Results 31 to 40 of about 13,482,017 (199)

Staphylococcus aureus α-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides

Cellular Physiology and Biochemistry, 2017
Background/Aims: Staphylococcus aureus (S. aureus) infections are a major clinical problem and range from mild skin and soft-tissue infections to severe and even lethal infections such as pneumonia, endocarditis, sepsis, osteomyelitis, and toxic shock ...
Jie Ma, Erich Gulbins, Michael J. Edwards, Charles C. Caldwell, Martin Fraunholz, Katrin Anne Becker   +5 more
doaj   +1 more source

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure [PDF]

, 2012
Contains fulltext : 107961.pdf (Publisher’s version ) (Open Access)Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Dinkla, S., Brock, R.E., Dinkla, S, Cluitmans, JC, Fuchs, B, Joosten, I, Fransen, J., Tomelleri, C, Verdurmen, W.P.R., Bosman, G.J.C.G.M., Wessels, K, Schiller, J., Wessels, K., Brock, R, Fuchs, B., Verdurmen, WP, Joosten, I., Bosman, GJ, Cluitmans, J.C.A., Schiller, J, Tomelleri, C., Fransen, J   +21 more
core   +2 more sources

Acid Sphingomyelinase Deficiency Ameliorates Farber Disease [PDF]

, 2019
Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan.
Michael J. Edwards, Kleuser, Burkhard (Prof. Dr. rer. nat.), Walter J. Schulz-Schaeffer, Gulbins, Erich, Claudine Kühn, Kuehn, Claudine, Katrin Anne Becker, Fabian Schumacher, Becker, Katrin Anne, Edwards, Michael J., Kramer, Melanie, Melanie Kramer, Kadow, Stephanie, Stephanie Kadow, Burkhard Kleuser, Beckmann, Nadine, Nadine Beckmann, Schulz-Schaeffer, Walter J., Carpinteiro, Alexander, Alexander Carpinteiro, Schumacher, Fabian (Dr.), Erich Gulbins   +21 more
core   +2 more sources

Sphingomyelinase D inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current. [PDF]

J Gen Physiol, 2015
Infections caused by certain bacteria including Mycobacterium tuberculosis and Corynebacterium pseudotuberculosis provoke inflammatory responses characterized by the formation of granulomas with necrotic foci—so-called caseous necrosis. The granulomas of infected animals show prominent infiltration by T lymphocytes, and T cell depletion increases host ...
Combs DJ, Lu Z.
europepmc   +4 more sources

First report of in vitro selection of RNA aptamers targeted to recombinant Loxosceles laeta spider toxins

Biological Research, 2014
BACKGROUND: Loxoscelism is the envenomation caused by the bite of Loxosceles spp. spiders. It entails severe necrotizing skin lesions, sometimes accompanied by systemic reactions and even death.
Amalia Sapag, Catalina Salinas-Luypaert, Carlos Constenla-Muñoz   +2 more
doaj   +1 more source

Down-regulation of acid sphingomyelinase and neutral sphingomyelinase-2 inversely determines the cellular resistance to plasmalemmal injury by pore-forming toxins. [PDF]

, 2019
Bacterial pore-forming toxins compromise plasmalemmal integrity, leading to Ca2+ influx, leakage of the cytoplasm, and cell death. Such lesions can be repaired by microvesicular shedding or by the endocytic uptake of the injured membrane sites.
Roman Schoenauer, Patrick Drücker, Draeger, Annette, Yu Larpin, Eduard B. Babiychuk, Viktoriia S. Babiychuk, Schönauer, Roman, Elita Avota, Fabian Schumacher, Annette Draeger, Schneider-Schaulies, S, Schumacher, F, Avota, E, Drücker, Patrick, Burkhard Kleuser, Babiychuk, Eduard, Babiychuk, Victoria, Larpin, Yu-Noël, Sibylle Schneider-Schaulies, René Köffel, Köffel, René, Kleusner, B   +21 more
core   +1 more source

Recombinant Protein Containing B-Cell Epitopes of Different Loxosceles Spider Toxins Generates Neutralizing Antibodies in Immunized Rabbits

Frontiers in Immunology, 2018
Loxoscelism is the most important form of araneism in South America. The treatment of these accidents uses heterologous antivenoms obtained from immunization of production animals with crude loxoscelic venom.
Sabrina de Almeida Lima, Clara Guerra-Duarte, Fernanda Costal-Oliveira, Thais Melo Mendes, Luís F. M. Figueiredo, Daysiane Oliveira, Ricardo A. Machado de Avila, Valéria Pereira Ferrer, Dilza Trevisan-Silva, Silvio S. Veiga, João C. Minozzo, Evanguedes Kalapothakis, Carlos Chávez-Olórtegui   +12 more
doaj   +1 more source

Systemic Loxoscelism, Less Frequent but More Deadly: The Involvement of Phospholipases D in the Pathophysiology of Envenomation

Toxins, 2022
Bites of Loxosceles spiders can lead to a set of clinical manifestations called loxoscelism, and are considered a public health problem in many regions. The signs and symptoms of loxoscelism are divided into cutaneous and systemic forms.
Luiza Helena Gremski, Hanna Câmara da Justa, Nayanne Louise Costacurta Polli, Pedro Henrique de Caires Schluga, João Lucas Theodoro, Ana Carolina Martins Wille, Andrea Senff-Ribeiro, Silvio Sanches Veiga   +7 more
doaj   +1 more source

Spider and Bacterial Sphingomyelinases D Target Cellular Lysophosphatidic Acid Receptors by Hydrolyzing Lysophosphatidylcholine [PDF]

Journal of Biological Chemistry, 2004
Bites by Loxosceles spiders can produce severe clinical symptoms, including dermonecrosis, thrombosis, vascular leakage, hemolysis, and persistent inflammation. The causative factor is a sphingomyelinase D (SMaseD) that cleaves sphingomyelin into choline and ceramide 1-phosphate.
van Meeteren, Laurens A, Frederiks, Floor, Giepmans, Ben N G, Pedrosa, Matheus F Fernandes, Billington, Stephen J, Jost, B Helen, Tambourgi, Denise V, Moolenaar, Wouter H   +7 more
openaire   +2 more sources

Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice

Pharmaceutics, 2022
Alzheimer’s disease (AD) is characterized by the progressive accumulation of amyloid-β and hyperphosphorylated tau (pTau), which can spread throughout the brain via extracellular vesicles (EVs).
Carolyn Tallon, Benjamin J. Bell, Anjali Sharma, Arindom Pal, Medhinee M. Malvankar, Ajit G. Thomas, Seung-Wan Yoo, Kristen R. Hollinger, Kaleem Coleman, Elizabeth L. Wilkinson, Sujatha Kannan, Norman J. Haughey, Rangaramanujam M. Kannan, Rana Rais, Barbara S. Slusher   +14 more
doaj   +1 more source