Brendan C. Anzalone, Jonathan F. Swanson, Douglas W. Wallace, Christopher J. Greene   +6 more
doaj   +1 more source

Novel reverse electrodialysis-driven iontophoretic system for topical and transdermal delivery of poorly permeable therapeutic agents

Drug Delivery, 2017
Topical and transdermal drug delivery has great potential in non-invasive and non-oral administration of poorly bioavailable therapeutic agents. However, due to the barrier function of the stratum corneum, the drugs that can be clinically feasible ...
Ki-Taek Kim, Joon Lee, Min-Hwan Kim, Ju-Hwan Park, Jae-Young Lee, Joo-Hyun Song, Minwoong Jung, Myoung-Hoon Jang, Hyun-Jong Cho, In-Soo Yoon, Dae-Duk Kim   +10 more
doaj   +1 more source

Amino Acid Prodrugs: An Approach to Improve the Absorption of HIV-1 Protease Inhibitor, Lopinavir

Pharmaceuticals, 2014
Poor systemic concentrations of lopinavir (LPV) following oral administration occur due to high cellular efflux by P-glycoprotein (P-gp) and multidrug resistance-associated proteins (MRPs) and extensive metabolism by CYP3A4 enzymes.
Mitesh Patel, Nanda Mandava, Mitan Gokulgandhi, Dhananjay Pal, Ashim K. Mitra   +4 more
doaj   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Positive Outcomes of HAART at 24 Months in HIV-Infected Patients in Cambodia. [PDF]

, 2007
OBJECTIVES: African and Asian cohort studies have demonstrated the feasibility and efficacy of HAART in resource-poor settings. The long-term virological outcome and clinico-immunological criteria of success remain important questions.
Bartlett, Bartlett, Bourgeois, Calmy, Calmy, Carrieri, Carrieri, Coetzee, Colebunders, Colebunders, Dabis, Ferradini, Gill, Gonzalez de, Grabar, Ivers, Kumarasamy, Laurent, Laurent, Lawn, Lawn, Lawn, Le Moing, Ly, Madec, Marzolini, Orrell, Pasquier, Rouet, Rouzioux, Severe, Tassie, Van Heeswijk, Weidle, Wu, Zhou   +35 more
core   +2 more sources

Clinical and Immunological Outcomes after Initiation of Second Line Antiretroviral Therapy in People Living with HIV [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Resistance to first-line Antiretroviral Therapy (ART) has been a major concern in People Living with HIV (PLHIV), which necessitates a switch to second-line therapy.
BASAVAPRABHU ACHAPPA, DEEPAK MADI, MOHAMMAD YOUSUFF, SATISH RAO, JOHN RAMAPURAM   +4 more
doaj   +1 more source

Population Pharmacokinetics of Ticagrelor during Veno‐Arterial ECMO in Acute Coronary Syndrome: Model‐Informed Dosing Simulations

Clinical Pharmacology &Therapeutics, EarlyView.
Although patients with acute coronary syndrome supported by veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) have a high risk of thrombosis and bleeding, antiplatelet pharmacology in this setting is not well defined. This prospective observational study investigated the population pharmacokinetics of ticagrelor and its active metabolite AR ...
Soyoung Kang, Kyoung Lok Min, Seungwon Yang, Jongsung Hahn, Dasohm Kim, Byung Hak Jin, Soon Uk Chae, Soo Kyung Bae, Jin Wi, Min Jung Chang   +9 more
wiley   +1 more source

Development of Advanced 3D-Printed Solid Dosage Pediatric Formulations for HIV Treatment

Pharmaceuticals, 2022
The combination of lopinavir/ritonavir remains one of the first-line therapies for the initial antiretroviral regimen in pediatric HIV-infected children.
Azizah M. Malebari, Aytug Kara, Ahdab N. Khayyat, Khadijah A. Mohammad, Dolores R. Serrano   +4 more
doaj   +1 more source

Unintended Consequences of Life‐Saving Pharmaceutical Innovations: How HAART Led to the Resurgence of Syphilis

Health Economics, EarlyView.
ABSTRACT Syphilis, a sexually transmitted infection that can lead to serious health complications, was almost eliminated in the United States by 2000. But since then, its incidence began to increase, recently reaching a 60‐year peak. We suggest that the introduction of the highly active antiretroviral therapy (HAART) drug regimen, which transformed HIV
David Beheshti, Scott Cunningham, Nir Eilam   +2 more
wiley   +1 more source