Results 1 to 10 of about 13,482,017 (199)

Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation [PDF]

Toxins, 2015
Sphingolipids are major constituents of biological membranes of eukaryotic cells. Many studies have shown that sphingomyelin (SM) is a major phospholipid in cell bilayers and is mainly localized to the plasma membrane of cells, where it serves both as a
Io-Guané Rivera, Marta Ordoñez, Natalia Presa, Ana Gomez-Larrauri, Jorge Simón, Miguel Trueba, Antonio Gomez-Muñoz   +6 more
doaj   +8 more sources

Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate. [PDF]

PLoS ONE, 2012
The toxicity of Loxosceles spider venom has been attributed to a rare enzyme, sphingomyelinase D, which transforms sphingomyelin to ceramide-1-phosphate. The bases of its inflammatory and dermonecrotic activity, however, remain unclear.
Roberto P Stock, Jonathan Brewer, Kerstin Wagner, Blanca Ramos-Cerrillo, Lars Duelund, Kit Drescher Jernshøj, Lars Folke Olsen, Luis A Bagatolli   +7 more
doaj   +9 more sources

Digestive enzymes and sphingomyelinase D in spiders without venom (Uloboridae) [PDF]

Scientific Reports, 2023
Spiders have distinct predatory behaviours selected along Araneae’s evolutionary history but are mainly based on the use of venom for prey paralysis. Uloboridae spiders have lost their venom glands secondarily during evolution.
Rodrigo Valladão, Oscar Bento Silva Neto, Marcelo de Oliveira Gonzaga, Daniel Carvalho Pimenta, Adriana Rios Lopes   +4 more
doaj   +4 more sources

Sphingomyelinase D Activity in Sicarius tropicus Venom: Toxic Potential and Clues to the Evolution of SMases D in the Sicariidae Family [PDF]

Toxins, 2021
The spider family Sicariidae includes three genera, Hexophthalma, Sicarius and Loxosceles. The three genera share a common characteristic in their venoms: the presence of Sphingomyelinases D (SMase D).
Priscila Hess Lopes, Caroline Sayuri Fukushima, Rosana Shoji, Rogério Bertani, Denise V. Tambourgi   +4 more
doaj   +6 more sources

Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Loxosceles spiders’ venoms consist of a mixture of proteins, including the sphingomyelinases D (SMases D), which are the main toxic components responsible for local and systemic effects in human envenomation.
Priscila Hess Lopes, Mário T. Murakami, Fernanda C. V. Portaro, Kerly Fernanda Mesquita Pasqualoto, Carmen van den Berg, Denise V. Tambourgi   +5 more
doaj   +5 more sources

Sphingomyelinase D from Loxosceles laeta Venom Induces the Expression of MMP7 in Human Keratinocytes: Contribution to Dermonecrosis. [PDF]

PLoS ONE, 2016
Envenomation by Loxosceles spider is characterized by the development of dermonecrosis. In previous studies, we have demonstrated that increased expression/secretion of matrix metalloproteinases 2 and 9, induced by Loxosceles intermedia venom Class 2 ...
Mara A Corrêa, Cinthya K Okamoto, Rute M Gonçalves-de-Andrade, Carmen W van den Berg, Denise V Tambourgi   +4 more
doaj   +5 more sources

Acid Sphingomyelinase Activity in Dried Blood Spot from Neonatal Intensive Care Unit–Admitted Neonates: A Pilot Study for Expanded Newborn Screening in Japan [PDF]

International Journal of Neonatal Screening
Acid sphingomyelinase deficiency (ASMD) is currently treatable with olipudase alfa, increasing the need for early newborn screening (NBS). We conducted a two-center pilot cohort study to characterize dried blood spot (DBS) acid sphingomyelinase (ASM ...
Akie Kato, Atsuko Noguchi, Hiroyuki Adachi, Kiichi Takahashi, Masato Ito, Tomoo Ito, Shozo Ota, Hirokazu Arai   +7 more
doaj   +2 more sources

GW4869 Depletes Macrophages and Increases Number of Extracellular Vesicles in Murine Peritoneal Cavity Fluid. [PDF]

J Extracell Biol
ABSTRACT Pharmacological strategies to modulate extracellular vesicle (EV) release in vivo are gaining traction, yet their broader effects on local immune microenvironments remain unclear. In this study, we assessed how repeated intraperitoneal (i.p.) dosing of the neutral sphingomyelinase inhibitor GW4869 reshapes the peritoneal cavity.
Gudbergsson JM, Gobira PH, Grassi-Oliveira R, Etzerodt A.   +3 more
europepmc   +2 more sources

Metabolic improvement in patients with acid sphingomyelinase deficiency following intravenous trehalose administration: an untargeted pharmacometabolomic study [PDF]

Orphanet Journal of Rare Diseases
Background Acid sphingomyelinase deficiency (ASMD) A and B, historically known as Niemann-Pick (NP) types A (NPA) and B (NPB), are life-threatening and rare inherited lysosomal storage disorders, caused by a deficiency in the acid sphingomyelinase enzyme
Mahdieh Khoshakhlagh, Maede Hasanpour, Mehrdad Iranshahi, Javad Asili, Aida Tasbandi, Tannaz Jamialahmadi, Amirhossein Sahebkar, Milad Iranshahy   +7 more
doaj   +2 more sources

Venom of the Brazilian spider Sicarius ornatus (Araneae, Sicariidae) contains active sphingomyelinase D: potential for toxicity after envenomation. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND:The spider family Sicariidae includes two genera, Sicarius and Loxosceles. Bites by Sicarius are uncommon in humans and, in Brazil, a single report is known of a 17-year old man bitten by a Sicarius species that developed a necrotic lesion ...
Priscila Hess Lopes, Rogério Bertani, Rute M Gonçalves-de-Andrade, Roberto H Nagahama, Carmen W van den Berg, Denise V Tambourgi   +5 more
doaj   +2 more sources