Results 41 to 50 of about 13,482,017 (199)

Acid sphingomyelinase deficiency ameliorates Farber disease

, 2021
Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan.
Kleuser, Burkhard (Prof. Dr. rer. nat.), Beckmann, Nadine, Kühn, Claudine, Gulbins, Erich, Schulz-Schaeffer, Walter J., Carpinteiro, Alexander, Becker, Katrin Anne, Edwards, Michael J., Kramer, Melanie, Kadow, Stephanie, Schumacher, Fabian (Dr.)   +10 more
core   +1 more source

Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages

, 1991
Cholesteryl ester-loaded macrophages, or foam cells, are a prominent feature of atherosclerotic lesions. Low density lipoprotein (LDL) receptor-mediated endocytosis of native LDL is a relatively poor inducer of macrophage cholesteryl ester accumulation ...
Tabas, I, Xu, X X
core   +5 more sources

Sphingolipid and ceramide homeostasis : potential therapeutic targets [PDF]

, 2012
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction.
Smith, Terry, Simon A. Young, Denny, Paul, Young, Simon, Denny, Paul W., Mina, J.G., Mina, John, Denny, P.W., Smith, Terry K., Mina, John G., John G. Mina, Young, S.A., Smith, T.K., Paul W. Denny, Young, Simon A., Terry K. Smith   +15 more
core   +1 more source

Role of Matrix Metalloproteinases in HaCaT Keratinocytes Apoptosis Induced by Loxosceles Venom Sphingomyelinase D [PDF]

Journal of Investigative Dermatology, 2006
Envenomation by the spider Loxosceles (brown spider) can result in dermonecrosis and severe ulceration. We have previously shown that Loxosceles sphingomyelinase D (SMaseD), the enzyme responsible for these pathological effects, induced expression of matrix metalloproteinase-9 (MMP-9), which is possibly one of the main factors involved in the ...
Paixão-Cavalcante, Danielle, van den Berg, Carmen W., de Freitas Fernandes-Pedrosa, Matheus, Gonçalves de Andrade, Rute M., Tambourgi, Denise V.   +4 more
openaire   +2 more sources

Lipid levels in sperm, eggs, and during fertilization in Xenopus laevis

Journal of Lipid Research, 2008
Critical developmental periods, such as fertilization, involve metabolic activation, membrane fusion events such as sperm-egg or plasma membrane-cortical granule merger, and production and hydrolysis of phospholipids.
Douglas W. Petcoff, William L. Holland, Bradley J. Stith   +2 more
doaj   +1 more source

Identification of New Sphingomyelinases D in Pathogenic Fungi and Other Pathogenic Organisms

PLoS ONE, 2013
Sphingomyelinases D (SMases D) or dermonecrotic toxins are well characterized in Loxosceles spider venoms and have been described in some strains of pathogenic microorganisms, such as Corynebacterium sp. After spider bites, the SMase D molecules cause skin necrosis and occasional severe systemic manifestations, such as acute renal failure.
Camila Dias-Lopes, Izabella A P Neshich, Goran Neshich, José Miguel Ortega, Claude Granier, Carlos Chávez-Olortegui, Franck Molina, Liza Felicori   +7 more
openaire   +4 more sources

Tetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom

Toxins, 2017
Envenomation by Loxosceles spider can result in two clinical manifestations: cutaneous and systemic loxoscelism, the latter of which includes renal failure.
Cinthya Kimori Okamoto, Carmen W. van den Berg, Mizuno Masashi, Rute M. Gonçalves-de-Andrade, Denise V. Tambourgi   +4 more
doaj   +1 more source

Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice

Pharmaceutics, 2023
The progression of Alzheimer’s disease (AD) correlates with the propagation of hyperphosphorylated tau (pTau) from the entorhinal cortex to the hippocampus and neocortex.
Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D. J. Huizar, Silvia Picciolini, Ajit G. Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M. Kannan, Marzia Bedoni, Rana Rais, Barbara S. Slusher   +13 more
doaj   +1 more source

Sphingomyelinases D From Loxosceles Spider Venoms and Cell Membranes: Action on Lipid Rafts and Activation of Endogenous Metalloproteinases

Frontiers in Pharmacology, 2020
Loxosceles spider venom contains Sphingomyelinase D (SMase D), the key toxin causing pathology. SMase D hydrolyzes the main component of lipid rafts, sphingomyelin, which changes the membrane microenvironment resulting in the activation of endogenous ...
Priscila Hess Lopes, Carmen W. van den Berg, Denise V. Tambourgi   +2 more
doaj   +1 more source

Sphingomyelinase activity at pH 7.4 in human brain and a comparison to activity at pH 5.0

Journal of Lipid Research, 1976
A hitherto undescribed sphingomyelinase (sph'ase 7.4) of human brain has been studied in crude and partially purified (3- to 4- fold) extracts of grey matter, and compared to the known sphingomyelinase with an acid pH optimum (sph'ase 5.0).
B G Rao, Dr M W Spence
doaj   +1 more source