Gamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1,4 butanediol (1,4-BD; BDO) : a literature review with a focus on UK fatalities related to non-medical use [PDF]
, 2015 Misuse of gamma hydroxybutrate (GHB) and gamma butyrolactone (GBL) has increased greatly since the early 1990s, being implicated in a rising number of deaths.
Abanades +324 more
core +1 more source
Clinical characteristics of a large cohort of patients with narcolepsy candidate for pitolisant: a cross-sectional study from the Italian PASS Wakix® Cohort [PDF]
, 2022 Introduction: Narcolepsy is a chronic and rare hypersomnia of central origin characterized by excessive daytime sleepiness and a complex array of symptoms as well as by several medical comorbidities.
Agostoni E. C. +28 more
core +5 more sources
Medical treatment of dystonia [PDF]
, 2016 Therapeutic strategies in dystonia have evolved considerably in the past few decades. Three major treatment modalities include oral medications, botulinum toxin injections and surgical therapies, particularly deep brain stimulation.
Pichet Termsarasab +2 more
core +2 more sources
Pain-related diseases and sleep disorders [PDF]
, 2012 Pain and sleep share mutual relations under the influence of cognitive and neuroendocrine changes. Sleep is an important homeostatic feature and, when impaired, contributes to the development or worsening of pain-related diseases.
Roizenblatt, Marina +3 more
core +4 more sources
Why dried blood spots are an ideal tool for CYP1A2 phenotyping [PDF]
, 2014 Background and Objective: Dried blood spot (DBS) sampling has gained wide interest in bioanalysis during the last decade and has already been successfully applied in pharmacokinetic and phenotyping studies.
De Kesel, Pieter +2 more
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Autonomic Dysfunction in Hypersomnia [PDF]
, 2023 Purpose of Review: This article provides a comprehensive overview of the literature on autonomic dysfunctions in centraldisorders of hypersomnolence: narcolepsy type 1 and type 2, idiopathic hypersomnia, and the Kleine-Levin syndrome.
Alessandro Silvani +4 more
core +1 more source
Treatments for enhancing sleep quality in fibromyalgia: a systematic review and meta-analysis. [PDF]
Rheumatology (Oxford)OBJECTIVES: Sleep disturbance is a key symptom of fibromyalgia and a risk factor for chronic widespread pain. This systematic review and meta-analysis aims to assess the effectiveness of pharmacological treatments and cognitive behavioural therapy (CBT ...
Pathak A +8 more
europepmc +6 more sources
Treatment of Essential Tremor: Are there Issues We are Overlooking? [PDF]
, 2012 Background: Essential tremor (ET) is one of the most common neurological diseases. Although a large number of medications have been tested, there are only two first-line medications, primidone and propranolol, which is a situation that has not changed in
Elan D. Louis
core +1 more source
Fibromyalgia syndrome: an overview of pathophysiology, diagnosis and management [PDF]
, 2012 Fibromyalgia Syndrome (FMS) is a chronic condition causing pain, stiffness, and tenderness of the muscles, tendons, and joints. It is also characterized by restless sleep, tiredness, fatigue, anxiety, depression, and disturbances in bowel functions.
Jahan, Firdous +3 more
core +2 more sources
Nature and Science of Sleep, 2023 Logan Douglas Schneider,1 Joanne Stevens,2 Aatif M Husain,3 Diane Ito,4 Douglas S Fuller,5 Phyllis C Zee,6 Wayne Macfadden2 1Stanford University Sleep Medicine Center, Stanford University School of Medicine, Stanford, CA, USA; 2Global Medical Affairs ...
Schneider LD +6 more
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