Results 41 to 50 of about 27,519 (289)
LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice [PDF]
, 2015 Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce the resumption of meiosis I and progression to meiosis II.
Chen, T +8 more
core +1 more source
LSD1 protects against hippocampal and cortical neurodegeneration [PDF]
Nature Communications, 2017 AbstractTo investigate the mechanisms that maintain differentiated cells, here we inducibly delete the histone demethylase LSD1/KDM1A in adult mice. Loss of LSD1 leads to paralysis, along with widespread hippocampus and cortex neurodegeneration, and learning and memory defects.
Michael A. Christopher +8 more
openalex +4 more sources
Effect of LSD1 on Proliferation and Metastasis of Ovarian Cancer Cells by Regulating Foxo3a
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the effects of lysine-specific demethylation 1 (LSD1) on the proliferation and metastasis of ovarian cancer cells by regulating Foxo3a.
WANG Pinhao +4 more
doaj +1 more source
Cells, 2021 Salicylic acid (SA) is well known hormonal molecule involved in cell death regulation. In response to a broad range of environmental factors (e.g., high light, UV, pathogens attack), plants accumulate SA, which participates in cell death induction and ...
Maciej Jerzy Bernacki +3 more
doaj +1 more source
Science-Business eXchange, 2012 Two teams have independently provided preclinical proof of concept for using lysine-specific histone demethylase 1 inhibitors to treat acute myelogenous leukemia. One of the teams is now running a clinical trial of a generic monoamine oxidase inhibitor that counts the demethylase among its many targets, whereas at least four biotechs are advancing ...
openaire +1 more source
The histone demethylase LSD1/KDM1A promotes the DNA damage response [PDF]
, 2013 Histone demethylation is known to regulate transcription, but its role in other processes is largely unknown. We report a role for the histone demethylase LSD1/KDM1A in the DNA damage response (DDR).
Acs +84 more
core +2 more sources
Cells, 2023 Hepatitis C virus (HCV) alters gene expression epigenetically to rearrange the cellular microenvironment in a beneficial way for its life cycle. The host epigenetic changes induced by HCV lead to metabolic dysfunction and malignant transformation. Lysine-
Georgia Papadopoulou +9 more
doaj +1 more source
Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]
, 2018 Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang +16 more
core +2 more sources
Cancer Research, 2023 The lysine demethylase LSD1 (also called KDM1A) plays important roles in promoting multiple malignancies including both hematologic cancers and solid tumors.
Muqing Li +11 more
semanticscholar +1 more source
Gene regulation and epigenotype in Friedreich's ataxia [PDF]
, 2008 Friedreich??????s ataxia (FRDA) is known to be provoked by an abnormal GAA-repeat expansion located in the first intron of the FXN gene. As a result of the GAA expansion, patients exhibit low levels of FXN mRNA, leading to FRDA.
Rothe, Nadine, Rothe, Nadine
core +2 more sources