Results 91 to 100 of about 113,253 (324)
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.
PLoS ONE, 2011 Lysophosphatidic acid (LPA), a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA(1-6), showing both overlapping and distinct ...
Maikel Jongsma +4 more
doaj +1 more source
Cells, 2020 The pathogenesis of psoriasis, an immune-mediated chronic skin barrier disease, is not fully understood yet. Here, we identified lysophosphatidic acid (LPA) receptor 5 (LPA5)-mediated signaling as a novel pathogenic factor in psoriasis using an imiquimod-
Bhakta Prasad Gaire +5 more
doaj +1 more source
Mediators of Inflammation, 2022 Lysophosphatidic acid (LPA) has disruptive effects on lumbar spinal stenosis (LSS). Recently, LPA has been reported to be involved in spinal cord neuronal injury and toxicity, promoting the pathogenesis of LSS. However, the exact effects of LPA on spinal
Yifan Yang +6 more
doaj +1 more source
Ductaler Abgang der LPA – erfolgreiche Rekrutierung der LPA durch 2-Stufenkonzept
, 2015 Der ductale Abgang einer Pulmonalarterie führt nach neonatalem Verschluss des Ductus zu einer fehlenden Perfusion der betreffenden Pulmonalarterie. Bei Kindern ohne zusätzliche kardiovaskuläre Fehlbildungen (z.B. Fallout Tetralogie, VSD) bleibt dies klinisch meist unbemerkt, die Patienten[for full text, please go to the a.m. URL]
Wiegand, G +4 more
openaire +1 more source
Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA‐binding proteins in activation of LPA receptors [PDF]
FEBS Letters, 2002 Lysophosphatidic acid (LPA) exerts multiple biological functions through G protein‐coupled receptors (EDG2/LPA1, EDG4/LPA2, and EDG7/LPA3) and is present in serum where it is associated with albumin. In this study we examined LPA activity in various biological fluids by measuring the LPA‐induced increase in the intracellular concentration of calcium ...
Hama, Kotaro +4 more
openaire +2 more sources
Frontiers in Physiology, 2014 In vascular smooth muscle cells (VSMC) increased integrin adhesion to extracellular matrix (ECM) proteins, as well as the production of reactive oxygen species (ROS) are strongly stimulated by lysophosphatidic acid (LPA). We hypothesized that LPA-induced
Marius C. Staiculescu +12 more
doaj +1 more source
Fluid Communities: A Competitive, Scalable and Diverse Community Detection Algorithm
, 2017 We introduce a community detection algorithm (Fluid Communities) based on the idea of fluids interacting in an environment, expanding and contracting as a result of that interaction.
Ayguadé, Eduard +7 more
core +1 more source
Lysophosphatidic acid (LPA) and angiogenesis [PDF]
Angiogenesis, 2008 Lysophosphatidic acid (LPA) is a simple lipid with many important biological functions such as the regulation of cellular proliferation, cellular migration, differentiation, and suppression of apoptosis. Although a direct angiogenic effect of LPA has not been reported to date, there are indications that LPA promotes angiogenesis.
Carol M, Rivera-Lopez +2 more
openaire +2 more sources
Journal of Neuroinflammation, 2016 BackgroundMicroglia, the immunocompetent cells of the CNS, rapidly respond to brain injury and disease by altering their morphology and phenotype to adopt an activated state. Microglia can exist broadly between two different states, namely the classical (
I. Plastira +13 more
semanticscholar +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi +6 more
wiley +1 more source