Results 41 to 50 of about 31,541 (206)

Yindan Jiedu Granules, a Traditional Chinese Medicinal Formulation, as a Potential Treatment for Coronavirus Disease 2019

Frontiers in Pharmacology, 2021
Background:YindanJiedu Granules (YDJDG) have been newly prescribed as a Chinese herbal formula. This study aimed to compare the efficacy of YDJDG and lopinavir-ritonavir in the treatment of coronavirus disease 2019 (COVID-19).Methods: Overall, 131 ...
Jingyuan Liu, Yuyong Jiang, Yao Liu, Lin Pu, Chunjing Du, Yuxin Li, Xiaojing Wang, Jie Ren, Wei Liu, Zhiyun Yang, Zhihai Chen, Rui Song, Wen Xie, Xianbo Wang   +13 more
doaj   +1 more source

Severe COVID-19 infection in a kidney transplant recipient treated with lopinavir/ritonavir, hydroxychloroquine and dexamethasone

Journal of Infection in Developing Countries, 2021
Severe COVID-19 infection management for a recipient of kidney transplant has debatable prognosis and treatment. We described the case of a COVID-19 infected 70 year old female, previously had renal transplantation in 2017.
Satriyo Dwi Suryantoro, Mochammad Thaha, Pranawa, Djoko Santoso, Nunuk Mardiana, Widodo, Aditiawardana, Artaria Tjempakasari, Ardityo Rahmat Ardhany, Dana Pramudya, Decsa Medika Hertanto, Evy Febriane, Meryana, Maria Angela, Ari Christy Muliono, Handoko Tanuwidjaja, Philia Setiawan, David Sugiarto   +17 more
doaj   +1 more source

Population pharmacokinetics of lopinavir/ritonavir in Covid-19 patients [PDF]

, 2021
International audienceObjective: To develop a population pharmacokinetic model for lopinavir boosted by ritonavir in coronavirus disease 2019 (Covid-19) patients.Methods: Concentrations of lopinavir/ritonavir were assayed by an accredited LC-MS/MS method.
Etting, Isabelle, Alvarez, Jean, Claude, Annane, Djillali, Larabi, Islam Amine, Simon, Nicolas, Moine, Pierre, Davido, Benjamin   +6 more
core   +1 more source

FACTORS INFLUENCING PLACENTAL TRANSFER OF LOPINAVIR: BINDING, UPTAKE AND EFFLUX [PDF]

, 2009
HIV protease inhibitors are an important component of Highly Active Antiretroviral Therapy used to treat HIV infected pregnant women. They have a low placental transfer and are highly plasma protein bound.
Gulati, Abhishek
core   +2 more sources

Improved Oral Bioavailability of Lopinavir in Melt-Extruded Tablet Formulation Reduces Impact of Third Trimester on Lopinavir Plasma Concentrations [PDF]

, 2012
Lopinavir exposure was reduced during the third trimester in pregnant women receiving standard dosing of the soft-gel capsule (SGC; 400/100 mg twice daily [b.i.d.]). Pharmacokinetic data on the lopinavir tablet in pregnancy are limited.
L. Dickinson, S. H. Khoo, L. J. Else, M. Douglas, G. P. Taylor, D. J. Back   +5 more
core   +1 more source

Clinical impact of double protease inhibitor boosting with Lopinavir/Ritonavir and Amprenavir as part of salvage antiretroviral therapy [PDF]

, 2003
Purpose: Double protease inhibitor (PI) boosting is being explored as a new strategy in salvage antiretroviral (ARV) therapy. However, if a negative drug interaction leads to decreased drug levels of either or both PIs, double PI boosting could lead to ...
Gough, K., Walmsley, S., Raboud, J., Tseng, A., Phillips, E., Rubin, G., Thompson, C., Abdurrahman, Z., Loutfy, M., Kovacs, C., Rachlis, A.   +10 more
core   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

The Plasma, Whole Blood and Intracellular Concentrations of Antiretroviral Agents in South African Children Receiving Combination Antiretroviral Therapy with and without Concomitant Antitubercular Treatment [PDF]

, 2009
Background: Tuberculosis (TB) is the most common opportunistic infection in children with human immunodeficiency virus (HIV) infection in developing countries, and co-treatment for HIV infection and TB is frequently indicated.
Ren, Yuan
core  

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Clinical and Immunological Outcomes after Initiation of Second Line Antiretroviral Therapy in People Living with HIV [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Resistance to first-line Antiretroviral Therapy (ART) has been a major concern in People Living with HIV (PLHIV), which necessitates a switch to second-line therapy.
BASAVAPRABHU ACHAPPA, DEEPAK MADI, MOHAMMAD YOUSUFF, SATISH RAO, JOHN RAMAPURAM   +4 more
doaj   +1 more source