Results 1 to 10 of about 17,765 (99)
Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing Virus
Microbiology Spectrum, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the highly contagious agent responsible for the coronavirus disease 2019 (COVID-19) pandemic.
Kevin Chiem +8 more
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Frontiers in Pharmacology, 2023 The dopamine D4 receptor (D4R) is expressed in the retina, prefrontal cortex, and autonomic nervous system and has been implicated in attention deficit hyperactivity disorder (ADHD), substance use disorders, and erectile dysfunction.
Viktor Burström +11 more
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Bioengineering, 2022 Reporter phage assays are a promising alternative to culture-based assays for rapidly detecting viable bacteria. The reporter systems used in phage-based detection are typically enzymes and their corresponding substrates that provide a signal following ...
Shalini Wijeratne +2 more
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Frontiers in Immunology, 2023 Investigations into the strength of antigen-specific responses in vitro is becoming increasingly relevant for decision making in early-phase research of novel immunotherapeutic approaches, including adoptive cell but also immune checkpoint inhibitor (ICI)
Jimena Álvarez Freile +6 more
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Reverse Genetic Approaches for the Generation of Full Length and Subgenomic Replicon of EV71 Virus
Frontiers in Microbiology, 2021 Enterovirus 71 (EV71) is a neurotropic pathogen that causes hand, foot, and mouth disease (HFMD) and it has been consistently associated with severe neurological, cardiac, and respiratory complications.
Hang Yang +5 more
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Luciferase‐free Luciferin Electrochemiluminescence
Angewandte Chemie International Edition, 2022 AbstractLuciferin is one of Nature's most widespread luminophores, and enzymes that catalyze luciferin luminescence are the basis of successful commercial “glow” assays for gene expression and metabolic ATP formation. Herein we report an electrochemical method to promote firefly's luciferin luminescence in the absence of its natural biocatalyst ...
Mattia Belotti +7 more
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Luciferase Controlled Protein Interactions
Journal of the American Chemical Society, 2021 Protein trafficking and protein-protein interactions (PPI) are central to regulatory processes in cells. Induced dimerization systems have been developed to control PPI and regulate protein trafficking (localization) or interactions. Chemically induced dimerization (CID) has proven to be a robust approach to control protein interactions and ...
Dalu Chang +4 more
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Using Biosensors to Study Protein–Protein Interaction in the Hippo Pathway
Frontiers in Cell and Developmental Biology, 2021 The Hippo signaling network is dependent on protein–protein interactions (PPIs) as a mechanism of signal transduction to regulate organ size, cellular proliferation and differentiation, tumorigenesis, and other cellular processes.
Alexander Pipchuk, Xiaolong Yang
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Pharmaceuticals, 2021 Bioactive plant compounds and extracts are of special interest for the development of pharmaceuticals. Here, we describe the screening of more than 1100 aqueous plant extracts and synthetic reference compounds for their ability to stimulate or inhibit ...
Roland Hager +10 more
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Frontiers in Cellular and Infection Microbiology, 2022 Malaria elimination is dependent on the ability to target both the pathogenic and transmissible stages of the human malaria parasite, Plasmodium falciparum.
Janette Reader +3 more
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