Results 71 to 80 of about 12,929 (212)

LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer

Clinical Epigenetics, 2017
Background Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a
Sebastiano Battaglia, Ellen Karasik, Bryan Gillard, Jennifer Williams, Trisha Winchester, Michael T. Moser, Dominic J Smiraglia, Barbara A. Foster   +7 more
doaj   +1 more source

LTF as a Potential Predictive Biomarker for Durable Benefit From First‐Line Chemo‐Immunotherapy in Small Cell Lung Cancer

Cancer Science, EarlyView.
LTF as a potential biomarker for predicting the efficacy of chemo‐immunotherapy. ABSTRACT At present, only a limited fraction of patients with extensive‐stage small cell lung cancer (ES‐SCLC) achieve a sustained response to immune checkpoint blockade (ICB) therapy.
Shimo Shen, Yili Wu, Zhuowei Shao, You Li, Di Peng, Bing Li, Zhou Zhang, Shibo Wu   +7 more
wiley   +1 more source

Prox1 Directly Interacts with LSD1 and Recruits the LSD1/NuRD Complex to Epigenetically Co-Repress CYP7A1 Transcription

PLoS ONE, 2013
Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the first and rate-limiting step in the classical pathway of bile acids synthesis in liver and is crucial for maintaining lipid homeostasis. Hepatocyte nuclear factor 4α (HNF4α) and α1-fetoprotein transcription factor (FTF) are two major transcription factors driving CYP7A1 promoter activity in hepatocytes.
Huafang Ouyang, Youhua Xie, Youhua Xie, Yanfeng Liu, Yi Qin, Jing Liu   +5 more
openaire   +5 more sources

Defective heart development in hypomorphic LSD1 mice [PDF]

Cell Research, 2011
Lysine-specific demethylase 1 (LSD1/AOF2/KDM1A), the first enzyme with specific lysine demethylase activity to be described, demethylates histone and non-histone proteins and is essential for mouse embryogenesis. LSD1 interacts with numerous proteins through several different domains, most notably the tower domain, an extended helical structure that ...
En Li, Reginald Valdez, Jing Wang, Thomas B. Nicholson, Sarah Hevi, Mark Labow, Jeff Bajko, Hui Su, Xiaodong Cheng, Joseph Loureiro, Taiping Chen, Mei Li, Bernd Kinzel   +12 more
openaire   +3 more sources

The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression

Journal of Experimental & Clinical Cancer Research, 2022
Background Downregulation of epithelial markers and upregulation of mesenchymal markers are the characteristics of the epithelial to mesenchymal transition (EMT) program, which provides the metastatic advantage of breast cancer.
Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen, Hai Rao   +4 more
doaj   +1 more source

Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges

Cancer Science, EarlyView.
Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Gang Li, Bing Wang, Lisha Ye, Guohua Wang   +3 more
wiley   +1 more source

Epigenetic regulation affects gene amplification in Drosophila development

Frontiers in Bioscience-Landmark, 2020
In Drosophila melanogaster, in response to developmental transcription factors, and by repeated initiation of DNA replication of four chorion genes, ovarian follicle cells, form an onion skin-type structure at the replication origins. The DNA replication
Hidetsugu Kohzaki, Maki Asano, Yota Murakami, Alexander Mazo   +3 more
doaj   +1 more source

Organoids in Haematologic Research: Advances and Future Directions

Cell Proliferation, EarlyView.
This review focuses on the advancements in organoid technology and its transformative role in haematological research, particularly in the modelling of haematopoietic tissues, blood diseases and drug development. It also offers an outlook on the future prospects of organoids in personalised medicine and the study of disease mechanisms.
Liangzheng Chang, Lu Li, Yuling Han, Hui Cheng, Liuliu Yang   +4 more
wiley   +1 more source

PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory

Scientific Reports, 2017
Lysine-specific demethylase 1 (LSD1) is a histone demethylase that participates in transcriptional repression or activation. Recent studies reported that LSD1 is involved in learning and memory.
Chae-Seok Lim, Hye Jin Nam, Jaehyun Lee, Dongha Kim, Ja Eun Choi, SukJae Joshua Kang, Somi Kim, Hyopil Kim, Chuljung Kwak, Kyu-Won Shim, Siyong Kim, Hyoung-Gon Ko, Ro Un Lee, Eun-Hae Jang, Juyoun Yoo, Jaehoon Shim, Md Ariful Islam, Yong-Seok Lee, Jae-Hyung Lee, Sung Hee Baek, Bong-Kiun Kaang   +20 more
doaj   +1 more source

REIMAGINE: A central nervous system basket trial showing safety and efficacy of vafidemstat on aggression in different psychiatric disorders

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Vafidemstat is a brain‐penetrant, orally bioavailable, small molecule irreversible inhibitor of the histone lysine‐specific demethylase KDM1A (also known as LSD1), which corrects memory deficits and behavior alterations including aggression and social interaction deficits in preclinical models.
Marc Ferrer, Vanesa Richarte, Laura Gisbert, Jordi Xaus, Sonia Gutierrez, Maria Isabel Arevalo, Michael Ropacki, Roger Bullock, Carlos Buesa, Josep Antoni Ramos‐Quiroga   +9 more
wiley   +1 more source