Results 11 to 20 of about 13,482,017 (199)

Sphingomyelinase D, a novel probe for cellular sphingomyelin [PDF]

Journal of Lipid Research, 2003
Sphingomyelin (SM) and free cholesterol (FC) are concentrated in the plasma membranes of eukaryotes; however, the physiological significance of their association is unclear.
Papasani V. Subbaiah, Stephen J. Billington, B. Helen Jost, J. Glenn Songer, Yvonne Lange   +4 more
doaj   +2 more sources

Niemann-Pick Type A Disease: Behavior of Neutral Sphingomyelinase and Vitamin D Receptor [PDF]

International Journal of Molecular Sciences, 2019
Sphingomyelinase (SMase) is responsible for the breakdown of sphingomyelin (SM) with production of ceramide. The absence of acid sphingomyelinase (aSMase) causes abnormal synapse formation in Niemann-Pick type A (NPA) disease. Because high levels of ceramide in the NPA brain were demonstrated, the involvement of other SMases were supposed.
Conte, Carmela, Arcuri, Cataldo, Cataldi, Samuela, Mecca, Carmen, Codini, Michela, Ceccarini, Maria Rachele, Patria, Federica Filomena, Beccari, Tommaso, Albi, Elisabetta   +8 more
openaire   +4 more sources

A New Anti-loxoscelic Serum Produced Against Recombinant Sphingomyelinase D: Results of Preclinical Trials

The American Journal of Tropical Medicine and Hygiene, 2008
Envenomation by Loxosceles species (brown spider) can lead to local dermonecrosis and to serious systemic effects. The main toxic component in the venom of these spiders is sphingomyelinase D (SMase D) and various isoforms of this toxin are present in Loxosceles venoms.
Daniel Manzoni, de Almeida, Matheus de F, Fernandes-Pedrosa, Rute M Gonçalves, de Andrade, José Roberto, Marcelino, Hisako, Gondo-Higashi, Inácio de L M Junqueira, de Azevedo, Paulo Lee, Ho, Carmen, van den Berg, Denise V, Tambourgi   +8 more
core   +9 more sources

Podocyte-specific acid sphingomyelinase overexpression promotes gasdermin D dependent pyroptosis by impairing autophagic flux during obesity [PDF]

Frontiers in Physiology
Recent studies suggest that gasdermin D (GSDMD) pore formation contributes to inflammasome-mediated cytokine release and pyroptosis in podocytes under pathological conditions.
Dandan Huang, Yao Zou, Ethan Chan, Jason M. Kidd, Xiaoyuan Wu, Yang Zhang, Todd W.B. Gehr, Ningjun Li, Pin-Lan Li, Guangbi Li   +9 more
doaj   +2 more sources

Loxosceles venom Sphingomyelinase D activates human blood leukocytes: Role of the complement system

Molecular Immunology, 2018
Envenomation by Loxosceles spiders can result in severe systemic and local reactions, which are mainly triggered by Sphingomyelinase D (SMase D), a toxic component of Loxosceles venom. SMase D induces a systemic inflammatory condition similar to the reaction observed during an endotoxic shock.
Daniel, Manzoni-de-Almeida, Carla Cristina, Squaiella-Baptistão, Priscila Hess, Lopes, Carmen W, van den Berg, Denise V, Tambourgi   +4 more
openaire   +3 more sources

Membrane structure and the activity of phospholipase and sphingomyelinase D [PDF]

Biophysical Journal, 2009
Lipid-modifying enzymes play a vital role in the regulation of lipids as mediators of cell function. One example is the hydrolysis of phospholipids through phospholipase D (PLD), which produces the signalling molecule phosphatidic acid (PA). These processes at lipid membranes can be observed in situ through the application of different biophysical ...
Wagner, Kerstin, Brezesinski, Gerald, Stock, Roberto, Bagatolli, Luis   +3 more
  +8 more sources

Cathepsin D targeted by acid sphingomyelinase‐derived ceramide [PDF]

The EMBO Journal, 1999
Ceramide has been recognized as a common intracellular second messenger for various cytokines, growth factors and other stimuli, such as CD95, chemotherapeutic drugs and stress factors. To understand the role of ceramide during apoptosis and other cellular responses, it is critically important to characterize direct targets of ceramide action.
M, Heinrich, M, Wickel, W, Schneider-Brachert, C, Sandberg, J, Gahr, R, Schwandner, T, Weber, P, Saftig, C, Peters, J, Brunner, M, Krönke, S, Schütze   +11 more
openaire   +3 more sources

Sphingomyelinase-responsive nanomicelles for targeting atherosclerosis [PDF]

, 2023
Atherosclerosis, a leading cause of cardiovascular diseases requires approaches to enhance disease monitoring and treatment. Nanoparticles offer promising potential in this area by being customisable to target components or molecular processes within ...
Jesús, Ruiz-Cabello, Fernando, Herranz, María, Muñoz-Hernando, Paula, Nogales, Jacob F., Bentzon, Irene, Fernández-Barahona   +5 more
core   +1 more source

Saposin D: A sphingomyelinase activator [PDF]

Biochemical and Biophysical Research Communications, 1988
Saposin D, a newly discovered heat-stable, 10 kDa glycoprotein, was isolated from Gaucher spleen and purified to homogeneity. Chemical sequencing from its amino terminus demonstrated colinearity between its amino acid sequence and the deduced amino acid sequence of the fourth domain of prosaposin, the precursor of saposin proteins.
Morimoto, Satoshi, Martin, Brian M., Kishimoto, Yasuo, O'Brien, John S.   +3 more
openaire   +3 more sources

Crystallization and preliminary X-ray diffraction analysis of a novel sphingomyelinase D fromLoxosceles gauchovenom [PDF]

Acta Crystallographica Section F, Structural Biology Communications, 2014
Ricardo Mariutti, Mario T Murakami, Monika A Coronado   +2 more
exaly   +2 more sources