Results 21 to 30 of about 13,482,017 (199)

Plasma Membrane Repair Is Regulated Extracellularly by Proteases Released from Lysosomes. [PDF]

PLoS ONE, 2016
Eukaryotic cells rapidly repair wounds on their plasma membrane. Resealing is Ca(2+)-dependent, and involves exocytosis of lysosomes followed by massive endocytosis.
Thiago Castro-Gomes, Matthias Corrotte, Christina Tam, Norma W Andrews   +3 more
doaj   +1 more source

Analysis of High Molecular Mass Compounds from the Spider Pamphobeteus verdolaga Venom Gland. A Transcriptomic and MS ID Approach

Toxins, 2021
Nowadays, spider venom research focuses on the neurotoxic activity of small peptides. In this study, we investigated high-molecular-mass compounds that have either enzymatic activity or housekeeping functions present in either the venom gland or venom of
Sebastian Estrada-Gómez, Leidy Johana Vargas-Muñoz, Cesar Segura Latorre, Monica Maria Saldarriaga-Cordoba, Claudia Marcela Arenas-Gómez   +4 more
doaj   +1 more source

Structure-based virtual screening to predict Loxosceles spider venom natural inhibitors

Digital Chinese Medicine, 2023
Objective: Loxosceles spider bite accidents are rising in wide areas of the world which necessitates the exploration of natural inhibitors to inhibit the most significant enzymes, namely sphingomyelinase D (Smase D) and hyaluronidase.
Haitham Ahmed Al-Madhagi
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Loxoscelism: Advances and Challenges in the Design of Antibody Fragments with Therapeutic Potential

Toxins, 2020
Envenoming due to Loxosceles spider bites still remains a neglected disease of particular medical concern in the Americas. To date, there is no consensus for the treatment of envenomed patients, yet horse polyclonal antivenoms are usually infused to ...
Sabrina Karim-Silva, Alessandra Becker-Finco, Isabella Gizzi Jiacomini, Fanny Boursin, Arnaud Leroy, Magali Noiray, Juliana de Moura, Nicolas Aubrey, Philippe Billiald, Larissa M. Alvarenga   +9 more
doaj   +1 more source

Structural Basis for Metal Ion Coordination and the Catalytic Mechanism of Sphingomyelinases D [PDF]

Journal of Biological Chemistry, 2005
Sphingomyelinases D (SMases D) from Loxosceles spider venom are the principal toxins responsible for the manifestation of dermonecrosis, intravascular hemolysis, and acute renal failure, which can result in death. These enzymes catalyze the hydrolysis of sphingomyelin, resulting in the formation of ceramide 1-phosphate and choline or the hydrolysis of ...
Murakami, M. T., Fernandes-Pedrosa, M. F., Tambourgi, D. V., Arni, R. K.   +3 more
openaire   +3 more sources

Biotechnological potential of Phospholipase D for Loxosceles antivenom development

Toxicon: X, 2020
Loxoscelism is one of the most important forms of araneism in South America. The Health Authorities from countries with the highest incidence and longer history in registering loxoscelism cases indicate that specific antivenom should be administered ...
Matías Fingermann, Adolfo Rafael de Roodt, Osvaldo Cascone, María Victoria Miranda   +3 more
doaj   +1 more source

Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties [PDF]

, 2015
This work was supported by National Institute of Mental Health grants: P30 MH075673-06 to BSS, CR, NJH and JCM; R01 MH096636 and R01 MH077542 to NJH (http://projectreporter.nih.gov/reporter.​cfm); and The Johns Hopkins Brain Science Institute to BSS ...
Justin C. McArthur (66539), Bandaru, Veera Venkata Ratnam, Graeme W. Rogers (744791), Yoo, Seung-Wan, Seung-Wan Yoo (744790), McArthur, Justin C., Justin C McArthur, Veera Venkata Ratnam Bandaru (193990), Haughey, Norman J., Marigo Stathis, Graeme W Rogers, Figuera-Losada, Mariana, Veera Venkata Ratnam Bandaru, Stathis, Marigo, Norman J Haughey, Slusher, Barbara S., Barbara S Slusher, Barbara S. Slusher (634276), Joelle M Dorskind, Nicholas J Westwood, Seung-Wan Yoo, Norman J. Haughey (193998), Mariana Figuera-Losada (744786), Marigo Stathis (744787), Camilo Rojas (744792), Ajit G. Thomas (744789), Westwood, Nicholas James, Rojas, Camilo, Nicholas J. Westwood (254891), Thomas, Ajit G., Rogers, Graeme Wayne, Mariana Figuera-Losada, Joelle M. Dorskind (744788), Ajit G Thomas, Dorskind, Joelle M., Camilo Rojas   +35 more
core   +2 more sources

Niemann Pick disease: a rare lysosomal storage disease

Bangabandhu Sheikh Mujib Medical University Journal, 2023
Niemann Pick Disease (NPD) is a rare autosomal recessive lysosomal storage disease characterized by lysosomal lipid storage. The disease is caused by deficiency of enzyme, acid sphingomyelinase (ASM) which leads to accumulation of sphingomyelin & other ...
Gopen Kumar Kundu, Sk Serjina Anwar, Noor A Sabah Liza, Syeda Tabassum Alam, Sanjida Ahmed, Mohammad Arbab Sarker, Meher Nigar Nishi, Sharmina Afrin, Mohammad Abdul Quddus   +8 more
doaj   +1 more source

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]

, 2010
Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K., Young, Simon A., Young, Simon Alan   +2 more
core   +1 more source