Results 91 to 100 of about 12,929 (212)
Regulatory and retrograde signaling networks in the chlorophyll biosynthetic pathway
Journal of Integrative Plant Biology, Volume 67, Issue 4, Page 887-911, April 2025.This review summarizes the regulatory mechanisms that underlie chlorophyll synthesis, including (1) factors that control the activity and stability of tetrapyrrole biosynthesis enzymes, (2) transcriptional and post‐translational regulation of the tetrapyrrole biosynthesis pathway, and (3) the complex roles of tetrapyrrole‐mediated retrograde signaling ...
Yuhong Li +6 more
wiley +1 more source
LSD1 is required for chromosome segregation during mitosis
European Journal of Cell Biology, 2010 Dynamic methylation/demethylation of histones and non-histone proteins occurs during the cell cycle. Lysine-specific demethylase 1 (LSD1) exhibits diverse transcriptional activities through catalyzing demethylation of mono- and di-methylated histone H3 on lysine 4 (H3K4) and lysine 9 (H3K9).
Wenjuan Bu +8 more
openaire +3 more sources
The deubiquitinase USP38 affects cellular functions through interacting with LSD1
Biological Research, 2018 Background Deubiquitination is a posttranslational protein modification prevalent in mammalian cells. Deubiquitinases regulate the functions of the target protein by removing its ubiquitin chain.
Wenbin Liu +3 more
doaj +1 more source
iScienceSummary: Tissue development, homeostasis, and repair all require efficient progenitor expansion. Lysine-specific demethylase 1 (Lsd1) maintains plastic epigenetic states to promote progenitor proliferation while overexpressed Lsd1 protein causes ...
Chun Ting Lin +4 more
doaj
TERRA-LSD1 phase separation promotes R-loop formation for telomere maintenance in ALT cancer cells
Nature CommunicationsThe telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed DNA synthesis in the alternative lengthening of telomere (ALT) pathway.
Meng Xu +15 more
doaj +1 more source
Cell Reports, 2018 Summary: Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid leukemia (AML) with MLL translocations. The assumption has been that differentiation is induced through blockade of LSD1’s histone demethylase activity ...
Alba Maiques-Diaz +16 more
doaj
The Role of Programmed Cell Death Regulator LSD1 in Nematode-Induced Syncytium Formation
Frontiers in Plant Science, 2018 Cyst-forming plant-parasitic nematodes are common pests of many crops. They inject secretions into host cells to induce the developmental and metabolic reprogramming that leads to the formation of a syncytium, which is the sole food source for growing ...
Mateusz Matuszkiewicz +5 more
doaj +1 more source
Prob-cGAN: A Probabilistic Conditional Generative Adversarial Network for LSD1 Inhibitor Activity Prediction [PDF]
arXivThe inhibition of Lysine-Specific Histone Demethylase 1 (LSD1) is a promising strategy for cancer treatment and targeting epigenetic mechanisms. This paper introduces a Probabilistic Conditional Generative Adversarial Network (Prob-cGAN), designed to predict the activity of LSD1 inhibitors.
arxiv
The Disease Resistance Signaling Components EDS1 and PAD4 Are Essential Regulators of the Cell Death Pathway Controlled by LSD1 in Arabidopsis [PDF]
, 2001 Christine Rustérucci +4 more
openalex +1 more source
LSD1 inhibitors disrupt the GFI1 transcription repressor complex
Molecular & Cellular Oncology, 2018 Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1 ...
Alba Maiques-Diaz +3 more
doaj +1 more source