Results 61 to 70 of about 33,152 (158)

Role of Matrix Metalloproteinases in HaCaT Keratinocytes Apoptosis Induced by Loxosceles Venom Sphingomyelinase D [PDF]

, 2006
Envenomation by the spider Loxosceles (brown spider) can result in dermonecrosis and severe ulceration. We have previously shown that Loxosceles sphingomyelinase D (SMaseD), the enzyme responsible for these pathological effects, induced expression of ...
de Freitas Fernandes-Pedrosa, Matheus, Tambourgi, Denise V., Rute M. Gonçalves de Andrade, Danielle Paixão-Cavalcante, Denise V. Tambourgi, Paixão-Cavalcante, Danielle, Gonçalves de Andrade, Rute M., Matheus de Freitas Fernandes-Pedrosa, Carmen W. van den Berg, van den Berg, Carmen W.   +9 more
core   +1 more source

Genome-wide identification, structural homology analysis, and evolutionary diversification of the phospholipase D gene family in the venom gland of three scorpion species

BMC Genomics, 2023
Background Venom phospholipase D (PLDs), dermonecrotic toxins like, are the major molecules in the crude venom of scorpions, which are mainly responsible for lethality and dermonecrotic lesions during scorpion envenoming.
Masoumeh Baradaran, Fatemeh Salabi
doaj   +1 more source

Specific immunotherapy in Albanian patients with anaphylaxis to hymenoptera venoms [PDF]

, 2002
Background: Severe allergic reactions during rush-specific immunotherapy (Rush-SIT) may occur in the treatment of hymenoptera sting allergy. The objective of the present study was to examine the characteristics of allergic reactions during Rush-SIT in a ...
Mingomataj, Ervin, Fischer, Axel, Qirko, Etleva, Peiser, Christian, Groneberg, Jan David Alexander, Priftanji, Alfred, Dinh, Q. Thai   +6 more
core   +1 more source

Insects as biological models to assay spider and scorpion venom toxicity

Journal of Venomous Animals and Toxins including Tropical Diseases, 2003
This study was undertaken to develop an experimental protocol using insects as biological models to assay venom toxicity of the following spiders Loxosceles gaucho, Phoneutria nigriventer, Nephilengys cruentata and Tityus serrulatus scorpion.
M. F. Manzoli-Palma, N. Gobbi, M. S. Palma   +2 more
doaj   +1 more source

Brown Recluse spider bite mediated hemolysis: clinical features, a possible role for complement inhibitor therapy, and reduced RBC surface glycophorin A as a potential biomarker of venom exposure. [PDF]

PLoS ONE, 2013
The venom of Loxosceles reclusa (Brown Recluse spider) can cause a severe, life-threatening hemolysis in humans for which no therapy is currently available in the USA beyond supportive measures.
Eric A Gehrie, Hui Nian, Pampee P Young
doaj   +1 more source

Presença de Loxosceles similis Moenkhaus, 1898 (Araneae, Sicariidae) na Serra da Bodoquena, Estado de Mato Grosso do Sul, Brasil Presence of Loxosceles similis Moenkhaus, 1898 (Araneae, Sicariidae) in Bodoquena Range, State of Mato Grosso do Sul, Brazil

Revista da Sociedade Brasileira de Medicina Tropical, 2001
O veneno das aranhas do gênero Loxosceles causa lesão dermonecrótica e induz hemólise intravascular dependente de complemento, configurando um quadro clínico de intensa gravidade. No Brasil, as espécies L. gaucho L. intermedia e L.
Rute Maria Gonçalves de Andrade, Eunice Aparecida Bianchi Galati, Denise Vilarinho Tambourgi   +2 more
doaj   +1 more source

Loxoscelism: Advances and Challenges in the Design of Antibody Fragments with Therapeutic Potential

Toxins, 2020
Envenoming due to Loxosceles spider bites still remains a neglected disease of particular medical concern in the Americas. To date, there is no consensus for the treatment of envenomed patients, yet horse polyclonal antivenoms are usually infused to ...
Sabrina Karim-Silva, Alessandra Becker-Finco, Isabella Gizzi Jiacomini, Fanny Boursin, Arnaud Leroy, Magali Noiray, Juliana de Moura, Nicolas Aubrey, Philippe Billiald, Larissa M. Alvarenga   +9 more
doaj   +1 more source

A novel hyaluronidase from brown spider (Loxosceles intermedia) venom (Dietrich's Hyaluronidase): from cloning to functional characterization. [PDF]

PLoS Neglected Tropical Diseases, 2013
Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. The venom contains several enzymatic toxins.
Valéria Pereira Ferrer, Thiago Lopes de Mari, Luiza Helena Gremski, Dilza Trevisan Silva, Rafael Bertoni da Silveira, Waldemiro Gremski, Olga Meiri Chaim, Andrea Senff-Ribeiro, Helena Bonciani Nader, Silvio Sanches Veiga   +9 more
doaj   +1 more source

Venomics of the six-eyed sand spider, Sicarius rugosus (Araneae: Sicariidae), from the neotropical dry forest of Costa Rica

Journal of Basic and Applied Zoology
Background Sicarius rugosus, the only member of the genus that inhabits Central America, is phylogenetically related to South American Sicarius spiders. These originated from a common ancestor with sister African species.
Cecilia Díaz, Fabián Bonilla, Julián Fernández, Mahmood Sasa   +3 more
doaj   +1 more source

The History of Venomous Spider Identification, Venom Extraction Methods and Antivenom Production: a Long Journey at the Butantan Institute, São Paulo, Brazil

Journal of Venomous Animals and Toxins including Tropical Diseases, 2015
The article provides a historical report on venomous spider identification, venom obtainment methods and serum production at the Butantan Institute, São Paulo, Brazil. It is based on literature and personnal experience during the last 50 years.
Sylvia M Lucas
doaj   +1 more source